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Topic: Keytruda as preventative for TNBC

Forum: Immunotherapy - Before, During, and After —

Discuss your experiences with the benefits, risks, and side effects of immunotherapy treatment for breast cancer.

Posted on: Mar 9, 2019 10:53AM

PaulaAtlantaGA wrote:

I'm wondering if anyone here is on the medical arm of the Keytruda trial? I was lucky enough to get in, and I'm fighting fatigue in a way almost, but not quite, as bad as during chemotherapy, Could be two surgeries within 5 weeks (exchange TE and implant, then remove one implant due to cellulitis) as well as weeks of IV antibiotics. Anyone here in this trial?

DX 10/2017; Stage IIIA, Grade 3, 2 nodes, TNBC Chemo A/C 9/2017; 12 weeks taxol w 4 added 4 carboplatin 1/2018. Surgery 4/2018 included axillary node dissection with 2/14 nodes, 2 cm tumor remaining; radiation 6/2018, Xeloda 7/2018
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Mar 9, 2019 11:28PM JohnSmith wrote:

That's great that you're participating in a immunotherapy clinical trial. You might want to specify which trial since there about 100 different breast cancer trials using Pembrolizumab (Keytruda).

Wife was Age 45 at Dx 4/2014. BMX Surgery 6/2014 revealed: ILC, Stage 2 (Multifocal ILC, largest lesion 2.2 cm), Grade 2, ER+/PR+ (95%), HER2-, Ki-67 5-10%, Oncotype 11; Variant in the ATM gene Dx 4/8/2014, ILC, Left, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery 6/26/2014 Mastectomy; Reconstruction (left); Reconstruction (right)
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Mar 10, 2019 07:51AM BrinkOfEternity wrote:

I was on a pilot study with Abraxane and Keytruda, and honestly didn’t notice much SEs from Keytruda except some mild rashes. Most of the SEs (fatigue)I would attribute to Abraxane.

Weakly ER+ so practically TNBC, getting neoadjuvant chemo (Abraxane) with immunotherapy (Keytruda), then surgery, then more chemo (AC) Dx 7/26/2018, DCIS/IDC, Right, 3cm, Stage IIB, Grade 3, 0/5 nodes, ER+/PR-, HER2- (FISH) Chemotherapy 9/3/2018 Abraxane (albumin-bound or nab-paclitaxel) Surgery 12/27/2018 Lymph node removal: Sentinel; Mastectomy: Right; Reconstruction (right): Tissue expander placement Chemotherapy 2/3/2019 AC Surgery 4/26/2019 Reconstruction (right): DIEP flap
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Apr 4, 2019 11:11AM purplestargazer wrote:

I was on the Keytruda trial. The only side effect I had was an issue with my thyroid, which was easily corrected with medication.

Unfortunately it didn't work for me, as I had a local reoccurance.


Dx 6/12/2017, IDC, Left, 2cm, Stage IIA, Grade 3, ER-/PR-, HER2- Chemotherapy 7/9/2017 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxol (paclitaxel), Xeloda (capecitabine) Dx 3/12/2019, IDC, Left, 2cm, Stage IIA, Grade 3, ER-/PR-, HER2- Surgery 4/9/2019 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy 4/30/2019 Carboplatin (Paraplatin), Gemzar (gemcitabine)

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