Jan 7, 2019 07:34AM Salamandra wrote:
I hadn't seen the Magee calculator before. I never got a ki-67, but I do already know my oncotype score (9). I was wondering if I could 'backwards engineer' the ki-67 that way.
Playing around with the info from my pathology report (100% strong estrogen, 90% moderate progesterone, grade 6 Nottingham), it is impossible to come close to my oncotype score even if I put the ki-67 at 0.01%. The 3 equations go 12 (eq3, which ignores the Nottingham),14 (Eq1, which uses everything), and 16 (eq 3, which ignores the ki-67 - and is the only one I could calculate without entering a ki-67). So I don't think ki-67 can really be determinative.
On the one hand, these are all too high. On the other hand, 18 and under is considered low risk, and they are all low risk, so for practical purposes of deciding chemo or not, it would have got me to the exact same place.
They don't send the whole tumor to oncotype... so oncotype is getting, I think, more of a biopsy sized part of the tumor. My biopsy pathology was definitely more favorable than my lumpectomy pathology - it was higher PR and only grade 1. So I was a bit worried that oncotype could also be deceptively favorable. On the other hand, DNA is DNA. Right?? I wish I had more science background now. But my DNA from the tiniest sample or a large sample should be the same, is that accurate?