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All TopicsForum: Less Common Types of Breast Cancer → Topic: Mucinous Carcinoma of the breast

Topic: Mucinous Carcinoma of the breast

Forum: Less Common Types of Breast Cancer — Meet others with less common forms of breast cancer, such as Medullary carcinoma, Inflammatory breast cancers, Mucinous carcinoma (colloid carcinoma), Paget's disease, Papillary carcinoma, Phyllodes tumor, Tubular carcinomas, Metaplastic tumors, Adenoid cystic carcinomas and Angiosarcoma.

Posted on: Apr 23, 2009 05:43PM

peggym wrote:

On April 21st I had a core biopsy and today I was told that I have mucinous carcinoma of the breast.  When I investigated on this website, the information given was that this is a rare type of cancer, about 2-3% of all breast cancers and usually occurs in post-menopausal women over the age of 60.  I am neither.  I am 51 years old, but still menstruate.  I have an appointment with a surgeon, but feel as though I am in the state of shock.  This "nodule" was found on routine mammogram and I convinced myself that it was nothing.

This may sound odd at my age, but I just recently started to enjoy and like 'these babies'.  The thought of losing my breast scares me tremendously, and I have not even considered the thought of this cancer metastasizing.  I won't think of that!

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Jun 12, 2013 06:52AM voraciousreader wrote:

mumo....you can request that your case be reviewed by a tumor board....or you may wish to have a second or third opinion.  But remember, with a low Oncotype DX score, it usually means that the risks of chemo outweigh the benefits.  Furthermore, there was a recent Japanese study that mentioned that patients who had mucinous breast cancer and received neoadjuvant chemotherapy, that is, chemotherapy BEFORE surgery...did NOT see their tumors significantly shrink.  However, following surgery, they did especially well.  So it appeared from the study that with a low grade mucinous tumor, chemotherapy didn't give much of a bang for the buck as it did for the more traditional types of breast cancer.  If you had a low Oncotype DX score, you probably would benefit more from endocrine therapy.  Furthermore...with a large tumor like yours, the fact that you were node negative is an indication that you have a non-aggressive tumor.  Usually, patients who have large tumors have node involvement.  Regarding the radiation, most patients do well.  There was a recent study that patients who did lumpectomies with radiation did slightly better than those patients who did just mastectomies.  If your physician is recommending radiation, ask them to explain the reasoning behind it.  Also ask for recent studies as well.  I think the doctor is recommending it in your case because you had a large tumor.  Keep us posted.  Good luck!  Congrats on the low Oncotype DX score!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jun 12, 2013 07:03AM Mandksmum wrote:

That's the result I'm actually hoping for, no chemo but rads. My tumor was 44mm, no nodes on ultra sounds but obviously that's only 80% correct so need to wait the 3 weeks to find out.

32 at DX was told I was too young, no family history and not to worry, how wrong could they of been! Dx 5/16/2013, 4cm, Grade 2, 0/4 nodes, ER+, HER2- Surgery 06/09/2013 Lumpectomy in one or both breasts: Lumpectomy in my left breast; Reconstruction of my left breast
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Jun 12, 2013 07:28AM mumofone wrote:

Thank you both :)

voraciousreader, I appreciate the information, and I wonder if my medical team are now taking the fact that this is a mucinous tumour into account, together with the low oncotype dx score. The Japanese study you mentioned is very encouraging and puts my mind at rest somewhat... it was always my fear that I would go through chemo for very little benefit and a huge bucketful of risk... I'm so grateful I found this forum and discovered more about mucinous tumours. My concern is the radiotherapy now, which I will do if it's recommended, but I would like to know the reason why.

Mandksmum, we sound as though we have similar situations. I was horrified to find out my lump was so large, but when I found out it was mucinous it made more sense that there were no nodes involved. I have everything crossed that you get the results you are hoping for. I asked for a copy of my pathology report, which I found very useful. Will you be getting the oncotype dx test done? I was told it will be available on the NHS at the end of the summer, a little too late for us unfortunately. Please let us know how you're getting on.

