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Topic: Efficacy of Pertuzumab to treat metastasis breast cancer.

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: May 17, 2021 12:20AM - edited May 17, 2021 12:21AM by Koushik

Koushik wrote:

All,

I am from India. My mother 59 Years of age was diagnosed with Her2 +ve metastasis breast cancer (metastasis with Lungs alone). she is currently being treated with chemo therapy and targeted therapy drugs(trastuzumab alone).

Here are my questions,

How does Pertuzumab(perjeta) helps to treat metastasis breast cancer? as she was treated with 3 cycles of chemo and targeted therapy(trastuzumab), can we start with pertuzumab from the 4th cycle ?

Also, how long both the pertuzumab and trastuzumab will be advised?, I heard it is going to be 1 year Therapy. However, from posts here people are prescribed with this therapy for more than 5 to 6 years.


Thanks in advance everyone.

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May 17, 2021 07:18AM Olma61 wrote:

Hello and welcome to the community. For metastatic HER2+ positive breast cancer, treatment with Herceptin is “forever” I.e., as long as the patient is tolerating it well OR until the disease becomes resistant.

Adding pertuzamab does have a benefit, the big study that confirmed this is the CLEOPATRA study.

Wish the best for you and your mom. Take care


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/29/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/29/2019 External: Bone
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May 17, 2021 04:19PM moth wrote:

Hi Koushik, welcome to the board & I'm sorry about your mom's diagnosis.

We have lots of info and support here. There is an active lung metastasis thread https://community.breastcancer.org/forum/8/topics/...

If your mother is ER-/PR-/HER2+ then you might want to look at the first post of this thread as it lists the common treatment options https://community.breastcancer.org/forum/8/topics/...


I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone
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May 18, 2021 02:19PM Koushik wrote:

The posts are very much informative.Thanks moth.

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May 18, 2021 02:26PM Koushik wrote:

Curiosity.!!

My mother has gone 3 cycles of chemo and out of them last 2 were with "Herceptin". She tolerated past 3 cycles well, not many Side effects.

We have decided to add Pertuzamab from the next cycle which is due on 05/21. In this scenario can we anticipate any SE's adding due to Pertuzamab now?,That too I am worried that 1st dose is twice the normal ones.. Your experiences pleaseee ..

Thanks much...!!!!

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May 18, 2021 02:32PM Olma61 wrote:

Diarrhea is a common side effect of both Herceptin and Perjeta. My body adjusted after the first few infusions and I no longer have that problem.

If she is tolerating the Herceptin well, chances are the Perjeta will be tolerated well also.

Good luck

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/29/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/29/2019 External: Bone
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May 20, 2021 10:22AM Koushik wrote:

Thank you..!, A sigh of relief.

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