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Topic: Herceptin / Chemotherapy and Heart Damage?

Forum: Immunotherapy - Before, During, and After —

Discuss your experiences with the benefits, risks, and side effects of immunotherapy treatment for breast cancer.

Posted on: Nov 6, 2018 09:55AM

RebzAmy wrote:

Did anybody find out that their treatment had affected their heart some years down the line, and if so how? I'm currently being investigated for high blood pressure and a very fast heart rate (which started suddenly and resolved by the next day). I've had various tests and scans and am currently wearing a 24-hour heart trace monitor and a 24-hour blood pressure monitor. I had my treatment from 2007-2008. Thanks

Diagnosed June 2007, IDC, Grade 3, 4-5cm lump, several lymph nodes involved, HER2+++, 4 months of high strength chemo, mastectomy and lymph node removal, radiotherapy & a year of herceptin and recently had preventative surgery to other breast.
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Dec 19, 2018 11:08PM leftfootforward wrote:

Herceptin effected my heart- it lowered my ejection fraction of my left ventricle such that I was almost in co festive heart failure. I had to stop treatmentbwith herceptin. Fortunately, my heart function returned to normal over time.

I am on a beta blocker and ace inhibitor to help.


I tried herceptin again and same thing hapoened.

Good news is I recovered again.

Theee is a thicjeningbif mt heart muscle from all the meds.

I am still watched by a cardiooogist and have echo cardiograms about every 6 months.

Good luc

Dx 12/13/2010, IDC, 3cm, Stage IIIA, Grade 2, 1/16 nodes, ER-/PR-, HER2+ Dx 12/4/2012, IDC, Stage IV, 0/0 nodes, ER-/PR-, HER2+
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Dec 20, 2018 12:51AM illimae wrote:

I think about 12% have heart issues due to Herceptin but it tends to happen during active treatment. I do know of someone (triple negative), who developed heart damage due to the chemo drugs a couple years after completing their treatment.

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Targeted Therapy 1/2/2017 Perjeta (pertuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, 5cm, Stage IV, metastasized to brain, Grade 3, 3/13 nodes, ER+, HER2+ (IHC) Radiation Therapy 10/20/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/23/2019 External: Brain Surgery 1/22/2020 Radiation Therapy 2/17/2020 External: Brain Radiation Therapy 7/20/2020 External: Bone Radiation Therapy 12/4/2020 External: Brain Targeted Therapy Tukysa (tucatinib) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 9, 2021 05:44AM Dolly2019 wrote:

hi guys,

Just caught this thread when looking at info about Herceptin and heart damage.

My mum has just been told there is a slight change in the heart function due to Herceptin. They are going to give her a break this month from it.

Obviously my mum is devastated as she was happy in Herceptin and it was working so well.

My question is does this mean no more Herceptin ever or can the heart fix itself during a short break? If the break is taken does that not mean a bigger risk of cancer spreading further. So far mum has no sign of the cancer. It had been in her stomach but for last year has been gone from there thanks to Herceptin.

Also are there other treatments to use after this?

Dolly

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Oct 9, 2021 11:40AM illimae wrote:

Dolly, I had to take a break for about a month last year (not due to Herceptin itself but a Biosimilar called Kanjinti) and my EF got back to normal. I had echo’s before every treatment for months to monitor it but it stayed normal. I was also prescribed Carvidilol as protective med and have fully returned to normal a treatment and screening schedule. Good luck.

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Targeted Therapy 1/2/2017 Perjeta (pertuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, 5cm, Stage IV, metastasized to brain, Grade 3, 3/13 nodes, ER+, HER2+ (IHC) Radiation Therapy 10/20/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/23/2019 External: Brain Surgery 1/22/2020 Radiation Therapy 2/17/2020 External: Brain Radiation Therapy 7/20/2020 External: Bone Radiation Therapy 12/4/2020 External: Brain Targeted Therapy Tukysa (tucatinib) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 10, 2021 05:16AM AlwaysMeC wrote:

I hope this isn't a duplicate comment. Somehow I don't see the one I just wrote.

Ilimae, do you know what the values should be? I was told normal EF is 50 to 70. Mine has been steady at 55 to 60, but my GLS dropped from 19.6 pre chemo to 18.2 three months later, then 17.1 last week. Did your team monitor GLS? So far, I haven't heard back from my oncologist, but I know they wait until counts are dangerously low before they even consider any type of pause. I am currently on Herceptin/Perjeta.

Dx 4/2/2021, IDC, Left, 1cm, Stage IIA, Grade 2, ER-/PR-, HER2+ (FISH)

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