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Topic: TNBC locally advanced with PDL1 Negative

Forum: Immunotherapy - Before, During, and After —

Discuss your experiences with the benefits, risks, and side effects of immunotherapy treatment for breast cancer.

Posted on: Nov 11, 2021 03:19AM

RaviShankarP wrote:

Hi All,


My wife is going through chemotherapy (3rd one finished just now and 5 more to go) and initial lump of 7 cm size is now came to 1.7 cm...

PDL1 test came as 0% (negative) .

Can some one advice if immunotherapy is advisable for her along with chemo? And does that have any positive impact considering PDL1 is negative/ 0%.



Thanks in advance

Ravi





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Nov 11, 2021 11:06AM santabarbarian wrote:

My understanding is the immunotherapy benefits people with PDL1. I did not have PDL1 either.

Wonderful fast shrinkage - I had the same rapid shrinkage. Good news!

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/10/2019 Whole-breast: Breast, Lymph nodes
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Nov 11, 2021 01:32PM moth wrote:

Hi Ravi, the only current FDA approved immunotherapy for tnbc is pembrolizumab/Keytruda and it requires a pd-l1 score of >10

If pd-l1 is negative, the other thing to pursue is a one year course of capecitabine/Xeloda after surgery to lower risk of recurrence https://www.breastcancer.org/research-news/year-of...

Best wishes

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/2/2021 External: Bone

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