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Topic: if oral CHEMO has failed ...

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: Jul 22, 2020 08:52AM

FaithAndTrust wrote:

my dear friend has just been told that oral CHEMO CAPE has stopped worked and she must now have taxol IV CHEMO.. she is very upset as she thought she would have longer in oral chemos..if the TAXOL gets cancer under control could she go back to oral CHEMO?

Many thanks for any help on this for my friend ❤

Dx 11/2014, ILC, Left, 1cm, Stage IIB, Grade 2, 2/8 nodes, ER+/PR+, HER2- Chemotherapy
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Jul 26, 2020 09:17PM LoriCA wrote:

A chemo drug stops working when the cancer becomes resistant to it. You wouldn't typically immediately go back to the same drug that no longer works. Sometimes it's worthwhile to try it again a few years later because the cancer may have changed/mutated enough that the drug will work again, but that's usually something that's tried when we start running out of options. My MO had me try Taxol a second time only because I had such a good response to it the first time, but it was obvious after two infusions that my cancer was still resistant to it.

Her oncologist should be discussing if she'll be on Taxol until it stops working or if he only intends to keep her on it for a specific period of time. We usually stay on a drug until it stops working, and then move on to the next one. Can't say what might be next for your friend without knowing her ER/PR/HER2 status and what drugs she has already done. There are other oral cancer drugs but we don't know if they are appropriate without more information.

IBC Stage IV de novo - mets throughout skeleton (bones & now bone marrow), liver, dozens of distant nodes, chest wall/pec muscle, skin, tumor in brachial nerves, thyroid, polycythemia from bone marrow involvement Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/25/2017 Taxol (paclitaxel) Targeted Therapy 2/5/2018 Perjeta (pertuzumab) Targeted Therapy 2/5/2018 Herceptin (trastuzumab) Chemotherapy 11/25/2018 Taxol (paclitaxel) Radiation Therapy 1/29/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy Enhertu (fam-trastuzumab deruxtecan-nxki)
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Jul 30, 2020 06:47PM FaithAndTrust wrote:

thanks Lori for taking the time to reply..my friend is happier knowing that you can revisit some drugs so tgat was great to tell her. she started Taxol yesterday and yes told on it until stabilisation or it stops working.

she is IBC too but HER2 neg..

good luck to you Lori and thanks again.

Dx 11/2014, ILC, Left, 1cm, Stage IIB, Grade 2, 2/8 nodes, ER+/PR+, HER2- Chemotherapy

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