We are 226,001 members in 82 forums discussing 158,562 topics.

Help with Abbreviations

Topic: Confused

Forum: Immunotherapy - Before, During, and After —

Discuss your experiences with the benefits, risks, and side effects of immunotherapy treatment for breast cancer.

Posted on: Oct 15, 2018 05:53PM

Mudpie wrote:

All,



I'm confused. Is there effective immunotherapy for breast cancer or not. I cant really find anything substantial on the internet. My Onc Doc said there isn't anything truly valuable yet.



I have stage IV er+ pr ductal carcinoma. Mets to bones. I am quickly becoming multi-treatment resistant. The last 4 or 5 meds have crapped out shortly after treatment or not worked at all. I'm in the market for a new path even if its a trial.



Mudpie

Log in to post a reply

Page 1 of 1 (17 results)

Posts 1 - 17 (17 total)

Log in to post a reply

Oct 15, 2018 06:01PM Meow13 wrote:

Hi Mudpie, my oncologist said we aren't there yet. I believe there maybe BCO members who have had trial immunotherapy. Look on the stage 4 topics, I think traditional treatment must be tried first. It is very upsetting I know it makes so much sense to target the cancer cells instead of blanket poison to kill fast growing cells. From what I have read using a patients own modified T cells is a risky business as they can attack healthy organs.

Commercials on tv are upsetting making it sound we are so far along with cancer treatment we are NOT.

Since you have had failure on 4 to 5 drugs you may qualify for a study.

Log in to post a reply

Oct 16, 2018 01:25PM - edited Oct 16, 2018 01:26PM by rdeesides

There absolutely are some immunotherapies that are working. I know someone who was Stage 4, with very advanced disease from what I understand, that is now NED due to Opdivo. However, it is not standard of care yet. Also, it won't help everyone. However, for those it does help, it is a miracle. You can only get access to it through cinical trials at this point. Maybe take a look through www.cinicaltrials.gov, to see if you find anything that looks like a good fit.

Rebekah

Dx 6/24/2017, IDC: Medullary, Right, 2cm, Stage IIA, Grade 3, 0/2 nodes, ER-/PR-, HER2- (IHC) Dx 7/3/2017, IDC, Right, 1cm, Stage IIA, 0/2 nodes Chemotherapy 8/15/2017 AC Chemotherapy 10/11/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery 1/15/2018 Mastectomy: Right; Reconstruction (right): Tissue expander placement Radiation Therapy 2/21/2018 Whole-breast: Breast, Chest wall Chemotherapy 5/4/2018 Xeloda (capecitabine) Surgery 12/12/2018 Reconstruction (right): DIEP flap
Log in to post a reply

Oct 16, 2018 02:29PM Mudpie wrote:

Thank You, please add if you hear anything more.

Log in to post a reply

Oct 16, 2018 02:30PM Mudpie wrote:

Thank You, I cant find a clinical related to Opdivo, unless I am looking in the wrong place.

Log in to post a reply

Oct 16, 2018 04:08PM LoriCA wrote:

Mudpie for Opdivo trials you need to search for nivolumab. I found 31 breast cancer trials currently recruiting.

There are some passive immunotherapy drugs approved for breast cancer. Herceptin, Perjeta, and Kadcyla (TDM-1) are considered passive immunotherapies, as is Opdivo. Those are the only three currently approved that I am aware of unless something else has very recently been approved. Unfortunately only about 20% of us are HER2+ and can take advantage of them (and I give thanks every day that I'm in the 20%). Your profile isn't visible (or hasn't been added) so I don't know your HER2 status or what treatments you've previously had.

I don't think that Keytruda, a check point inhibitor immunotherapy, has been approved for breast cancer yet, but it seems close and promising for TNBC.

There's nothing approved yet (AFAIK) for people who are not HER2+, nothing approved yet in the way of active immunotherapy, no CAR T cell therapies approved for solid tumors yet, no approved checkpoint inhibitors. It's all still in research. A quick check of clinical trials found 93 active trials for breast cancer immunotherapy (66 currently recruiting) so it might be worth a look at more than just nivolumab.

IBC Stage IV de novo - mets throughout skeleton, liver, distant nodes, chest wall, skin, tumor in brachial nerves.Still trying to get it to slow down. Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/26/2017 Taxol (paclitaxel) Targeted Therapy 2/6/2018 Perjeta (pertuzumab) Targeted Therapy 2/6/2018 Herceptin (trastuzumab) Chemotherapy 11/26/2018 Taxol (paclitaxel) Radiation Therapy 1/30/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
Log in to post a reply

Oct 16, 2018 10:21PM urdrago71 wrote:

Keytruda is still going thru trials level III. I just was offered the opportunity to sign up doesnt mean I will be picked..


