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Topic: Ibrance 125mg capsules

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: Feb 27, 2020 11:56AM

Shraylene wrote:

3 days into ibrance, noticed capsules look 1/3 to 1/2 full. Called Pfizer, they are looking into it, no 9ne there has an answer, does anyone here take this and are your capsules full?

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Mar 2, 2020 01:21PM Shraylene wrote:

Pfizer finally returned my call and yes, the capsule Have the right amount but are not full

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Jun 1, 2020 08:22PM M-and-M37 wrote:

How Are you doing? How are the side effects? I start the same dosage on Friday and I’m nervous. Are you getting the Faslodex as well? I hope all is well for you

Dx 6/21/2018, IDC, Left, Stage IIIC, 13/21 nodes, ER+/PR+, HER2- (FISH) Surgery 8/21/2018 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/20/2018 AC + T (Taxol) Hormonal Therapy Arimidex (anastrozole) Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall
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Jun 2, 2020 01:29PM - edited Jun 2, 2020 01:30PM by Shraylene

Dont be nervous. Piece of cake. I'm on my 4th round and taking it with letrozole. Absolutely NO side effects. Had my petscan after 4 months last week and tumors have shrunk!!! It works! Hope it works the same for you!

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Jun 2, 2020 08:41PM M-and-M37 wrote:

Thank you so much. That really puts my mind at ease. I start on Thursday and when I read that list of side effects it really frightened me. I had a tough time with my chemo. Hoping this will be better. Again thank you.

Dx 6/21/2018, IDC, Left, Stage IIIC, 13/21 nodes, ER+/PR+, HER2- (FISH) Surgery 8/21/2018 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/20/2018 AC + T (Taxol) Hormonal Therapy Arimidex (anastrozole) Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall
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Jun 23, 2020 01:44PM vbishop wrote:

I don't mean to be a Debbie Downer, but it appears that Ibrance quit working for me after two rounds. Great pet results in April, then tumor markers started to go up; CA27-29 now at 90, was at 48 in April, and 69 two weeks ago. Something is going on. It is either a new cancer altogether or the Ibrance quit working. I am hoping for the later, as the former would complicate treatment all the way around.

On a positive note, I have handled all chemo quite well; other than recent tumor markers going up, my WBC and RBC counts have been better than expected. I have yet to get into the "stay away from people" range (of course, with Covid, I am staying away from people anyway).

This is also like comparing apples to oranges. I have ILC, which is a different beast altogether. It goes where it wants and when it wants. To date, I have a spot on my liver and on my T-11. When I was first diagnosed with a recurrence, it was with multiple tumors in lymph nodes in my neck and chest, one of which is partially encasing my carotid artery. Fun, right?


vjbishop.blogspot.com Dx 9/8/2013, LCIS/ILC, Left, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 10/7/2013 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 12/22/2013 Reconstruction (left); Reconstruction (right) Dx 9/2019, ILC, Left, Stage IV, metastasized to liver/other, Grade 2, 0/3 nodes, ER+/PR+, HER2- Dx 9/2019, ILC, Stage IV, metastasized to liver/other, Grade 2, 0/3 nodes Chemotherapy
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Jul 10, 2020 09:05AM zeek_mama wrote:

This is encouraging. I am new to this support forum, and caregiver to my Mom who was diagnosed in May with MBC (she originally had a stage II tumor removed ~10 years ago, followed by chemo, radiation and 5 years of Arimidex) and a clean mammogram in August. It showed up with mets to many internal organs (including lung) and spine. Her oncologist was confident Letrozole and IBRANCE combo would be helpful but she's had SUCH a rough time since May with everything continuing to go downhill, trouble breathing. several visits to emergency room, two hospital admissions. She hasn't been able to eat and without taking in enough her potassium fell to dangerously low levels. Then in one of her hospital visits she broke the head of her femur and had to have a partial hip replacement so now she is also rehabbing from that.

In short, we are really struggling and I SO MUCH want her to feel better and she's so sick. Does anyone struggle with taking the large IBRANCE pills? SHe is about to start her second cycle today and on day 20 of her first cycle she nearly choked to death on the pill. DOes anyone take it with applesauce or something to help? That's how we take smaller pills like Letrozole.

She is exhausted and now she's sort of confused, I hope this is temporary and goes away as her cancer gets under control? Anyone else feel the same?


THANK you for any guidance and wishing everyone good health. Appreciate any advice about which forum to look in as this is my first visit.

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Jul 10, 2020 11:39AM KBL wrote:

zeek_mama, I’m so sorry you’re mom is struggling. My husband takes pills with milk because he struggles to swallow them, so maybe she could do that.

I started on 125 mg and after one month went straight to 75 mg. Maybe that will be an option soon.

I hope she feels better soon.

Missed diagnosis from 8/2013 - De Novo ILC - No primary found. Mets to full spine, femurs, skull, and stomach. Dx 5/1/2019, ILC, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Targeted Therapy 6/24/2019 Ibrance (palbociclib) Hormonal Therapy 6/24/2019 Femara (letrozole) Hormonal Therapy 9/19/2021 Faslodex (fulvestrant) Chemotherapy 9/26/2021 Xeloda (capecitabine)

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