Dx: Mar 2013 / Lumpectomy+Mastectomy: Grade 1 IDC (mucinous) & DCIS, 4.1cm, ER+/PR+ HER2-, 0/3 nodes
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Jun 12, 2013 07:38AM Golden01 wrote:

Congratulations on the great news, Mumofone! Waiting can make us numb. It is hard, you used the word unbearable and I think you described it well. I watched a lot of  mindless television while I was waiting and during my recovery from surgeries - all 39 episodes of Arrested Development and every season of Sex and the City! 

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2-
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Jun 12, 2013 08:31AM Mandksmum wrote:

Mumofone is that the £2.5k test? Probs not no. Bad enough I'm off work, self employed having to pay full time staff to run my shop.

32 at DX was told I was too young, no family history and not to worry, how wrong could they of been! Dx 5/16/2013, 4cm, Grade 2, 0/4 nodes, ER+, HER2- Surgery 06/09/2013 Lumpectomy in one or both breasts: Lumpectomy in my left breast; Reconstruction of my left breast
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Jun 12, 2013 08:48AM , edited Jun 12, 2013 10:22AM by mumofone

Thanks Golden01, it's beginning to sink in now :)

Mandksmum, it is expensive unfortunately... we were told around £2k (haven't had the bill yet). We decided to do it when the oncologist started recommending chemo. 

Dx: Mar 2013 / Lumpectomy+Mastectomy: Grade 1 IDC (mucinous) & DCIS, 4.1cm, ER+/PR+ HER2-, 0/3 nodes
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Jun 14, 2013 08:39AM , edited Jun 14, 2013 08:54AM by katiekabooom

<<there was a recent Japanese study that mentioned that patients who had mucinous breast cancer and received neoadjuvant chemotherapy, that is, chemotherapy BEFORE surgery...did NOT see their tumors significantly shrink.  However, following surgery, they did especially well >>

VR, what do you mean by "especially well"?  My understanding of MC is that it has a very low likelihood of metastizing, so with a low oncotype dx score, what would be the upside of doing chemo following surgery?

Also, is there a link to the japanese study? i need to start reading up as my surgeon as recommended me for chemo post bilateral mastectomy (which I had after having 2 lumpectomies, radiation and a oncotype dx of 11).  I am not at all convinced that chemo is the right next step esp since i am pre-menopausal and on tamoxifen

dx 1: 6/23/11 and re dx:2 4/23/13 -- Mucinous Carcinoma. Double Mastectomy May 28, TC Chemo starting July 25. Oncotype DX 11 Dx 6/23/2011, 2cm, Stage IIB, Grade 2, 0/3 nodes, ER+/PR+, HER2-
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Jun 14, 2013 12:31PM voraciousreader wrote:

Breast. 2012 Jun;21(3):289-95. doi: 10.1016/j.breast.2011.12.011. Epub  2012 Jan 25.

The differences in the histological types of breast cancer and the response to neoadjuvant chemotherapy: the relationship between the outcome and the clinicopathological characteristics.

Source

Department of Breast Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Abstract

Although effective regimens have been established for invasive ductal carcinoma-not otherwise specified (IDC), the efficacy and prognosis of other minor types of breast cancer are unknown because of their rareness. The clinicopathological features and prognosis of other minor types concerning the response to neoadjuvant chemotherapy (NAC) were evaluated in this study. A total of 562 patients were classified according to the Japanese and the World Health Organization (WHO) classifications, and the number of IDC and other special types (SP) was 500 and 62. The SP patients had a significantly poorer clinicopathological response to NAC and less breast-conservative therapy than those with IDC. According to the WHO classification, mucinous carcinoma, metaplastic carcinomas and apocrine carcinoma also responded poorly, and patients with metaplastic carcinomas and invasive lobular carcinoma had a significantly poorer prognosis. Despite the poor response to chemotherapy, patients with mucinous carcinoma and apocrine carcinoma had a good prognosis. The response to NAC and the prognosis vary for each histological type. For some types, the prognosis was not related to the clinicopathological response to NAC.