Stay strong, make them wonder how you're still smiling! Dx 3/2/2018, IDC, Right, Stage IIIB, Grade 3, 2/18 nodes, ER-/PR-, HER2- (DUAL) Chemotherapy 4/4/2018 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide) Chemotherapy 5/30/2018 Taxol (paclitaxel) Surgery 10/4/2018 Lumpectomy: Right; Lymph node removal: Underarm/Axillary Radiation Therapy 11/12/2018 Whole-breast: Breast, Lymph nodes Chemotherapy 1/17/2019 Xeloda (capecitabine)
Log in to post a reply

Oct 16, 2018 10:58PM Parrynd1 wrote:

I was on an Immunotherapy trial called IPI 549 and I believe it’s still enrolling if you qualify. It pairs the study drug with Opdivo (aka Nivolumab). I was also on a PARP inhibitor trial in 2016/17 that worked really well. You might want to check for either. Good luck. Hu

Dx 9/4/2016, IDC, Right, 4cm, Stage IIIA, Grade 3, ER-/PR-, HER2- Chemotherapy 11/29/2016 Other Chemotherapy 2/21/2017 AC Surgery 5/17/2017 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 6/14/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Radiation Therapy 10/4/2017 Whole-breast: Breast, Lymph nodes Dx 3/2018, IDC, Right, 5cm, Stage IV, metastasized to brain/bone/lungs/other, Grade 3, 1/1 nodes, ER-/PR-, HER2- Radiation Therapy 5/23/2018 External: Brain Chemotherapy 6/27/2018 Other Targeted Therapy 10/1/2018 Avastin (bevacizumab) Radiation Therapy 12/28/2018 Whole-breast: Breast Chemotherapy 12/30/2018 Halaven (eribulin) Dx 1/29/2019, IDC, <1cm, Stage IV, metastasized to other, Grade 3, 1/1 nodes, ER-/PR-, HER2- (FISH) Dx 2/5/2019, 3cm, Stage IV, metastasized to brain, Grade 3, ER-/PR-, HER2- (FISH) Surgery Chemotherapy Other
Log in to post a reply

Oct 17, 2018 09:33AM Mudpie wrote:

Thank You. What is TNBC?

I have stage IV er+ pr ductal carcinoma. Mets to bones.

No Herp2

Log in to post a reply

Oct 17, 2018 09:35AM Mudpie wrote:

Thank You.

Log in to post a reply

Oct 17, 2018 11:39AM LoriCA wrote:

TNBC is triple negative breast cancer = ER- PR- HER2-.

Good luck getting into that trial urdrago71!

Parrynd1 was the parp inhibitor talazoparib (Talzenna)? That just received FDA approval yesterday for BRCA-mutated HER2-.

IBC Stage IV de novo - mets throughout skeleton, liver, distant nodes, chest wall, skin, tumor in brachial nerves.Still trying to get it to slow down. Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/26/2017 Taxol (paclitaxel) Targeted Therapy 2/6/2018 Perjeta (pertuzumab) Targeted Therapy 2/6/2018 Herceptin (trastuzumab) Chemotherapy 11/26/2018 Taxol (paclitaxel) Radiation Therapy 1/30/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
Log in to post a reply

Oct 17, 2018 06:17PM Parrynd1 wrote:

Lori- Yes, it was! I was only on it for 3 months (was only stage 3 at the time) so that was the length of the trial. In that time it cleared my lymphnode, and secondary tumor. It also shrunk my big 4.5cm tumor in half. Plus the only SE’s I had were some mild daily nausea, and thinning hair. I hope to go back to it in the future.

Dx 9/4/2016, IDC, Right, 4cm, Stage IIIA, Grade 3, ER-/PR-, HER2- Chemotherapy 11/29/2016 Other Chemotherapy 2/21/2017 AC Surgery 5/17/2017 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 6/14/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Radiation Therapy 10/4/2017 Whole-breast: Breast, Lymph nodes Dx 3/2018, IDC, Right, 5cm, Stage IV, metastasized to brain/bone/lungs/other, Grade 3, 1/1 nodes, ER-/PR-, HER2- Radiation Therapy 5/23/2018 External: Brain Chemotherapy 6/27/2018 Other Targeted Therapy 10/1/2018 Avastin (bevacizumab) Radiation Therapy 12/28/2018 Whole-breast: Breast Chemotherapy 12/30/2018 Halaven (eribulin) Dx 1/29/2019, IDC, <1cm, Stage IV, metastasized to other, Grade 3, 1/1 nodes, ER-/PR-, HER2- (FISH) Dx 2/5/2019, 3cm, Stage IV, metastasized to brain, Grade 3, ER-/PR-, HER2- (FISH) Surgery Chemotherapy Other
Log in to post a reply

Oct 17, 2018 08:57PM LoriCA wrote:

That's awesome Parrynd1! I know that TNBC is a tough combination to treat and I'm sure everyone is happy to see another successful drug approved for it. Must be a great feeling to know that you played a part in getting it approved - and that you had such a fantastic response.

