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Topic: Anyone here with another primary cancer diagnosis??

Forum: Breast Cancer with Another Diagnosis or Comorbidity — Meet others who have breast cancer but also have another health diagnosis/comorbidity such as diabetes, MS, bipolar disorder, HIV or AIDS, Parkinson's Disorder, schizophrenia, etc.

Posted on: Mar 22, 2014 07:49PM

Sinsin wrote:

Anyone here with another primary cancer diagnosis?? Testing to see if I do right now. :(

I follow the Nemo Mantra, "Just keep swimming." Dx 1/14/2014, IDC, Stage IIB, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 2/12/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin) Chemotherapy 4/28/2014 Taxol (paclitaxel)
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Mar 11, 2015 07:43PM - edited Apr 25, 2015 11:04PM by JohnSmith

I assume everyone here is doing comprehensive genetic tests, not just the simple BRCA gene test. It's only logical to look for genetic mutations when you have more than two primary cancers.

These genetic companies (Color, Ambry, Invitae, Myriad, GeneDx, etc.) all offer tests that look at roughly ~20 driver genes which are associated with BC. Like BRCA, I believe all of the genes are "tumor suppressor" (DNA repair) genes. If one of these genes is mutated, errors in DNA replication add up and tumors manifest. Beyond these simple 20 gene tests, are more robust tests that look at hundreds of genes. These tests are obviously more expensive. Science has not quite caught up with the genetic discoveries to determine the clinical relevance. We are moving in that direction though. The most extreme example of gene testing is when you get your full DNA genome tested, which examines all 19,000 protein encoding genes. In the year 2000, in collaboration with worldwide institutions, the first fully decoded human genome was published on the internet. Steve Jobs, x-Apple CEO had his genome decoded for $100,000 in the year 2006, hoping to discover the mutations causing his pancreatic cancer. Today, the cost has plummeted to ~$1,000.

As more people get tested, patterns emerge that shed insight into the initiation or driver events underlying tumor cell proliferation. This generation of genomics data is also referred to as "Big Data". The NCI (National Cancer Institute), private & public institutions, and corporations are scrambling to build the computer infrastructure (databases) to handle this "Big Data". As more people get their genome sequenced, the richer the data becomes... Ultimately the patterns emerge. With these patterns, scientists can develop drugs that target the discoveries in the genome. However, this can't happen efficiently (quickly) unless the computer infrastructure is built worldwide and the silos of data that exist in each location is shared. Sharing this genomic data is CRUCIAL!! Otherwise the patterns in the "Big Data" won't emerge and no drugs will be invented. So, what does this mean for you? If you have the financial means, I'd recommend, you get your entire DNA genome sequenced. Another way to get your full genome sequenced is through clinical trials (although I haven't researched which ones yet).

Here's some of the companies offering genetic tests:
  • Color Genomics: $249 Color Kit test. Link https://getcolor.com
  • Myriad Genetics: myRisk Hereditary Cancer test. Link
  • Ambry Genetics: Makers of BreastNext. Link
  • Invitae: Women's Hereditary Cancers. Link (my wife did this one)
  • GeneDx: Comprehensive Cancer Panel. Link
Wife was Age 45 at Dx 4/2014. BMX Surgery 6/2014 revealed: ILC, Stage 2 (Multifocal ILC, largest lesion 2.2 cm), Grade 2, ER+/PR+ (95%), HER2-, Ki-67 5-10%, Oncotype 11; Variant in the ATM gene Dx 4/8/2014, ILC, Left, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery 6/26/2014 Mastectomy; Reconstruction (left); Reconstruction (right)
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Mar 31, 2015 07:22AM Sinsin wrote:

To everyone, my condolences! Hang in there!

JohnSmith, great info! Thanks so much for sharing!

