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Topic: Beginning Verzenio

Forum: Stage IV/Metastatic Breast Cancer, Open to All To Contribute —

Topics here are started by members with a Stage IV/Metastatic Breast Cancer diagnosis, but open to all members to contribute to discussions. Please note that there is a separate forum, Stage IV/Metastatic Breast Cancer ONLY, where topics are open only to those members.

Posted on: Nov 30, 2021 12:57PM

sjn wrote:

I have been on Ibrance for 18 months (first drug after stage 4 met diagnosisbut the side effects became severe enough that onc advised a few months off. Now I am to begin Verzenio and am feeling a bit apprehensive based on what I’ve read about it. Any advice, words of wisdom or just encouragement out there? Really could use some right now.

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Nov 30, 2021 05:33PM Lee64 wrote:

Ihave been on Ibrance for almost 24 months, but a nodule in my left upper lung has been growing and ONC said to stop Ibrance and he put me on Verzenio. I don't have the drug yet and know nothing about it except its known to cause diarrhea. I haven't looked for a Verzenio thread on BCO yet. Good luck!

Dx 11/5/2010, IDC, 3cm, Stage IIB, 2/6 nodes, ER+/PR+, HER2-
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Nov 30, 2021 07:48PM prairiesea wrote:

sorry to hear about progression in lung, Lee64. I have been on Verzenio for 4 months. (after 3 cycles of Ibrance on progressively lower doses all of which tanked my anc) I struggled with diarrhea at the beginning. I have had good luck with Meta Mucil. I take capsules (because they don't have sugar or aspartame). I've found 4-5 twice a day keeps things in check....sometimes heads me toward constipation in which case I back off. Still on highest dose and haven't had diarrhea in about 6 weeks. Sorry to hear about progression. Also there is good advice on the Verzenio/abemaciclib thread. all best to both.

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Dec 3, 2021 12:03PM Tanya_Djamila wrote:

Another MBC participant let me know that there is a study going on for MBC patients taking Kisqali, Ibrance or verzinio. They are paying $175 for completion of an online survey. they will also pay your spouse/partner. If anyone is interested you can contact them directly by email or phone.

Jane is

Devi is

And their phone numbers are;

(212) 779-0033 or (212) 401-7902

Tanya Dx 8/19/2003, ILC, Right, 6cm+, Stage IIIA, metastasized to bone/other, 28/28 nodes, ER+, HER2+ (IHC) Dx 4/19/2017, Stage IV, metastasized to bone/other, 0/0 nodes, ER+, HER2+ (IHC) Hormonal Therapy 6/19/2017 Faslodex (fulvestrant)
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Dec 3, 2021 02:36PM star2017 wrote:

My symptoms hit at about a week in. At 150mg of Verzenio, I had diarrhea several times a day. Just one dose of imodium fixed the problem, but my MO didn't want me taking the Imodium daily, so she reduced me to 100mg of Verzenio. Since then I've had no obvious issues.

Dx@37, pregnant, BRCA2+ Dx 9/2017, DCIS/IDC, Right, 6cm+, Stage IIIA, Grade 3, 4/8 nodes, ER+/PR+, HER2- Surgery 10/17/2017 Mastectomy: Right; Reconstruction (right): Tissue expander placement Chemotherapy 11/29/2017 AC + T (Taxol) Surgery 4/18/2018 Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Silicone implant Radiation Therapy 5/21/2018 Whole-breast: Breast, Lymph nodes Surgery 10/24/2018 Prophylactic ovary removal; Reconstruction (left): Silicone implant Hormonal Therapy 6/19/2019 Arimidex (anastrozole) Dx 5/2021, IDC, Right, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Targeted Therapy 8/4/2021 Verzenio Targeted Therapy Lynparza Radiation Therapy External: Bone Hormonal Therapy Faslodex (fulvestrant)
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Dec 3, 2021 02:53PM sjn wrote:

this is really helpful to know I am at day 3 of the same dosage and have had a few twinges in my stomach but nothing horrible. It sounds as though symptoms worsen as the meds accumulate in the system. Thanks for your respons

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Dec 3, 2021 02:57PM sjn wrote:

several people have mentioned using Meta Mucil. Thanks for the suggestion. All are so very appreciate

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Dec 24, 2021 09:36PM Bonnie7 wrote:

Me too just started a few days ago! Pse let me know how you are doing! X Private e-mail.

Also for anyone else who wld like to exchange notes!

Merry Xmas all! 😘🧡

Dx 2002, DCIS, Right, Stage 0, Grade 1, ER+/PR+, HER2- Dx 2005, IDC, Right, 2cm, Stage IIIA, Grade 3, ER+/PR+, HER2- Dx 2016, IDC, Right, 2cm, Stage IIIB, Grade 3, ER+/PR+, HER2- Surgery Mastectomy Hormonal Therapy Aromasin (exemestane), Femara (letrozole) Surgery Lumpectomy Radiation Therapy Hormonal Therapy Chemotherapy Surgery Lymph node removal Hormonal Therapy Aromasin (exemestane) Surgery Reconstruction (right): Latissimus dorsi flap Surgery

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