Topic: Vaccine booster

Forum: All things COVID-19 or coronavirus — A place to discuss the impact of COVID-19 (Coronavirus) on you and the ones you love.

Posted on: Aug 10, 2021 04:07PM

Posted on: Aug 10, 2021 04:07PM

finallyoverit wrote:

Hi everyone,

I saw my MO yesterday for a normal, check-in visit and to get results of a recent scan (all stable! 😁). I asked him if I was offered a booster vaccine (received the Pfizer vaccine many months ago and had no ill effects) should I take it. He said yes, even though I’m not considered immunocompromised, he said it wouldn’t be a bad thing to take it.

Just throwing it out there for anyone that might be wondering the same thing. This is just my MOs take on it, but I will say he trained at MD Anderson and teaches the fellows at John’s Hopkins. The 3rd or booster shot isn’t a “thing” yet, but I wanted to get his opinion in the event that I’m offered it. I was really on the fence. I don’t have any strong feeling about not taking it, but wanted to make sure that it would be something that would benefit me before accepting it.


Take care, all!


Dx 10/2011, IDC, Stage IIA, 0/4 nodes, ER+/PR+, HER2- Dx 5/2017, Stage IV, metastasized to bone
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Aug 31, 2021 07:40PM - edited Aug 31, 2021 08:28PM by olma61

I was really confused after several different emails I received and then the advice at the cancer center on Friday. I mentioned this in the RANT thread. This morning I received another email from the cancer center. I sense that I wasn't the only confused patient because the email contained a detailed FAQ and a request NOT to call the cancer center with questions about boosters.

As to confusing messaging, I note that my sister, not immune compromised or a cancer pt, also received an email from her vax site that seemed to say she could come on in and get a booster. Her and her husband did not do it because they didn't want to take up a space from someone who needed it more.

Basically the latest. email said, if you are not moderately to severely immuno-compromised you are not eligible for a booster at this time. (That same verbiage is now on the State of NJ website)

They specifically said if you received only hormone therapy or targeted therapy for your cancer or are only on observation - you are not automatically considered immune compromised.

I will provide a screenshot or the text of the latest email I got when I get to my other device. I think in my own case, regardless of what the substitute onc told me on Friday, I am not eligible. I am not in a hurry for the booster, my second pfizer shot was in May. I also hope that if I wait a few months there will be an updated booster that addresses the current mutations as opposed to rushing to get a third shot of the very same vax.

Here is the relevant text - just providing this for information only. Not advising anyone

FAQs about the COVID-19 Vaccine Booster Dose for Cancer Patients1. Why is a third vaccine being recommended?

Some patients, especially patients with compromised immune systems, do not have a strong response after receiving vaccines. In these cases, public health officials recommend an additional dose of the vaccine. In the case of COVID-19, immunocompromised patients who received mRNA vaccine (Moderna or Pfizer) should receive a third dose of mRNA vaccine after completing the initial vaccine series.

2. Who is eligible for a 3rd dose of the vaccine?

Patients with liquid tumors or blood cancer who meet the following criteria:

• Patients being treated for blood cancers currently or within the past 12 months.

• Patients who were within 2 years after treatment with B-cell depleting drugs (i.e. Rituxan [rituximab] or Gazyva [obinutuzumab]) at the time of their initial vaccination.

• Patients being treated with IVIG for recurring infections.

• Recipients of CART-T-cell, autologous or allogeneic hematopoietic stem cell transplant (within 2 years of transplantation or taking immunosuppressive therapy).

Patients with solid tumor cancers who meet the following criteria:

• Patients treated with chemotherapy or immunotherapy currently or within the past 6 months.

Patients with other reasons for a compromised immune system:

• Receipt of solid organ transplant and taking immunosuppressive therapy.

• Moderate or sever primary immunodeficiency

• Advances or untreated HIV infection

Patients with autoimmune disease and on active treatment with a high-dose of corticosteroids (i.e. =20mg of prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs and cancer chemotherapeutic agents classified as severely immunosuppressive or immunomodulatory.

3. Which cancer patients are not eligible for a third dose at this time?

Patients with solid tumors are not considered immunocompromised if their cancer has been treated with hormone therapy, targeted therapy, surgery, radiation, or are under observation only.


