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Jan 29, 2020 02:22PM
Jan 29, 2020 02:33PM
I'm reading scientific articles that indicate that lymphovascular invasion is more of a predictor of metastasis and it has a relationship with positive sentinel node biopsy.
In a retrospective study of 256 patients by Elezoglu, increase in SLN metastasis was detected to be associated with the vascular invasion of the primary tumor, the presence of lymphatic invasion, increased primary tumor diameter, and advanced age . In a study by Ozmen et al., a tumor size larger than 2 cm (comparison of the T1 and T3 tumors) and the LVI presence were associated with SLN positivity .
It won't let me post the link to full articles
Lymphovascular invasion is a crucial step in the complex process of tumour metastasis and an important criterion for further therapy. The presence of carcinoma cells in either lymphatic vessels (lymphatic invasion), blood vessels (vascular invasion) or both (lymphovascular invasion) is a significant prognostic factor in invasive breast cancer, with respect to local and distance recurrenceand poorer survival. At the St. Gallen meeting in 2005, lymphovascular invasion was recognised as a prognostic factor for node-negative patients.[ Node-negative patients with lymphovascular invasion had higher breast cancer mortality rate (53%) compared with patients with no lymphovascular invasion (29%). Lymphovascular invasion is also associated with other strongest prognostic factors including tumour size, grade and loco- regional lymph node involvement.
My core needle aspiration pathology report states "Vascular lymphatic space invasion: Not identified"
My axillary lymph nodes are not inflammed. My mammogram and ultrasound found no suspicious indicators of lymph node involvement either.
I checked all mucinous IDC sister's signatures on this thread and most did not have positive nodes.
All of this information makes me wonder if the sentinel node biopsy is actually absolutely necessary.
I really don't want to risk having long term serious side effects from this procedure. I supposed when the tumor is out, they will do another biopsy and at that point I can review this further and decide if I want a sentinel node biopsy at a later time?
Severe vitamin D deficiency being treated. Dx 1/17/20 IDC Mucinous type ER + 90% PR + 90% HER2 - FISH