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Topic: Palbociclib, ribociclib or abemaciclib

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: Sep 28, 2019 02:40AM

RT0466 wrote:

Hi, trying to decide which of these to go for: Palbociclib, ribociclib or abemaciclib. Which is better for mean survival compared with standard anti-hormone therapy? Which drug has the safest profile with least side-effects and what does it actually guarantee in terms of life extension.

Facts, figures and experiences are welcome.

Thank you.

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Sep 28, 2019 06:07AM Moderators wrote:

Hi RT0466, and welcome to our community Medicating

Here are some pages from our site that you may find helpful:

Ibrance, Kisqali Verzenio.

And go here to find research news on these three as well:

You may want to use the Search box to the left in the blue bar to find topics on these as well.

Also from our site:

About Ibrance, Kisqali, and Verzenio

Ibrance, Kisqali, and Verzenio are cyclin-dependent kinase 4/6 inhibitors, commonly called CDK4/6 inhibitors. A kinase is a type of protein in the body that helps control cell division. CDK4/6 inhibitors work by stopping cancer cells from dividing and growing.

Ibrance, Kisqali, and Verzenio are used in combination with a type of hormonal therapy called an aromatase inhibitor as the first hormonal therapy to treat advanced-stage or metastatic, hormone-receptor-positive, HER2-negative breast cancer in postmenopausal women. Arimidex (chemical name: anastrozole), Aromasin (chemical name: exemestane), and Femara (chemical name: letrozole) are aromatase inhibitors.

Ibrance, Kisqali, and Verzenio also are used in combination with the hormonal therapy Faslodex (chemical name: fulvestrant) to treat advanced-stage or metastatic hormone-receptor-positive, HER2-negative breast cancer that has grown while being treated with a different hormonal therapy, in postmenopausal women.

Ibrance also may be used to treat men diagnosed with advanced-stage or metastatic hormone-receptor-positive, HER2-negative breast cancer.

Kisqali also may be used to treat premenopausal and perimenopausal women. Premenopausal and perimenopausal women treated with Kisqali also should be treated with a luteinizing hormone-releasing hormone agonist, such as Zoladex (chemical name: goserelin), to suppress ovarian function.

Verzenio also may be used alone to treat men or women diagnosed with hormone-receptor-positive, HER2-negative metastatic or advanced-stage breast cancer if the cancer has grown after hormonal therapy treatment and earlier chemotherapy for metastatic disease.

All three CDK4/6 inhibitors are pills taken by mouth.

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Sep 29, 2019 07:34AM RT0466 wrote:

Thank you moderators. I will do all the reading I can. But I was wondering what experiences people have had with these drugs (particularly perimenopausal women on zoladex and letrazole).

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Nov 17, 2019 05:23PM Lolis wrote:

Hi RT,

Hope you are well.

I have been almost 2 years on Kisqali and letrozole. I am taking Zaladex as well on a monthly basis. the first couple of months were a bit hard (hot flashes, moodiness, and sore joints and hair thinning) then my body adjusted and the tumor shrinked after 3 month on Kisqali. I have been stable since then and the side effects have subsided.

it is definitely worth a trial.

good luck with your choice.

First dx @ 33, mets @ lucky number is 3 😊 Dx 3/22/2014, DCIS, Left, 5cm, Stage 0, Grade 2, 8/24 nodes, ER+/PR+, HER2- Dx 3/22/2014, IDC, Left, 5cm, Stage IIIA, Grade 2, 8/24 nodes, ER+/PR+, HER2- Surgery 4/21/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 5/14/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Hormonal Therapy 9/10/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 9/28/2014 Breast, Lymph nodes Dx 12/6/2017, IDC, Left, Stage IV, metastasized to other, Grade 3, ER+/PR-, HER2- (IHC) Targeted Therapy 1/7/2018 Kisqali Hormonal Therapy 1/8/2018 Femara (letrozole), Zoladex (goserelin) Surgery 5/15/2019 Prophylactic mastectomy: Right; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap

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