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+, IHC Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External Local Metastases 5/30/2019 Radiation therapy: Bone
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Aug 31, 2021 07:49PM - edited Aug 31, 2021 07:49PM by alwaysmec

Nancy, this article from a few days ago suggests that J & J is going to or have recently submitted for approval of a booster. It sounds like it's in the works, but won't be available for a while.

https://www.npr.org/sections/coronavirus-live-updates/2021/08/25/1030909283/johnson-and-johnson-covid-vaccine-booster-six-months

Chemotherapy 4/29/2021 Other Targeted Therapy 4/29/2021 Kanjinti Targeted Therapy 4/29/2021 Perjeta (pertuzumab) Targeted Therapy 9/2/2021 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.phesgo Targeted Therapy 9/20/2021 Herceptin (hylecta) Surgery 9/23/2021 Lumpectomy (Left); Lymph node removal (Left): Sentinel Chemotherapy 11/12/2021 Other Targeted Therapy 5/3/2022 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.phesgo Dx IDC/DCIS, Left, 1cm, Stage IIA, Grade 2, 1/4 nodes, ER-/PR-, HER2+, ISH, IHC
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Aug 31, 2021 08:15PM Nancy2581 wrote:

Thank you for posting that AlwaysMeC


2.8 cm tumor with LVI Dx 6/11/2014, IDC, Right, 2cm, Stage IIB, Grade 1, 1/3 nodes, ER+/PR+, HER2-, Surgery 6/24/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 7/22/2014 AC + T (Taxol) Hormonal Therapy 1/28/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 1/29/2015 Whole breast: Breast, Lymph nodes Hormonal Therapy 12/16/2017 Femara (letrozole) Hormonal Therapy Aromasin (exemestane)
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Aug 31, 2021 11:23PM serenitystat wrote:

Olma - I'm hoping a half dose of Moderna/Spikevax will be available as a booster. It's been tested against Delta. In the meantime even if antibody levels drop, we're still protected by the memory cells. Think this is why the rates of hospitalization and death remain low for vaccinated people.



BCO leaked our private data. 🤦🏻‍♀️🤷🏻‍♀️ . . . . . "Do not overlook the little joys!" (Hesse, 1905) 🐶Dx.11/2015.IDC.L.IIIC.10/11nodes.++- ☕️12/2015.L.Mast 🛀2/2016.4AC.12Taxol.fasted 🖼9/2016.Rads.Nodes.ChestWall.15+4boosts 🥐10/2016.Tamox(2.5y) 🌲4/2019.Exemestane 🎭12/2019.Ibrance/Xgeva 🕊
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Sep 2, 2021 07:57PM snow-drop wrote:

I had a chat with my nurse, MO recommended 8 months gap between a booster and the second shot. Department of health in our state estimated 800,000 people eligible to get additional shot, so I don’t take someone’s turn who is in need now. I condouble-masking until my turn, plus vaccination rate in my city is %77 fully vaccinated of eligible population (the rate is greater, those received at least one dose). it is good to be safe and supported.

new terminology 🤯

What is the difference between an additional dose and a booster dose?

An "additional dose" of a COVID-19 vaccine is administered to individuals with weakened immune systems who have not responded fully to initial doses.

A "booster" dose is administered when the response to initial vaccination might have decreased to levels that increase vulnerability.

De Novo stage IV Dx 9/2019, IDC, Left, 4cm, Stage IV, metastasized to bone/other, Grade 2, ER+/PR+, HER2-, IHC Radiation Therapy External Hormonal Therapy Femara (letrozole) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Zoladex (goserelin) Local Metastases Radiation therapy: Bone
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Sep 2, 2021 08:19PM Chowdog wrote:

Snow Drop,

So, immunocompromised population needs 3 doses (the same vaccine, the same dosage as the original) instead of 2 doses like general population. The booster, FDA&CDC are talking about, is a booster for general population when their immune response wanes.

The booster may or may not be the same dosage. so for Moderna, it looks like the booster will be 50ug instead of 100ug for the original vaccine.

https://investors.modernatx.com/news-releases/news...

For pfizer, it still looks like it will be the same dosage as the original vaccine.


Dx 6/2007, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 7/2/2007 Mastectomy: Left, Right Chemotherapy 8/15/2007 AC + T (Taxol) Hormonal Therapy 1/10/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Dx 2/12/2018, IDC, Stage IV, metastasized to brain/bone/lungs, ER+/PR+, HER2- Hormonal Therapy 2/12/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 3/19/2018 External: Brain Targeted Therapy 4/9/2018 Ibrance (palbociclib) Hormonal Therapy 4/9/2018 Femara (letrozole), Zoladex (goserelin)
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Sep 4, 2021 08:17PM racheldog wrote:

Chowdog, I have not read or researched any data that the additional dose or "booster" is going to be reduced. All the recent articles , very recent, stated that the boosters are basically the same strength.

This is of particular concern to me as on dose #2 (after starting one dose of Kadcyla back in the beginning of the year) I spiked a very high temp in the middle of the night. Fever is a known SE of the vaccines but this elevation sent me to the ER for a long stay until they determined all was ok to go home. That concerns me now about getting the 3rd booster in the middle of Herceptin only infusions. Not up for another ER evaluation, especially now when ERs are full of covid patients.