I follow the Nemo Mantra, "Just keep swimming." Dx 1/14/2014, IDC, Stage IIB, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 2/12/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin) Chemotherapy 4/28/2014 Taxol (paclitaxel)
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Apr 4, 2015 04:15PM Blundin2005 wrote:

I recently watched the PBS.org program "Cancer, the Emperor of all Maladies". The program covered the historical perspective through to the present. It gave me much more insight into our disease. It was not comfortable to watch simply by the nature of the subject. However, I felt somewhat grateful that it was produced at all, grateful for the people who continue the research, and hopeful because these people exist.

I've had 3 primary cancers now. Breastcancer in 2005 (still NED)-- Bladder cancer in 2008 (still NED)-- and now lung cancer in 2013 (NED as of the 6 mo. CAT March 12). Most of my strength returned and I'm back in the garden getting the veggie boxes prepared for planting. I use my body positions when I work for intentional exercises to keep moving forward. I wish the same for all of us.

This thread is supportive to find here. BC.org is evolving too it seems. I'm glad for this. Healthy people are fortunate but can't fully fathom this journey, a fact I've come to accept. Once in awhile, we need to talk to someone who "gets it". My husband fights another devistating disease...his a rare genetic disease...I've found that I can't fully know how he must be feeling either. Our mortality is very personal no matter how great the intentions of others.

Best wishes to all as always,

Marilyn

DX 15 Aug '05, Stage1/grade1, 1.5 cm, IDC/DCIS, 0/2 nodes, ER+PR-,HER2 5%; Dx Oct 2008 bladder papilloma low grade; Dx 07/2013 Stage 2b; t3 M0, 2.0 cm lung cancer, rt. upper lobe
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Apr 6, 2015 01:44AM Rdrunner wrote:

I got the last episode of that program and would have loved to have seen it all.


Dx 10/23/2012, ILC, 6cm+, Stage IIB, Grade 2, 0/4 nodes, ER+/PR+ Dx 11/23/2012, DCIS, <1cm, Stage II, Grade 2, 0/4 nodes, ER+/PR+ Dx 11/23/2012, ILC, <1cm, Stage IIB, Grade 2, 0/4 nodes, ER+/PR+ Dx 11/23/2012, IDC, <1cm, Stage IIB, Grade 1, 0/4 nodes, ER+/PR+ Surgery 11/23/2012 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 2/6/2013 AC + T (Taxol) Hormonal Therapy 5/1/2013 Surgery 9/12/2013 Prophylactic mastectomy: Right
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Apr 6, 2015 03:46AM SugarCakes wrote:

Rdrunner, it is available to stream on Amazon for $8.99. I watched the first part last night and tonight. I haven't checked, but it's likely available on iTunes as well

43 years old Dx 1/20/2015, IDC, Left, 4cm, Grade 3, ER-/PR-, HER2+ Targeted Therapy 2/2/2015 Perjeta (pertuzumab) Targeted Therapy 2/2/2015 Herceptin (trastuzumab) Chemotherapy 2/2/2015 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 7/6/2015 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 9/9/2015 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 10/6/2015 Whole-breast: Breast
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Apr 25, 2015 04:41AM Sinsin wrote:

Marilynn, with three primary cancers, have you had genetic testing and testing done for othe illness, some rare, that can cause one to have high probability of multiple cancer diagnosis. If not, please have your MO look into it

I follow the Nemo Mantra, "Just keep swimming." Dx 1/14/2014, IDC, Stage IIB, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 2/12/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin) Chemotherapy 4/28/2014 Taxol (paclitaxel)
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Jun 11, 2015 03:27AM Yeg9525 wrote:

I was diagnosed with poorly differentiated stage IIIB signet ring Adenocarcinoma in my colon that originated from my appendix. I was very lucky that it did not make it to the peritoneum where it would have seeded and spread mucous throughout my abdomen. It was found in 4 of 18 nodes tested...I am currently NED for the SRC - it is a rare Cancer.

Dx 3/27/2015, DCIS, Left, 3cm, Stage 0, ER+/PR+ Surgery 7/27/2015 Mastectomy: Left, Right; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap
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Jun 11, 2015 06:10AM Pessa wrote:

Wonderful to hear you are NED.

