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Topic: Taken off of Ibrance

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: Feb 3, 2020 03:20PM

Care4MoIVCancer wrote:

Hi all, My mom who has MBC in bone, liver and lungs and is on Ibrance and an aromatase inhibitor was just taken off after two week based on her first blood test. She's incredibly sad about this and reading a ton into it. Is there anyone who has had their dose reduced? Does this mean anything as far as overall impact on the utility of the medication? Thank you in advance!

Caregiver to Mom Stage IV
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Feb 3, 2020 04:34PM - edited Feb 3, 2020 05:02PM by Husband11

The majority of women that start at 125 mg dose get their dose reduced. My wife had her dose reduced twice, to the lowest dose, 75mg, and she had been benefiting from the medicine for a couple of years now. Don't think for an instance that you must have the full strength to benefit. Many women on here are at reduced dose and it holds their cancer at bay.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Feb 3, 2020 04:47PM Care4MoIVCancer wrote:

Thank you Husband11. That is incredibly helpful to know. All the best to you and your wife!

Caregiver to Mom Stage IV
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Feb 3, 2020 05:00PM Spookiesmom wrote:

Very common. This is from the ibrance information packet.

First time IDGgrade 3, stage 3. Second time, found lump myself. That made me stage 4. Dx IDC, Stage IIIA, Grade 3
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Feb 3, 2020 05:01PM - edited Feb 3, 2020 05:02PM by Husband11

Sorry, but I mixed up the highest dosage number. Its 125, then 100, then 75 mg. I was wrong when I posted 150mg. There is no such dose. I corrected my earlier post.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Feb 3, 2020 06:41PM SandiBeach57 wrote:

I was reduced from 125 mg to 100mg in 3 months of starting due to low neutrophil and platelet count.

I have been on Ibrance/ Letrozole since Jan 2017.

I am RARELY sick..just occasional cold.

Wear your jewelry.
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Feb 3, 2020 08:14PM KBL wrote:

I started on 125 mg and immediately got knocked down to 75. I had to stay off for three weeks before my counts were good enough. I have even had times in the 75 mg that I’ve had to take an extra week off. It’s very common to have this happen.

Missed diagnosis from 8/2013 - De Novo ILC - No primary found. Mets to full spine, femurs, skull, and stomach. Dx 5/1/2019, ILC, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Targeted Therapy 6/24/2019 Ibrance (palbociclib) Hormonal Therapy 6/24/2019 Femara (letrozole) Hormonal Therapy 9/20/2021 Faslodex (fulvestrant) Chemotherapy 9/27/2021 Xeloda (capecitabine)
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Feb 3, 2020 08:48PM BLMike wrote:

My wife has had her next cycle delayed a couple times due to low neutrophil levels. Although she started out on 125mg she quickly went to 100mg and recently was dropped down to 75mg for her 8 cycle of Ibrance. There are plenty of patients doing quite well on 100mg or 75mg and some are on a 3 week on and 2 week off schedule to allow their immune systems to recover.

A member to gather information for my wife Dx 2009, DCIS, Stage 0, ER+/PR+, HER2- Dx 2016, IDC, Stage IA, 0/5 nodes, ER+/PR+, HER2- Dx 4/20/2019, IDC, Stage IV, metastasized to lungs, ER+/PR+, HER2- Dx 10/2020, IDC, Stage IV, metastasized to liver, ER+/PR+, HER2- Dx 7/2021, Stage IV, metastasized to brain Targeted Therapy Piqray (alpelisib) Hormonal Therapy Faslodex (fulvestrant) Surgery Lumpectomy; Lymph node removal: Underarm/Axillary Radiation Therapy Breast Hormonal Therapy Femara (letrozole) Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Targeted Therapy Lynparza Chemotherapy Abraxane (albumin-bound or nab-paclitaxel)
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Feb 4, 2020 10:20AM Care4MoIVCancer wrote:

Thank you all for your encouraging words. I knew that some people reduce their dose, but I'm glad to hear that the reduced dosage doesn't necessarily mean that there is an impact on the drug's ability to fight the cancer.

I'm hoping she can be on this treatment for some time. I'm struggling with an overall prognosis estimate based on her mets, it feels so difficult to plan for the future when we just don't know how she'll respond to the drugs.

Caregiver to Mom Stage IV
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Feb 4, 2020 10:32AM - edited Feb 4, 2020 10:32AM by Spookiesmom

That's true for anyone. There are other drugs out there if ibrance isn't for her. Live each day the best she can.

First time IDGgrade 3, stage 3. Second time, found lump myself. That made me stage 4. Dx IDC, Stage IIIA, Grade 3
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Feb 13, 2020 01:28PM Daylightdancer666 wrote:

I got taken off imbrance middle of second xycle not to whire blood cells nut instead sore mouth. She askwd me few months lster id wanted to go back refused so im on zokadex and lethzole last scan showed considerable shrinkage xxd

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