Lori

IBC Stage IV de novo - mets throughout skeleton, liver, distant nodes, chest wall, skin, tumor in brachial nerves.Still trying to get it to slow down. Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/26/2017 Taxol (paclitaxel) Targeted Therapy 2/6/2018 Perjeta (pertuzumab) Targeted Therapy 2/6/2018 Herceptin (trastuzumab) Chemotherapy 11/26/2018 Taxol (paclitaxel) Radiation Therapy 1/30/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
Log in to post a reply

Oct 18, 2018 01:15AM - edited Oct 19, 2018 01:12AM by Meow13

Happy to hear there are some new drugs out there.

Log in to post a reply

Oct 18, 2018 02:37PM - edited Oct 18, 2018 02:39PM by Mudpie

So, since I am confused, Im trying to pair this down to the simplest of terms:


Immunotherapy trials are only for Herp2+ patients, or Triple Negative patients.


Is that correct?

Please correct if I'm wrong. Alot of the verbage is throwing me off.

Log in to post a reply

Oct 18, 2018 04:31PM LoriCA wrote:

Not always, you have to read the inclusion/exclusion criteria for each trial. For example, the Phase II trial for Pembrolizumab is only for people who are HR+, HER2-.

Do you know your HER2 status? It's either positive, negative or equivocal and it's important to know because it plays a major role in your treatment. You should know three things from your pathology - HR positive or negative, PR positive or negative, and HER2 positive/negative/equivocal.

IBC Stage IV de novo - mets throughout skeleton, liver, distant nodes, chest wall, skin, tumor in brachial nerves.Still trying to get it to slow down. Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/26/2017 Taxol (paclitaxel) Targeted Therapy 2/6/2018 Perjeta (pertuzumab) Targeted Therapy 2/6/2018 Herceptin (trastuzumab) Chemotherapy 11/26/2018 Taxol (paclitaxel) Radiation Therapy 1/30/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
Log in to post a reply

Oct 18, 2018 07:09PM - edited Oct 18, 2018 07:26PM by Mudpie

Thank You.

I know all the details of my diagnosis.

I've actually written them a few times in the thread and on my origional post.

On my end, the site is kind of glitchy and my posts turn up in areas that aren't nested under the questions I'm trying to answer. Also, in Chrome a drop down menu covers the “send" icon so I cant send a reply back n Chrome, at all.

I was diagnosed with Invasive Ductal Carcinoma ER+ PR+ HER-

I had a 9 year period with no diease.

Came back to bones, now stage IV.

My confusion is only about the clinical trials because this is my first investsgation them.

I hope this post can be seen, seems like computer gremlins got a hold of a few of my responces.

Mudpie

Log in to post a reply

Nov 6, 2018 05:54AM - edited Nov 6, 2018 05:57AM by Kattysmith

Mudpie, I'm in a similar boat. Stage IV since 2015, now with very active mets in my liver and standard treatments haven't been cutting it. I've just been recruited by MD Anderson for a Phase 1 clinical trial that pairs Nivolumab with a brand new drug known only by its initials so far. I was preparing to qualify a different trial there, but an opening suddenly came up and my doctor thought this would be an even better option, so I took the plunge and signed consent. And boy, does it feel like a plunge off a scenic cliff with an unfamiliar parachute!!! Assuming my insurance approves my participation, I'll have a battery of tests to see if I qualify. I am ER/PR+ / HER-, but my liver tumors (liver mets were discovered last spring) have a couple of mutations, so I'm not 100% sure what's happening there.

The only thing that really bothers me is that I had my last (ineffective, unfortunately) treatment in late September. My scan was in the 3rd week of October and that's when the plan changed, and standard treatments were off the table. Now, it will be about 3 more weeks before all of my tests are done and I find out if I can join this trial. My liver mets are very active; they are partying down in there, so I will have been without any treatment for several weeks. Fortunately,as of this moment my blood work is great, my overall health is great, I have no pain or edema...so far. But still...yikes. Three weeks is a long time to hold my breath!

First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/4/2015 AC Hormonal Therapy 2/5/2016 Femara (letrozole) Targeted Therapy 2/5/2016 Ibrance (palbociclib) Immunotherapy 12/23/2018 Hormonal Therapy Faslodex (fulvestrant)

Page 1 of 1 (17 results)