Dx 2/20/2010, IDC, <1cm, 0/3 nodes, ER+/PR-, HER2- Chemotherapy 5/5/2010 AC Surgery 10/22/2010 Lumpectomy: Right; Mastectomy: Right; Prophylactic mastectomy: Left Hormonal Therapy 11/20/2010 Arimidex (anastrozole)
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Jun 11, 2015 06:29AM Suladog wrote:

a second primary cancer in my one remaining breast 25 yrs after the first one. It was dx last Oct.

Dx 6/6/1990, IDC, Left, <1cm, Stage IA, Grade 3, 0/18 nodes, ER-/PR-, HER2- Surgery 7/20/1990 Mastectomy: Left Chemotherapy 8/19/1990 CMF Dx 10/5/2014, IDC, Right, <1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2+ (FISH) Surgery 10/28/2014 Mastectomy: Right Chemotherapy 1/28/2015 Taxol (paclitaxel) Targeted Therapy 1/29/2015 Herceptin (trastuzumab) Hormonal Therapy 5/30/2015 Arimidex (anastrozole)
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Jun 11, 2015 09:20AM Sinsin wrote:

Congrats Yeg on being NED! Pop the bubbly and celebrate and may you continue to always be NED!

I follow the Nemo Mantra, "Just keep swimming." Dx 1/14/2014, IDC, Stage IIB, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 2/12/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin) Chemotherapy 4/28/2014 Taxol (paclitaxel)
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Jun 25, 2015 07:38PM jackie99 wrote:

I have cervical cancer also

Surgery 2/19/2002 Lumpectomy: Left Dx 12/9/2012, IDC, Left, 6cm+, Stage IV, metastasized to bone/liver/lungs, Grade 2, 3/15 nodes, ER+/PR-, HER2+ Chemotherapy 12/18/2012 AT Hormonal Therapy 1/2/2013 Liquid tamoxifen (Soltamox), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 1/21/2013 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Silicone implant Chemotherapy 6/30/2013 Carboplatin (Paraplatin) Radiation Therapy 12/1/2013 External: Bone
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Dec 27, 2015 06:56AM jdfly wrote:

2009 dx with lung cancer and had middle right lobe removed. 2015 dx with breast cancer doing chemo to shrink tumor

Dx 11/3/2015, IDC, Left, 5cm, Stage IIB, Grade 1, 2/2 nodes, ER+/PR+, HER2- Chemotherapy 11/23/2015 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 4/1/2016 Lumpectomy: Left; Lymph node removal: Sentinel, Underarm/Axillary Surgery 4/15/2016 Lumpectomy: Left Radiation Therapy 5/18/2016 Whole-breast: Breast, Lymph nodes
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Dec 13, 2016 01:18AM pepper43 wrote:

A PET scan after bc dx showed a suspicious mass in my right kidney. A follow up CT scan and urologist visit later and I'm 95% likely to be dealing with renal cell carcinoma. The mass is 6.5 cm. Given the size, my kidney will be removed next month.

Dx 6/9/2016, IDC, Right, 2cm, Stage IIB, Grade 3, 1/4 nodes, ER+/PR+, HER2- Chemotherapy 6/24/2016 AC + T (Taxol) Hormonal Therapy 11/19/2016 Surgery 12/9/2016 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Radiation Therapy 2/7/2017 3DCRT: Lymph nodes, Chest wall
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Dec 13, 2016 06:05AM Pessa wrote:

Pepper 43, Hope the mass is confined to the kidney and that the surgery goes well

I just had the right middle lobe of my lung removed for a new primary lung cancer, one month ago. I had the right upper lobe removed 3 years ago for a lung cancer. They do not think the 2 are related(not a metastasis), which is a good thing, I also had a melanoma 23 years ago, and, of course, the breast cancer 6 years ago. Enough already!