BACKGROUND:

In the treatment of breast cancer, neoadjuvant chemotherapy (NAC) has become the standard treatment modality for downstaging purposes. Although effective regimens have been established for the treatment of invasive ductal carcinoma-not otherwise specified (IDC), the data about the efficacy and prognosis for patients with other minor types of breast cancer are insufficient because of the rareness of these tumors. Defining the relationship between each histological type and the clinicopathological response to NAC is essential to optimizing individualized treatment.

METHODS:

We retrospectively evaluated the clinicopathological features and classification of the histological types based on the Japanese and the World Health Organization (WHO) classifications before and after NAC in 562 patients with primary breast cancer who underwent curative treatment after NAC between 1998 and 2008. The prognosis was estimated for each histological type.

RESULTS:

Of the 562 patients, the number of cases of IDC and other special types (SP) was 500 and 62. In the SP group, the clinicopathological response to NAC was significantly poorer, and the patients underwent breast-conservative therapy less frequently than did the IDC patients. According to the WHO classification, mucinous carcinoma, metaplastic carcinomas and apocrine carcinoma responded poorly to NAC. The disease-free survival and overall survival were significantly worse for patients with metaplastic carcinomas (p<0.001 and p<0.001) and with invasive lobular carcinoma (p=0.03 and p<0.001) than other cancers. Despite their poor response to treatment, patients with mucinous carcinoma and apocrine carcinoma had a good prognosis.

CONCLUSIONS:

The response to standardized NAC and prognosis varies for each histological type. For some types, the prognosis was not associated with the clinicopathological response to NAC. Innovative regimens should therefore be investigated for each histological type to achieve the best response.

Copyright © 2011 Elsevier Ltd. All rights reserved.

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jun 15, 2013 06:41AM mumofone wrote:

I just found out my actual oncotype dx score - it is 18. I would have been more comfortable with a lower score (sigh) but my oncologist has written to say she is not recommending chemo on the basis of this score.

She does suggest that radiotherapy is necessary though, which has totally confused me. I've had a mastectomy and the margins were >10mm on all sides. No node involvement. Some LVI ('evidence of') which was removed during the initial lumpectomy. My mind is churning over again now. I have an appointment to see the oncologist on Wednesday, to discuss this, although the letter says I've already been booked in for the radiotherapy sessions! Does anyone else have experience of this?

Dx: Mar 2013 / Lumpectomy+Mastectomy: Grade 1 IDC (mucinous) & DCIS, 4.1cm, ER+/PR+ HER2-, 0/3 nodes
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Jun 18, 2013 05:09AM , edited Jun 18, 2013 05:12AM by EnELLE

This Post was deleted by EnELLE.
Pure Mucinous Carcinoma, KI-67 8%, ER 100%, PR 100% Dx 12/14/2012, 3cm, Stage IIA, Grade 1, 0/4 nodes, ER+/PR+, HER2- Dx 3/13/2014, Grade 1, 2/10 nodes, ER+/PR+, HER2- Surgery 05/11/2014 Lymph node removal (also called dissection): Underarm (axillary) lymph node removal (also called dissection) , Lymph node removal (also called dissection) on my left side Surgery 01/29/2013 Mastectomy of one or both breasts: Mastectomy of my left breast; Lymph node removal (also called dissection): Lymph node removal (also called dissection) on my left side ; Reconstruction of my left breast: Tissue expander placement
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Jun 18, 2013 02:02PM FeelingtheMagic wrote:

Celebrating... finished my last herceptin treatment. No more chemo, no more herceptin! Whoot whoot! Now, if I can just get this tamoxifen behaving better. ~smile~

Reading through your posts, thinking of all of you on this chaotic experience. Besides the research, the decisions and the 'must do's' to heal, I hope you're also getting to do things that lift your spirits. (Art, writing, paddleboarding, camping, grandkids are my things. Lately I work harder at getting spirits lifted, currently on supplement regime to improve moods and kick hair growth back in gear!)   Warm thoughts and prayers to all of you.

