Topic: Herceptin and Perjeta side effects after chemotherapy.

Forum: Immunotherapy - Before, During, and After — Discuss your experiences with the benefits, risks, and side effects of immunotherapy treatment for breast cancer.

Posted on: Dec 20, 2020 02:31PM - edited Dec 20, 2020 02:35PM by dlr68

Posted on: Dec 20, 2020 02:31PM - edited Dec 20, 2020 02:35PM by dlr68

dlr68 wrote:

I have been on Herceptin Hylecta and IV Perjeta mono therapy. I have 6 treatments left. I had more gastrointestinal issues while on chemotherapy (TCHP) than I did on HP mono therapy (no GI issues whatsoever for first 4 rounds of mono HP). However, since my last two HP treatments, my diarrhea has picked up. I also have upper abdominal pain-sometimes on the left and sometimes on the right. Nausea seems to be a factor on and off. I had upper endoscopy when I was diagnosed in March--no ulcers or H pylori. Bloodwork three weeks ago was normal. My oncologist says it's unusual for me to have normal gastrointestinal function after TCHP and then suddenly develop problems in the middle of HP. I have started back on Protonix (PPI) and Pepcid. Anybody out there experience the same? Thanks

Dx 3/2020, DCIS/IDC, Right, 2cm, Stage IIA, Grade 3, 1/6 nodes, ER+/PR+, HER2+, Surgery 3/27/2020 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
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Mar 24, 2021 11:47PM deniseml wrote:

thanks for eye drop info. Last chemo was 12/8 and still experiencing eye tearing so am using Thera-tears now. It has helped! Does this mean I have been left with dry eye syndrome?

Dx 8/3/2020, IDC/IBC, Left, 3cm, Stage IIIC, Grade 3, 0/7 nodes, ER-/PR-, HER2- Surgery 1/15/2021 Lymph node removal; Mastectomy; Mastectomy (Left) Immunotherapy Radiation Therapy Whole breast, Radiation boost: Lymph nodes, Chest wall Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
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Mar 25, 2021 11:22PM minustwo wrote:

Denise - I didn't think it was permanent. At least it wasn't for me. Since it's been 4 months, I'd definitely see what your MO says &/or make an appointment with an ophthalmologist.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Jul 28, 2021 10:02AM deniseml wrote:

I know this thread isn’t active right now, but, in case it’s viewed , I’m looking for anyone who experienced a worsening echocardiogram while on HP. I had to hold July dose for to a drop in my ejection fraction on echo. Can’t say I am feeling any different. Do you know if it will improve with holding a dose? Or can I expect to stop all infusions? I have 5 more to go, and this is concerning to me since there is no other recommended treatment for HER2+, IBC with pCR at time of surgery.

Dx 8/3/2020, IDC/IBC, Left, 3cm, Stage IIIC, Grade 3, 0/7 nodes, ER-/PR-, HER2- Surgery 1/15/2021 Lymph node removal; Mastectomy; Mastectomy (Left) Immunotherapy Radiation Therapy Whole breast, Radiation boost: Lymph nodes, Chest wall Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
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Jul 29, 2021 07:24AM melbo wrote:

sorry Denise — I don’t have any experience with heart issues from herceptin. I did want to share though that there have been studies showing that even six months of herceptin works — so even if you can’t finish the recommended number of Infusions it should still be okay. It does suck a lot though and I hope you will be able to pause and then finish the course.


https://www.breastcancer.org/research-news/herceptin-for-6-months-seems-same-as-1-yr

Diagnosed right before my 42nd birthday. One husband, two dogs, one cat and no kids. Dx 7/16/2020, IDC, Left, 2cm, Stage IIA, Grade 3, 1/7 nodes, ER-/PR-, HER2+ Targeted Therapy 8/7/2020 Herceptin (trastuzumab) Targeted Therapy 8/7/2020 Perjeta (pertuzumab) Chemotherapy 8/7/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/20/2020 Lumpectomy; Lumpectomy (Left); Lymph node removal; Reconstruction (Left); Reconstruction (Right) Radiation Therapy 1/31/2021 Whole breast: Breast, Lymph nodes
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Jul 29, 2021 08:29AM - edited Sep 9, 2022 12:12PM by deniseml

Melbo, thank-you for this information. I did not find this in my search! It does ease my mind a little to know it's been studied

Update: it’s a little over a year later. Continuing on cardiac meds. Heart muscle has slowly recovered. I opted not to finish HP treatment. NED to date. Just had PRM. Life moves on. Too many other things to take priority .

Hope & pray all of you are managing well and finding peace wherever you are at .

Dx 8/3/2020, IDC/IBC, Left, 3cm, Stage IIIC, Grade 3, 0/7 nodes, ER-/PR-, HER2- Surgery 1/15/2021 Lymph node removal; Mastectomy; Mastectomy (Left) Immunotherapy Radiation Therapy Whole breast, Radiation boost: Lymph nodes, Chest wall Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
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Sep 6, 2022 12:34PM bakerb wrote:

Last year I completed 6 rounds of TCHP and experienced diarrhea throughout. This was followed by herceptin and perjeta (Phesgo injection) to complete a full year of treatment. My last dose was one month ago and the diarrhea continues, so I’m guessing that the drugs are still circulating. The itchiness is still very bothersome but may be slightly less intense. I will post when these 2 side efffects are no longer an issue.

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