Dx 2/20/2010, IDC, <1cm, 0/3 nodes, ER+/PR-, HER2- Chemotherapy 5/5/2010 AC Surgery 10/22/2010 Lumpectomy: Right; Mastectomy: Right; Prophylactic mastectomy: Left Hormonal Therapy 11/20/2010 Arimidex (anastrozole)
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Jan 31, 2017 11:57AM DSW1976 wrote:

I haven't been on these boards in a long time is sorry for the delay in response. I was diagnosed with malignant melanoma this past July.

Someone always has it worse no matter how hard it seems.. Dx 9/18/2014, IDC, Right, <1cm, Stage IIA, Grade 2, 1/11 nodes, ER+/PR+, HER2+ (FISH) Dx 9/18/2014, DCIS, Right, <1cm, Stage 0, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 11/2/2014 AC Targeted Therapy 12/29/2014 Herceptin (trastuzumab) Chemotherapy 12/29/2014 Taxol (paclitaxel) Chemotherapy 1/3/2015 AC + T (Taxol)
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Feb 1, 2017 11:12AM Traveltext wrote:

Two years after my breast cancer treatment, I was diagnosed with prostate cancer. So I've had a mastectomy and a prostatectomy and am NED for both diseases. Phew!


One percent of those newly diagnosed with breast cancer are guys. I'm one of those. Recently diagnosed and treated for prostate cancer. Now NED for both. More on Male BC here. Dx 3/6/2014, IBC, Left, 2cm, Stage IIIB, Grade 2, 2/23 nodes, ER+/PR+, HER2- Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 7/28/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Radiation Therapy 9/14/2014 Breast, Lymph nodes Hormonal Therapy 11/3/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 1, 2017 05:13PM lekker wrote:

This thread isn't very active (I hope that's a good thing and it means there aren't a lot of us who've been "gifted" in this way). Sorry to see traveltext and DSW here. I hope whatever treatments you have to endure are tolerable and work

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Feb 1, 2017 07:28PM Lisey wrote:

DSW, another melanoma survivor here. (I was stage 1). You may want to look into genetic testing as there is a familial melanoma gene (all of the cousins and I have MM). Also, In doing research, I found some studies showing that some melanomas are estrogen positive.

Oncotype =20, ER 95%, PR 5%, ki67= 30%, Mammoprint = Low, Blueprint = Luminal A!!!! TEs= Iron Bra of Death - not worth all the complications for foobs that I'll never feel. Flat and fealess now. Dx 5/11/2016, IDC, Right, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR+, HER2- Surgery 6/1/2016 Lymph node removal: Sentinel Surgery 6/14/2016 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 7/7/2016 Mastectomy: Left, Right Hormonal Therapy 7/14/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 1, 2017 10:31PM Charlene1 wrote:

throat cancer oct 2015

breast cancer June 2016


Pet scan after treatment for throat cancer revealed breast cancer

diagnosed 10/15 throat cancer treatment 3 chemo 35 radiation, June 2015 PET scan revealed throat cancer was gone, but pin prick spot showed up in left breast, and so another journey begins Dx 6/28/2016, IDC, Left, <1cm, Stage IB, Grade 3, 1/4 nodes, ER+/PR+, HER2- Surgery 8/25/2016 Lumpectomy: Left Chemotherapy 10/6/2016 Taxol (paclitaxel) Hormonal Therapy Radiation Therapy Whole-breast: Breast, Lymph nodes Radiation Therapy Whole-breast: Breast, Lymph nodes
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Feb 22, 2017 02:29PM Ojttocs wrote:

Hey Breast and Thyroiders:

I'm having trouble with mets, and there is some indication that my thyroid meds are partially to blame. If I try to keep the thryoid cancer suppressed, I am having recurrence and mets with the breast cancer. My radiation onc thinks there's something to that.

Are you having that problem? How are your docs treating you?