DCIS and Pure mucinous and Her2+ WTF? (oops did I say that?) Dx 3/2/2012, 1cm, Stage I, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Targeted Therapy 06/24/2012 Herceptin (chemical name: trastuzumab) Surgery 04/03/2012 Lumpectomy in one or both breasts: Lumpectomy in my left breast Surgery 05/01/2012 Mastectomy of one or both breasts: Mastectomy of my left breast Surgery 03/04/2013 Reconstruction of my left breast Chemotherapy 06/24/2012 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Jun 18, 2013 04:47PM voraciousreader wrote:

Feeling... Congrats on finishing active treatment... I wish you well... Really, really well!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jun 18, 2013 05:18PM FeelingtheMagic wrote:

Thank you, Voracious. ~smile~

DCIS and Pure mucinous and Her2+ WTF? (oops did I say that?) Dx 3/2/2012, 1cm, Stage I, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Targeted Therapy 06/24/2012 Herceptin (chemical name: trastuzumab) Surgery 04/03/2012 Lumpectomy in one or both breasts: Lumpectomy in my left breast Surgery 05/01/2012 Mastectomy of one or both breasts: Mastectomy of my left breast Surgery 03/04/2013 Reconstruction of my left breast Chemotherapy 06/24/2012 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Jun 24, 2013 12:14AM Mandksmum wrote:

Well it's been 2 weeks post op and still another week tomorrow to wait for results, the waiting is just the worst not knowing if I need more surgery or if I will be able to start next step.

32 at DX was told I was too young, no family history and not to worry, how wrong could they of been! Dx 5/16/2013, 4cm, Grade 2, 0/4 nodes, ER+, HER2- Surgery 06/09/2013 Lumpectomy in one or both breasts: Lumpectomy in my left breast; Reconstruction of my left breast
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Jun 24, 2013 11:28AM mumofone wrote:

Mandksmum, I found waiting extremely tedious and frustrating... but it will all happen in good time :). Fingers crossed you will get the results you are hoping for.

FeelingtheMagic, congrats from me too! And thank you for reminding us to do uplifting things at these difficult times. It isn't always easy but is important to make the effort. I've found myself writing more, and now I have a craving to paint! Even tiny things (like a walk) can help.

Dx: Mar 2013 / Lumpectomy+Mastectomy: Grade 1 IDC (mucinous) & DCIS, 4.1cm, ER+/PR+ HER2-, 0/3 nodes
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Jun 24, 2013 02:03PM FeelingtheMagic wrote:

Mumofone,I'm a life coach and a creativity coach... I've really had to call on that for me. All I can say is small steps, teeny tiny steps are the best best way to 'move along' whether it's getting active, eating better, creating... but especially whatever lifts our spirits... because that will help all the other areas.. Yay you for writing and hope you get to paint. (ps. 'small and crappy' is a good philosophy to start anything creative, it tricks the fears around all the myths about what our creativity is supposed to be and lets us enjoy it)

DCIS and Pure mucinous and Her2+ WTF? (oops did I say that?) Dx 3/2/2012, 1cm, Stage I, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Targeted Therapy 06/24/2012 Herceptin (chemical name: trastuzumab) Surgery 04/03/2012 Lumpectomy in one or both breasts: Lumpectomy in my left breast Surgery 05/01/2012 Mastectomy of one or both breasts: Mastectomy of my left breast Surgery 03/04/2013 Reconstruction of my left breast Chemotherapy 06/24/2012 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Jun 28, 2013 06:49PM cdicapua wrote:

You are not alone I had mucinous carcinoma and dcis

Cathy DiCapua Dx 9/4/2011, DCIS, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-
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Jun 30, 2013 05:48AM AustJourney wrote:

Hi Everyone

This week I'm back to work after 7 months - 9 weeks chemo and remainder of time surgery related. I'm not yet finished herceptin - halfway through, but all good so far. My surgery to replace expander is done and has gone very smoothly - I'm pleased with the results.

My oncologist has been very positive about future prognosis.

My hair is well and truly growing back and is now getting a little wave. I'm feeling stronger with each day.

I had some slight bumps with tamoxifen - anxiety, stomach upset and headache. Mild hot flashes at night. Mostly settled now - 5 weeks in.

Wishing everyone well with their treatment - it does get better.

Dx 11/30/2012, IDC, <1cm, Stage I, Grade 3, 0/2 nodes, ER+/PR-, HER2+ Targeted Therapy 01/14/2013 Herceptin (chemical name: trastuzumab) Surgery 12/14/2012 Mastectomy of one or both breasts: Mastectomy of my left breast Chemotherapy 01/14/2013 Taxol (chemical name: paclitaxel)
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Jun 30, 2013 05:55AM voraciousreader wrote:

Aust... Congrats on almost completing active treatment! Glad to hear you are doing well!!! Thoughts and prayers to you and all our sisters on this journey!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jun 30, 2013 10:37PM , edited Jun 30, 2013 10:38PM by tricianneAust

Hi AustJourney, More Congrats. It is most encouraging to see how your progress is going. If it is any assistance my friends who have also had breast cancer and I all had minimal to no side effects within 12 weeks. This was the prediction too of the oncologist and breast cancer specialist as well. While side effects decrease to some extent earlier it is great when they disappear, especially the anxiety it is such a nuisance as it is often not at all logical. Lots of prayers for all you of you whatever stage you are on. Many blessings Tricianne.

TricianneAust Dx: 10/20/2010, DCIS Pure Mucinous Cancer , 2cm, Stage I, Grade 1, 0/3 nodes, ER+75% /PR+ 75%, HER2-. Lumpectomy,Tamoxifen,25 x radiation, Vit D deficiency being treated. Nov 2014 Mammogram all fine. Well & healthy!
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Jun 30, 2013 11:46PM FeelingtheMagic wrote:

Congrats Austjourney!  Glad to hear you're settling into Tamoxifen well and able to get back to work.

I'm still waiting.. re the tamoxifen settling... now at six months... (smile) .. .thought I was settled in, but quirky things going on. .hair all stopped growing, burning skin, anxious, somewhat depressed, joint pain.. bla bla bla.  Currently on a regime of supplements to kick that crankiness and other symptoms, which are considered to be related to my metachondria unhappy (our healthy fast growing daily cells.. in layman's terms. Ie: my terms) The supplements are helping tremendously. (recommended by my integrative cancer care doctor.. so all above board, nothing that messes with treatments)
Keep well, dear women!

DCIS and Pure mucinous and Her2+ WTF? (oops did I say that?) Dx 3/2/2012, 1cm, Stage I, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Targeted Therapy 06/24/2012 Herceptin (chemical name: trastuzumab) Surgery 04/03/2012 Lumpectomy in one or both breasts: Lumpectomy in my left breast Surgery 05/01/2012 Mastectomy of one or both breasts: Mastectomy of my left breast Surgery 03/04/2013 Reconstruction of my left breast Chemotherapy 06/24/2012 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Jul 1, 2013 03:22PM Crystal_ wrote:

Hello Everyone,

I am 44. I was diagnosed with a mucinous carcinoma (5cm) June 10.  I am still putting together all the information from the path report and don’t completely have all the pieces filled in yet.  I’ve tried to do as much research as I can, but I know each person’s case is different and I don’t have all the specifics about my tumor.  I saw a surgeon last week.  He recommended 3 months of chemo before surgery to see if we can shrink the tumor prior to surgery (to avoid major reconstruction).  I see an oncologist next week to discuss her definition of “chemo.” I am naively hoping that it will be just Tamoxifen, but I have a feeling due to the size, that I may end up having a harsher regimen as well.  I guess my biggest concern and worry (which no one can really answer) is potential lymph node involvement.   I had an MRI with contrast. The surgeon did not seem concerned about lymph nodes, but said that he would biopsy my nodes during surgery (in three months).  I know that this type of cancer has a lower rate of metastasis, but I have also read that those statistics are for tumors smaller than 5cm.  This site has been so helpful already. I am so glad to have found it. I would really appreciate any input as far as questions I should ask my oncologist next week.  I am going to talk to her of course about treatment and the lymph node concern, but don’t know if there is anything I should be sure to ask about as well. I consider myself to be informed and on top of things...but sure dont feel like it in this arena. Thank you for any input.

