Aug 27, 2020 05:00AM moth wrote:
" if my tumor was not responsive to AC chemo, why would it be to another kind (Taxol)? "
So, one thing to understand is that all these drugs have different mechanisms of action. Adriamycin interferes with DNA transcription, cyclophosphomide essentially forces DNA to fold in on itself and leads to cell death. Taxol targets tubulins which form when a cell is about to divide and it prevents cell mitosis. The whole point of using various chemos is because they act on different phases and processes of cell division. So just because something did not respond to one, doesn't mean it won't respond to a different type. Did you have Oncotype done?
If you are uncomfortable with your care team, you could consider a second opinion. I believe we have to really have a good rapport and trust in our oncology teams. just fyi, there is no documented overall survival benefit to lumpectomy + rads over mastectomy so while it's often our natural inclination to just want to get it all out, there are reasons doctors sometimes recommend lumpectomy. It's a much smaller & less risky surgery with much faster recovery. "Lumpectomy followed by radiation is likely to be equally as effective as mastectomy for people with only one site of cancer in the breast and a tumor under 4 centimeters." https://www.breastcancer.org/treatment/surgery/mast_vs_lump
Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the OddsDx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone