Immunotherapy Tecentriq Helps Some Advanced-Stage Triple-Neg

I started Chemo plus Tecentriq this past Monday. Curious if anyone else here has. I’m a Stage 4 TNBC with skin Mets. So far so good.

I started Tecentriq and Abraxane two weeks ago. Curious to here how you guys are doing. Did you have any bad side effects. Are you still taking this treatment

Hi Amscott,

I am starting Tecentriq and Abraxane in a couple of weeks. How has this treatment worked for you?

Thank you for sharing your experience.

Sherry

I will also be starting this combo later this month...anxious to hear how you all are doing !

Hi there I I was diagnosed as well with tnbc in January of last year and had a Reoccurrence in July of this year I started the Abraxane I've done three rounds and I am due to start tecentriq Thursday what would you say your side effects are from that to tecentriq

i have been on abraxane and tecentriq since april of this year...i do the tecentriq portion every other friday(twice a month)...most of my side effects have been from the abraxane also....the only side effects i have experienced from the tecentriq is that it lowered my potassium..so i am currently taking potassium tablets now...i also have a rash on my leg..it doesn't itch at all...just those 2 so far...but I had real good pet scan in June...my body is responding to the abraxane and tecentriq.:)

Hi,

I have a black rash on the outside of my leg, below my knee and whats weird is, that it doesn't itch at all...I asked my oncologist was it a rash and he was like, yes its a rash and its a side effect from the tecentriq because it was localized to that one place. Sorry that your's is itching and burning. Definately speak with your oncologist about it, hopefully they can prescribe you something to give you some relief:)

thanks for the insight got sone relief gonna talk to my oncologist tomorrow blessings to

I have noticed we are all metastatic tnbc. I feel like I learn so much from this site. Have any of you considered trials or other treatment options? I felt good while on the abraxane and tecentriq but recently had some slight tumor growth and my onc wanted to change treatment to stay ahead of it. We discussed trials, Gem/carb combination or Xeloda. I took Xeloda after my stage 3 treatment and did well so I chose that option for quality of life. I’m starting to question my decision.. i wasn’t expecting the news and made a quick decision. I am researching trials and nothing is standing out. It’s a little overwhelming. I was wondering if others had insight on trials for tnbc or other treatment options.

Marta, I am sorry to hear about your diagnosis’s. welcome to this site. I hope you will find the shared experiences and support you need here. I am also glad that you are extending treatment to prevent reoccur ace with the trial. I found the ac and taxol to be the hardest for me. I found the radiation to be easy until the last week or so of treatments. I did burn that last week but after radiation was complete I healed quickly. So that is a positive. I also felt fairly good and found the immunotherapy treatment much easier than the initial treatments ac and taxol treatments. Hang in there. The treatments will go by quicker then you think.best of luck and keep us posted on your success and completion of each step in the process

Martaj I had exactly the same situation as you, and a good response to chemo as well. My axillary node persisted longer than my tumor but it too went away. May I recommend HEAT. Look up Hyperthermia. Very simple for an aillary node right there at the surface. Heat the F out of it a couple of times per week. You need to get it to apx 108 degrees for about an hour. Healthy cells will not be damaged but it really damages (or kills) malignant cells to get this hot. They put out "heat shoc protein" which removes their invisibility to your immune system. Lots of benefit, free, and no SE.

105 is the hottest possible hot tub (which I love)... So I could imagine a few degrees past that to YIKES. I had a magenta-colored side boob and armpit (very mild burns) through chemo due to all the heat. But it all healed fine and looks perfectly normal now. It's very low tech to use a hot hot hot water bottle but that's what veterinarians do if an animal has a tumor they need to shrink, so that's what I did. 3x per week+ especially the day before the chemo. It won't hurt and it might help!!

My wife is scheduled to begin treatment on Tecentrig as soon as they find an alternative to the abraxane (taxol). She's had a violent allergic reaction to taxol. She is TNBC as her ER/PR+ turned TNBC when taking Xeloda. She was doing fine on Halaven when the cancer went to her brain. Brain surgery followed by whole brain radiation. While all this was taking place the cancer (bone mets only) was growing. She's very frail now and her Dr. wanted to know if she even wanted to try anything else. According to her Dr. this is her last chemo, her body can't take much more.

What are alternatives to the abraxane (taxol)? My wife has very high PDL-1, and with the right chemo, this treatment could be very successful for her.

Santabarbara, I don't know if she was tested for androgen receptors. What is the relation to Tecentrig? She had the Foundation 1 BRACA 1 & 2 testing - Negative. She had a Strata Test and the only thing was a very high PDL-1. If no alternative is found for the Taxol it's probably Hospic care for her. I'm just numb from it all.

I have TNBC estrogen, progesteron HERS neg. Stage 3, So far I have had 10/12 taxol infusions, 4 carboplatin infusions, 4 Tecentrig/palcebo, After 12th taxol, move on to 4 doses in 8 week period of adrianmycin, and cytoxan, then surgery then radiation. Every 3 weeks tecentnig/palcebo for a year. Breast tumor has disappeared, so something is working

My wife's (TNBC) Oncologist attributes her exhaustion to the cancer. However, from what I've read it's more likely from the Whole Brain Radiation (WBR) she's had, not to mention the brain surgery. She's frail and not much interested in food so I have to play bad nurse Rachet to get her to eat.

It seems my wife has a very high PDL-1 which would fit in perfectly with a new recently FDA approved Atezolizumab or Tecentriq. This new drug has few side effects, just perfect for my frail wife. However, it's best and most effective when taken with the recommended chemo paclitaxel. My wife is horribly allergic to taxol and almost died in the infusion room from it. So it's the old rock and a hard place. With Atezolizumab the higher the PDL-1 the more successfully it works. Yet there's the taxol. Her Kaiser Permanente Oncology is really going the extra mile for her. I found out just yesterday they are going to have a meeting between some Pharmacy people and some of her Oncology staff. They are confident they can find an alternative to Taxol.