Mucinous carcinoma. Dx 6/10/2013, 5cm, Stage IIB, ER+/PR+, HER2-
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Jul 1, 2013 05:32PM voraciousreader wrote:

Crystal....Sorry to hear about your diagnosis.  When you meet with your oncologist next week, please show them this study:



Breast. 2012 Jun;21(3):289-95. doi: 10.1016/j.breast.2011.12.011. Epub  2012 Jan 25.

The differences in the histological types of breast cancer and the response to neoadjuvant chemotherapy: the relationship between the outcome and the clinicopathological characteristics.

Source

Department of Breast Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Abstract

Although effective regimens have been established for invasive ductal carcinoma-not otherwise specified (IDC), the efficacy and prognosis of other minor types of breast cancer are unknown because of their rareness. The clinicopathological features and prognosis of other minor types concerning the response to neoadjuvant chemotherapy (NAC) were evaluated in this study. A total of 562 patients were classified according to the Japanese and the World Health Organization (WHO) classifications, and the number of IDC and other special types (SP) was 500 and 62. The SP patients had a significantly poorer clinicopathological response to NAC and less breast-conservative therapy than those with IDC. According to the WHO classification, mucinous carcinoma, metaplastic carcinomas and apocrine carcinoma also responded poorly, and patients with metaplastic carcinomas and invasive lobular carcinoma had a significantly poorer prognosis. Despite the poor response to chemotherapy, patients with mucinous carcinoma and apocrine carcinoma had a good prognosis. The response to NAC and the prognosis vary for each histological type. For some types, the prognosis was not related to the clinicopathological response to NAC.

BACKGROUND:

In the treatment of breast cancer, neoadjuvant chemotherapy (NAC) has become the standard treatment modality for downstaging purposes. Although effective regimens have been established for the treatment of invasive ductal carcinoma-not otherwise specified (IDC), the data about the efficacy and prognosis for patients with other minor types of breast cancer are insufficient because of the rareness of these tumors. Defining the relationship between each histological type and the clinicopathological response to NAC is essential to optimizing individualized treatment.

METHODS:

We retrospectively evaluated the clinicopathological features and classification of the histological types based on the Japanese and the World Health Organization (WHO) classifications before and after NAC in 562 patients with primary breast cancer who underwent curative treatment after NAC between 1998 and 2008. The prognosis was estimated for each histological type.

RESULTS:

Of the 562 patients, the number of cases of IDC and other special types (SP) was 500 and 62. In the SP group, the clinicopathological response to NAC was significantly poorer, and the patients underwent breast-conservative therapy less frequently than did the IDC patients. According to the WHO classification, mucinous carcinoma, metaplastic carcinomas and apocrine carcinoma responded poorly to NAC. The disease-free survival and overall survival were significantly worse for patients with metaplastic carcinomas (p<0.001 and p<0.001) and with invasive lobular carcinoma (p=0.03 and p<0.001) than other cancers. Despite their poor response to treatment, patients with mucinous carcinoma and apocrine carcinoma had a good prognosis.

CONCLUSIONS:

The response to standardized NAC and prognosis varies for each histological type. For some types, the prognosis was not associated with the clinicopathological response to NAC. Innovative regimens should therefore be investigated for each histological type to achieve the best response..



___________________________________________________________________________________



Also find out if your tumor is ER + and whether or not you are HER2 negative.  You have a lot of decisions to make.  On one hand, your tumor is large and if you want to avoid a mastectomy, having neoadjuvant treatment to try to shrink the tumor is worth considering.  Likewise, if you do decide NOT to have neoadjuvant treatment and decide instead to have a lumpectomy or mastectomy....you would be a candidate for the OncotypeDX genetic test to see if you would benefit from chemotherapy....that is if you are ER postive and HER2 negative.

