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Topic: Who are only PR positive, ER-/ PR+/HER2- ???

Forum: Less Common Types of Breast Cancer — Meet others with less common forms of breast cancer, such as Medullary carcinoma, Inflammatory breast cancers, Mucinous carcinoma (colloid carcinoma), Paget's disease, Papillary carcinoma, Phyllodes tumor, Tubular carcinomas, Metaplastic tumors, Adenoid cystic carcinomas and Angiosarcoma.

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Posted on: Oct 28, 2019 07:10PM

Cutie wrote:

Hi All,

I am ER-, PR+ and HER2-. I have done the treatment and now need to move on. I want to collect stories such as survivor s, how treatment was done, how you manage to keep going after treatment etc.

I hope to see you all to fill in for this particular type of BC.

Cutie

Dx 12/28/2018, IDC, Right, 3cm, Stage IIIA, Grade 3, ER-/PR+, HER2+
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Nov 29, 2019 09:25AM melmcbee wrote:

Hello. My primary and bone mets ar ER positive but I just found out my ILC metastasized to the colon and it is ER neg and mildly PR positive. My her2 status is indeterminate and Im waiting on a fish test for that. I had a pet scan that also showed new bone mets so Im not sure what they are. I am shocked that it changed to ER negative. I also cant find much info on treatment for ER neg and PR pos so if you have any info I would love to hear. And I will post back what my oncologist says. Thanks

Melanie Dx 6/24/2012, ILC, 2cm, Stage IIIA, Grade 2, 8/15 nodes, ER+/PR+, HER2- Surgery 7/9/2012 Lymph node removal: Right, Sentinel; Mastectomy: Left, Right Surgery 8/9/2012 Lymph node removal: Right, Underarm/Axillary Chemotherapy 8/23/2012 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 1/9/2013 Breast, Lymph nodes Surgery 5/30/2013 Reconstruction (left); Reconstruction (right) Surgery 12/4/2013 Reconstruction (right) Dx 3/29/2017, ILC, Stage IV, metastasized to bone, ER+/PR- Dx 11/19/2019, ILC, Stage IV, metastasized to other, ER-/PR+, HER2- (IHC) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Faslodex (fulvestrant)
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Dec 5, 2019 02:27PM Cutie wrote:

I had treatment of chemo with AC and taxol total 8 dense dose plus surgery. My MO wants me to ta ko e Al drug but I still have not decided yet because it targets estrogen blocker. But I have 0 ER. Please update your treatment too. Wish you all the best and get well soon. Hope we got more people join who has ER positive only in this blog.

Cutie

Dx 12/28/2018, IDC, Right, 3cm, Stage IIIA, Grade 3, ER-/PR+, HER2+
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Dec 30, 2019 07:51AM katej128 wrote:

I am in the same boat. Hard to find people with ER-/PR+/HER2- I too wish to learn more about real stories and it seems impossible. I start TC chemo today and will then have radiation still undecided about the hormone therapy after that. Here’s hoping more people with similar diagnosies come forward. All my best to you.

Dx 10/21/2019, IDC, Left, 1cm, Stage IB, Grade 3, 0/2 nodes, ER-/PR+, HER2- (IHC) Surgery 11/19/2019 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 12/28/2019 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 4/13/2020 Whole-breast: Breast
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Dec 30, 2019 07:20PM Tmh0921 wrote:

My original tumor in 1999 was considered ER+/PR+, but ER was only 5% while PR was 95%. Many recent studies have shown that breast cancer tumors where ER receptors are less than 10% act more like ER- tumors. I was stage 1B then, and had a lumpectomy, ALND, radiation, and Tamoxifen.

My current tumor is highly ER+ (95%) and PR+ (69%), HER2-. I had BMX, chemo, and am currently on Zoladex and Tamoxifen, but will switch to an AI once they get me into menopause.

Tracy


First Dx at 27 years old in 1999, 2nd Dx 2018, 3rd Dx 2019... Current Oncotype: 26 Dx 12/7/1999, IDC, Left, 1cm, Stage IB, Grade 2, 0/14 nodes, ER+/PR+ Surgery 12/22/1999 Lumpectomy: Left; Lymph node removal: Left, Sentinel, Underarm/Axillary Radiation Therapy 1/31/2000 Whole-breast: Breast, Lymph nodes Hormonal Therapy 2/1/2000 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/24/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 9/5/2018 Lumpectomy: Left Dx 9/7/2018, DCIS, Left, <1cm, Stage 0, Grade 1 Dx 5/31/2019, IDC, Left, 3cm, Stage IIA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (IHC) Surgery 8/5/2019 Lymph node removal: Left; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Latissimus dorsi flap, Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 9/4/2019 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 12/2/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Hormonal Therapy 3/24/2020 Femara (letrozole), Zoladex (goserelin)
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Jan 2, 2020 04:11PM Cutie wrote:

Tracy,

Sorryy to hear that you had recurrence. Wonder that tamoxifen didn't help to block. I was wondering these homonal therapies block estrogen and if it works for Progesterone. I looked for data but it was limited and not exactly said. I met some doctors and some said no and some said yes. I prefer to take side effects if the primary goal benefits to treat but it is not sure. It might create hormone imbalanced.

I had chemotherapy of 4 AC and 4 Taxol, then BMX. I had complete pathology response from chemo.

Katej,

Wishing you well soon.

Wishing you all healthy, happy New year from 2020 to beyond.

Love, cutie

Dx 12/28/2018, IDC, Right, 3cm, Stage IIIA, Grade 3, ER-/PR+, HER2+
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Jan 2, 2020 04:51PM Tmh0921 wrote:

Cutie,

I agree that there isn't much data on the effectiveness of Tamoxifen on PR+ only tumors. My new tumor is considered a new primary, and what's scary is that it's HIGHLY (95%) ER+ and Tamoxifen didn't even slow it down. My oncologist doesn't think Tamoxifen is effective for me which is why I'm now doing ovarian suppression and will be switching to an AI.

Tracy

First Dx at 27 years old in 1999, 2nd Dx 2018, 3rd Dx 2019... Current Oncotype: 26 Dx 12/7/1999, IDC, Left, 1cm, Stage IB, Grade 2, 0/14 nodes, ER+/PR+ Surgery 12/22/1999 Lumpectomy: Left; Lymph node removal: Left, Sentinel, Underarm/Axillary Radiation Therapy 1/31/2000 Whole-breast: Breast, Lymph nodes Hormonal Therapy 2/1/2000 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/24/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 9/5/2018 Lumpectomy: Left Dx 9/7/2018, DCIS, Left, <1cm, Stage 0, Grade 1 Dx 5/31/2019, IDC, Left, 3cm, Stage IIA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (IHC) Surgery 8/5/2019 Lymph node removal: Left; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Latissimus dorsi flap, Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 9/4/2019 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 12/2/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Hormonal Therapy 3/24/2020 Femara (letrozole), Zoladex (goserelin)

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