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Topic: Treatment for HER-2 + after being treated for Her-2 negative

Forum: Mixed Type Breast Cancer — Meet others who have mixed type breast cancer.

Posted on: Feb 12, 2020 09:28AM - edited Feb 12, 2020 09:32AM by bkerber

bkerber wrote:

I had 2 tumors removed in November. The largest was ER + PR - Her-2 neg. The smaller tumor was PR + and Her2 equivocal.
After much analysis the smaller tumer was determined to have enough Her2 + to be treated for such. I am half way through TC chemo treatments, so now they will add Herceptin to the mix for the final 2 and then Herceptin alone for a year.

My question, is there anyone who took TC and then Herceptin by itself ? What are the differences in the side effects? Do you have to get a neulasta shot with just herceptin. I do well with my chemo now except 2 days down after the Neulasta shot is given. I get very flu like. Therefore, Im hoping I dont have to get it.
Any input would be appreciated.

Dx 10/23/2019, DCIS/IDC, Right, 2cm, Stage IB, Grade 2, 0/5 nodes, ER+/PR-, HER2- (FISH) Dx 11/18/2019, IDC, Right, <1cm, Stage IB, Grade 1, 0/5 nodes, ER+/PR+, HER2+ (FISH) Surgery 11/27/2019 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 1/14/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 2/24/2020 Herceptin (trastuzumab) Radiation Therapy 4/9/2020 Whole-breast: Breast
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Feb 12, 2020 11:17AM hapa wrote:

You have very few side effects with just herceptin. All Her2+ folks get just herceptin after finishing chemo + herceptin. You will not get or need neulasta shots, as your neutrophils are not suppressed by herceptin. After chemo, infusions of just herceptin will be a walk in the park. If you do feel like you're still having side effects, have them slow the herceptin infusion to 90 minutes (they usually like to give it in 30 minutes).

Dx 3/20/2018, IDC, Right, 3cm, Stage IIIA, 3/18 nodes, ER+/PR+, HER2+ (FISH) Targeted Therapy 3/28/2018 Herceptin (trastuzumab) Targeted Therapy 3/28/2018 Perjeta (pertuzumab) Chemotherapy 3/28/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/22/2018 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 10/22/2018 Whole-breast: Lymph nodes, Chest wall Hormonal Therapy 12/21/2018 Arimidex (anastrozole), Zoladex (goserelin) Targeted Therapy Nerlynx
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Feb 12, 2020 11:35AM Ingerp wrote:

Herceptin only SEs are relatively mild, but keep in mind they aren't nothing (at least not for me). I really pushed protein through chemo, and then cut back significantly when I was getting only H. I realized I felt a little funny after treatment--almost a little drunk. I started making a point of eating red meat the two nights before treatment days and that made a big difference. I'd recommend keeping up your protein intake.

Dx 3/11/2016, DCIS, Left, 6cm+, Stage 0, Grade 3, ER-/PR- Surgery 3/23/2016 Lumpectomy Surgery 4/20/2016 Lumpectomy: Left Radiation Therapy 5/18/2016 Whole-breast: Breast Dx 3/2/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2+ (FISH) Surgery 3/13/2018 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 5/18/2018 Taxol (paclitaxel) Targeted Therapy 5/18/2018 Herceptin (trastuzumab) Radiation Therapy 8/20/2018 Whole-breast: Breast
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Feb 12, 2020 11:52AM bkerber wrote:

Thank you ladies. I do very well with my chemo now other than Neulasta, so hopefully I will cruise through it. I will start my first herceptin with my next TC round since it was just approved by ins. I think the first infusion is 90 min and then 30 after. I will for sure ask them to extend it if I feel bad.

How about fatigue. Im still working and only take off the day of treatment and my 4th day. Im hoping to keep up that same schedule.

Dx 10/23/2019, DCIS/IDC, Right, 2cm, Stage IB, Grade 2, 0/5 nodes, ER+/PR-, HER2- (FISH) Dx 11/18/2019, IDC, Right, <1cm, Stage IB, Grade 1, 0/5 nodes, ER+/PR+, HER2+ (FISH) Surgery 11/27/2019 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 1/14/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 2/24/2020 Herceptin (trastuzumab) Radiation Therapy 4/9/2020 Whole-breast: Breast
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Feb 12, 2020 01:06PM MinusTwo wrote:

bkerber - I strongly recommend that you don't allow the Herceptin infusion for less than an hour puch time. It made a big difference to me.

Also Herceptin can have some heart issues, although they are usually temporary & resolve after the drug is finished. It would be good to have a baseline 'echo' before you start.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Feb 12, 2020 01:25PM bkerber wrote:

Thanks Minus two. I will suggest that. I had an echo already and I think they will do one on occasion. My heart dr is in the same group as them so I will be followed closely with that.

Dx 10/23/2019, DCIS/IDC, Right, 2cm, Stage IB, Grade 2, 0/5 nodes, ER+/PR-, HER2- (FISH) Dx 11/18/2019, IDC, Right, <1cm, Stage IB, Grade 1, 0/5 nodes, ER+/PR+, HER2+ (FISH) Surgery 11/27/2019 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 1/14/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 2/24/2020 Herceptin (trastuzumab) Radiation Therapy 4/9/2020 Whole-breast: Breast
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Feb 13, 2020 02:07AM WC3 wrote:

bkerber:

I had both Herceptin and Perjeta simultaneously so it's difficult to know for certain which caused it, but my only major side effect was a runny nose.

Pathologic complete response (pCR) to chemotherapy. Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 6/1/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/15/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant

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