While the NCCN guidelines recommends adjuvant endocrine therapy for mucinous tumors larger than 3 cm, unless you are node positive, the NCCN guidelines do NOT explicitly recommend chemotherapy.  Please register at the NCCN website and look at the professional/physician version, page 20, and read about the guidelines that are specific to mucinous and tubular breast cancer. 



Good luck.  Thoughts and prayers to you!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jul 3, 2013 04:27AM Mandksmum wrote:

Got my op results yesterday, pure mucinous 44mm, grade 1, no nodes, clear margins, no chemo. Start rads in 4 weeks followed by 5 years of tamoxifen.

32 at DX was told I was too young, no family history and not to worry, how wrong could they of been! Dx 5/16/2013, 4cm, Grade 2, 0/4 nodes, ER+, HER2- Surgery 06/09/2013 Lumpectomy in one or both breasts: Lumpectomy in my left breast; Reconstruction of my left breast
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Jul 3, 2013 05:29AM voraciousreader wrote:

Mandksmum....Thanks for the update.  Wishing you well with the rest of your active treatment!  Glad to hear about your favorable report!!!!!  You also might wish to update your signature profile.  Looks like you were downgraded to a grade 1!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Jul 3, 2013 12:57PM Crystal_ wrote:

voraciousreader: Thank you for the information.  I hope that my oncologist is familiar with the article, but will ask for her thoughts. I am getting services at a research hospital. Reviewed my oncologist's bio, which includes breast cancer research with combinations of chemotherapy and farnesyltransferase inhibitors. To what extent any of her research will apply to me is unknown, but at least it might mean that she is exploring favorable combinations based on research. 

Mandksmum: Congratulations on your encouraging results!

Be well everyone.

Mucinous carcinoma. Dx 6/10/2013, 5cm, Stage IIB, ER+/PR+, HER2-
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Jul 5, 2013 06:19AM tricianneAust wrote:

Hi Mandksmum after your long wait and all the worry that goes with it your results are most encouraging. Blessings on your future treatment.

Hi Crystal R lots of prayers for you as you tackle the next stage of this journey. I too hope that your oncologist is conversant with the article, at least she has an inquiring mind.

Hi Feelingthemagic may those lousy cranky side effects of Tamoxifen fade away quickly, isn't it incredible what hormones do to us. Lots of best wishes as your treatment proceeds.

Hi Voraciousreader, thanks as usual for all your interesting input that helps us all to think it through with current information.

Lots of prayers and blessings Patricia

TricianneAust Dx: 10/20/2010, DCIS Pure Mucinous Cancer , 2cm, Stage I, Grade 1, 0/3 nodes, ER+75% /PR+ 75%, HER2-. Lumpectomy,Tamoxifen,25 x radiation, Vit D deficiency being treated. Nov 2014 Mammogram all fine. Well & healthy!
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Jul 5, 2013 01:04PM DragonladyTina wrote:

Hi everyone,

It has been quite a while since I posted on this site but thought I would check in and let you know my progress with mucinous carcinoma. I was diagnosed with a very large tumor in Dec/04, went through double mast. aggressive chemo, reconstruction, total hyst and 5 years of tamoxifen. Fast forward to today, doing well and off tamoxifen, no real problems to report. 9 yrs cancer free this december. There is hope and a light at the end of the tunnel after BC.

Tina

Live, Laugh and Love Dx 12/2/2004, 6cm+, Stage I, Grade 1, 0/19 nodes, ER+/PR+, HER2-
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Jul 5, 2013 05:16PM tricianneAust wrote:

Lovely to hear from you DragonladyTina so glad to hear that after all that treatment you are making such good progress. Long may it continue. Many blessings Tricianne

TricianneAust Dx: 10/20/2010, DCIS Pure Mucinous Cancer , 2cm, Stage I, Grade 1, 0/3 nodes, ER+75% /PR+ 75%, HER2-. Lumpectomy,Tamoxifen,25 x radiation, Vit D deficiency being treated. Nov 2014 Mammogram all fine. Well & healthy!
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Jul 5, 2013 05:43PM voraciousreader wrote:

Tina!!! Happy dance for you!!! May we all continue to celebrate one another's good health!!

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)

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