TIA,

ojttocs

Dx 12/24/1996, IDC, Left, <1cm, Stage IA, Grade 1, 0/23 nodes, ER+ Surgery 1/19/1997 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Dx 9/14/2014, IDC, Left, 1cm, Stage IB, Grade 2, 0/1 nodes, ER+/PR+, HER2- Chemotherapy 12/17/2014 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 12/17/2015 Mastectomy: Right Dx 9/25/2016, IDC/IBC, Both breasts, 1cm, Stage IV, metastasized to other, ER+/PR+, HER2+ (IHC) Chemotherapy 10/19/2016 Navelbine (vinorelbine) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy CMF Radiation Therapy Whole-breast Targeted Therapy 10/20/2017 Perjeta (pertuzumab)
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Feb 22, 2017 03:44PM mike3121 wrote:

My wife 3 types of BC: ER/PR+HER2-, 100% erstrogen, grade 1, ER/PR+HER2-, 30% erstrogen, (grade 3 which was in the center of the grade 1 tumor) and triple negative metaplastic BC in her lymph nodes.

After a year NED on tamoxifen PET scan shows numerous mets to spine. Biopsy Monday but oncologist said probably Xeloda next treatment. He fears it's the triple negative come back.

Mike W.

Dx 11/12/2012, IDC, Right, 4cm, Stage IV, metastasized to bone, Grade 1, 9/19 nodes, ER+/PR+, HER2- Hormonal Therapy Aromasin (exemestane), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall Chemotherapy AC Surgery Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Right
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Feb 22, 2017 05:48PM Jesika63 wrote:

hi everyone- After 2 years of BC dx.., i was just diagnosed with follicular lymphoma. My lymphoma was found during a CT for diverticulitis. There are quit a few ladies i have met at the Oncologist office with this same dx. I also take synthroid for my thyroid (for over 20 years) Hope these cancers don't find their way to my thyroid. I agree with CT picking up just about everything in your body. Good or bad.

Seems like this boards is getting active after all. :((


Dx 1/12/2015, DCIS, Left, <1cm, Stage 0, Grade 1, 0/1 nodes, ER+/PR+, HER2- (FISH) Radiation Therapy 2/10/2015 Surgery Lumpectomy: Left; Lymph node removal: Left, Sentinel Hormonal Therapy Arimidex (anastrozole)
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Feb 22, 2017 07:18PM lekker wrote:

It sure is getting active. Does anyone here have any idea why they are experiencing multiple cancers? Genetic syndrome? Toxin exposure? Treatment for one cancer causing another? I did the Broca genetic panel out of the University of Washington. Back then they tested 40 known/suspected cancer-associated genes and I had no mutations whatsoever. Maybe it's something they haven't discovered yet. My older brother has never had cancer so I doubt it was some massive toxin exposure in childhood. And my colon cancer was caught so early I didn't even need surgery (removing the polyp was enough). Just bad luck??

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Mar 7, 2017 06:46AM DSW1976 wrote:

Breast and less than two year later acral lentiginous melanoma a rare malignant melanoma on my heel. I am still trying to heal from surgery from in july 2016 .. Melanoma is a beast of a cancer too.

Someone always has it worse no matter how hard it seems.. Dx 9/18/2014, IDC, Right, <1cm, Stage IIA, Grade 2, 1/11 nodes, ER+/PR+, HER2+ (FISH) Dx 9/18/2014, DCIS, Right, <1cm, Stage 0, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 11/2/2014 AC Targeted Therapy 12/29/2014 Herceptin (trastuzumab) Chemotherapy 12/29/2014 Taxol (paclitaxel) Chemotherapy 1/3/2015 AC + T (Taxol)
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Mar 7, 2017 02:25PM proudtospin wrote:

Guess I am dif as my bc just spread to liver

iris Dx 6/2008, DCIS, Stage 0, ER+
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Mar 19, 2017 01:16AM IllinoisNancy wrote:

Hi,

I was diagnosed with breast cancer in 2006 with recurrence in 2010 and 2016. I was diagnosed with NETS (Carcinoid) cancer in 2015 that started in my stomach and spread thru my nodes into my liver before I even knew I had it. I'm currently being treated for both. Ibrance and Femara for breast cancer and Sandostatin injections for NETS. My doctors tell me that I'm really a rare case and don't even know anyone else with my combination. Please let me know if any of you have.

Thanks much,

Nancy

2006 ILC in left breast

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