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Topic: Pleomorphic Lobular Carcinoma Triple Negative

Forum: Less Common Types of Breast Cancer — Meet others with less common forms of breast cancer, such as Medullary carcinoma, Inflammatory breast cancers, Mucinous carcinoma (colloid carcinoma), Paget's disease, Papillary carcinoma, Phyllodes tumor, Tubular carcinomas, Metaplastic tumors, Adenoid cystic carcinomas and Angiosarcoma.

Posted on: Mar 4, 2016 05:56AM

Numb wrote:

Is there anyone out there at all who has this type of breast cancer and if so what treatment did you get ?

Dx 2/15/2016, ILC, Right, 2cm, Stage IA, Grade 1, 0/1 nodes, ER-/PR-, HER2-
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Jul 27, 2016 11:07AM Gohan1983 wrote:

Pleomorphic Lobular Carcinoma is agressive variant of ILC, which most frequent shows Luminal B-like profile. But in opposite to classic, indolent variant (which almost always is HR+ and HER2- and low Ki67; Luminal A), IPLC exhibits HER-2 overexpression or lack of ER/PR receptors, but can have androgen receptor (AR) expression. Triple negative IPLC belongs to Luminal AR (LAR) molecular subtype. It is less aggrresive form of TNBC breast cancer and often has PIK3CA mutation, so PIK3CA inhibitors (everolimus, pictilisib) and/or bicalutamide (androgen inhibitor) may be used as efficient drugs in this rare subtype.

Dx 12/15/2013, IDC, Left, 6cm+, Stage IIIB, Grade 3, 1/19 nodes, ER+/PR+, HER2- Hormonal Therapy 12/16/2013 Femara (letrozole) Surgery 7/27/2014 Lymph node removal: Left; Mastectomy: Left Chemotherapy 9/30/2014 Taxol (paclitaxel) Hormonal Therapy 1/28/2015 Femara (letrozole) Radiation Therapy 2/5/2015 Whole-breast: Lymph nodes, Chest wall
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Sep 17, 2016 07:57PM - edited Oct 10, 2016 09:51PM by fleur-de-lis

This Post was deleted by fleur-de-lis.
High Risk due to family history, BRCA1+2 neg., P53 and PTEN neg., Phyllodes Tumor 2009, ALH 2010, Hemioanginonoma 2016, Second Phyllodes Tumor with ILC 2016.
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Feb 14, 2018 06:16PM Ginagia1 wrote:

I do. It was discovered at mastectomy as a primary. I was diagnosed with ductal carcinoma with a small percentage of e+ DCIS.

I just started Xeloda today as a preventative course for one year.

I’ve been reading about this type, and it scares me more than the ductal cancer. There is so much to learn

Dx 2/2017, DCIS/ILC/IDC, Left, 6cm+, Stage IIIC, Grade 3, 6/12 nodes, ER-/PR-, HER2- (FISH) Chemotherapy 3/1/2017 AC + T (Taxol) Chemotherapy 2/13/2018 Xeloda (capecitabine) Radiation Therapy Whole-breast: Breast, Lymph nodes
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Feb 15, 2018 02:54PM lightseeker wrote:

Hi Gina,

I'm in this group, too. I often come and read Gohans post - I hope it's true.

It gives me comfort.

I'm going to MSK next week to see Dr. Traina, a TN specialist. My oncologist has only treated one other lobular TN. She is doing well, many years out. She only underwent standard ACT chemo. She was AR+.

If I learn anything, I'll post.

xox

Eve

This is some godless, fucking bullshit. PILC TN Chemo: AC, Taxol x12,Carbo x4 , then Rads and Xeloda Dx 6/2017, ILC, Right, 2cm, Stage IIA, Grade 3, 0/24 nodes, ER-/PR-, HER2-
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Feb 26, 2018 04:22PM Ginagia1 wrote:

Wow! We are such special, unique people!

Arghh. This subtype scares me.

Dx 2/2017, DCIS/ILC/IDC, Left, 6cm+, Stage IIIC, Grade 3, 6/12 nodes, ER-/PR-, HER2- (FISH) Chemotherapy 3/1/2017 AC + T (Taxol) Chemotherapy 2/13/2018 Xeloda (capecitabine) Radiation Therapy Whole-breast: Breast, Lymph nodes
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Jun 28, 2019 08:01PM lightseeker wrote:

Thought I'd add to this. I was dx with PILC TNBC and was NOT luminal/androgen. I was shown to be basal like, so PilcTN is not always lumonal type.

This is some godless, fucking bullshit. PILC TN Chemo: AC, Taxol x12,Carbo x4 , then Rads and Xeloda Dx 6/2017, ILC, Right, 2cm, Stage IIA, Grade 3, 0/24 nodes, ER-/PR-, HER2-

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