Makes me think I should complete infusions and then consider the 3rd vaccine.

Dx 9/2020, IDC, Left, <1cm, Stage IA, Grade 3, ER+/PR+, HER2+ Radiation Therapy 6/1/2021 Whole breast Chemotherapy Other Surgery Lumpectomy; Lumpectomy (Left) Chemotherapy Chemotherapy Other
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Sep 4, 2021 08:42PM - edited Sep 4, 2021 08:52PM by Chowdog

Rachel,

the reduced (half dose) booster is only being studied by Moderna. Also this is for general population, not for immunocompromised. I read on twitter/WSJ that FDA supposedly asked Moderna for more data with regarding the booster dosage like why half vs full.

For immunocompromised, you will get 3 shots instead of 2, and it will be the same vaccine & dosage as the first 2 doses.

You should talk to your MO about the timing of your 3rd shot. I also got fever as part of SE after the 2nd dose but not high enough to go to ER.

I can't figure out how to copy&paste the cached version of the WSJ article, so just copied & pasted the text instead.

"Exclusive: FDA Weighing Dose of Moderna Covid-19 Booster

By Felicia Schwartz and Stephanie Armour

A patient receiving a dose of Moderna's Covid-19 vaccine at a hospital in Odessa, Texas, last week.ELI HARTMAN/ODESSA AMERICAN/ASSOCIATED PRESS

The Food and Drug Administration is considering whether to authorize a lower dose of Moderna Inc.'s Covid-19 vaccine for boosters than the dose given in the first two shots, people familiar with the deliberations said.

Moderna said Wednesday it is asking the FDA to authorize a 50 microgram dose, half the dosage of the first two shots. Some in the government are leaning toward authorizing the 100 microgram dose, the people said, because of concerns a lower-dose booster might not offer a durable enough boost to counter fast-changing variants of Covid-19.

No final decision has been made, the people said, as the FDA is still reviewing data from studies that tested boosters using the different doses. People who have seen the data said both doses produce a strong immune response.

Complicating the decision is the fact that the FDA has limited comparative data on which to base their choice, one person familiar with the discussions said.

The continuing deliberations are a reason the agency hasn't yet authorized boosters, though the people expect a decision soon.

Read the full story."


Dx 6/2007, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 7/2/2007 Mastectomy: Left, Right Chemotherapy 8/15/2007 AC + T (Taxol) Hormonal Therapy 1/10/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Dx 2/12/2018, IDC, Stage IV, metastasized to brain/bone/lungs, ER+/PR+, HER2- Hormonal Therapy 2/12/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Radiation Therapy 3/19/2018 External: Brain Targeted Therapy 4/9/2018 Ibrance (palbociclib) Hormonal Therapy 4/9/2018 Femara (letrozole), Zoladex (goserelin)
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Sep 7, 2021 01:38PM racheldog wrote:

Not sure what I will do about the booster or the timing. I believe in the 3rd dose, for now, but there are little updates about how immunocompromised patients are tolerating this third dose. Especially with Moderna which had more SE on the 2nd dose. I secured an appointment for a booster in between my Herceptin infusions. I certainly do not want a high fever again or bad side effects so I very well may finish out my Herceptin and do the booster after.

That timing would be beyond my 8 month time frame. Herceptin has been "ok" but don't feel super on that either and it would be hard to differentiate what was causing chills or fever? I do not see articles with a lot of reviews (yet) on how well the 3rd dose is being tolerated by those with cancer currently in treatment. And experts seem to be chiming in and not 100% in agreement that the booster is needed right now. Only the CDC pushing this.

Dx 9/2020, IDC, Left, <1cm, Stage IA, Grade 3, ER+/PR+, HER2+ Radiation Therapy 6/1/2021 Whole breast Chemotherapy Other Surgery Lumpectomy; Lumpectomy (Left) Chemotherapy Chemotherapy Other
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Sep 13, 2021 01:37PM - edited Sep 13, 2021 01:55PM by reckless

https://apple.news/Ahq7YFCp3Rnm3IEB6zJW-OQ

This does not bode well for the booster shot approval for the general population by FDA on September 17. Thoughts? I am worried because I am not considered immunocompromised, and hence not eligible for a booster shot currently. Was really hoping that I will be able to get it after September 20!

💉💉💉 Dx 3/4/2016, IDC, Right, 2cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 4/19/2016 Mastectomy; Mastectomy (Right); Prophylactic mastectomy; Prophylactic mastectomy (Left); Reconstruction (Left): Tissue Expander; Reconstruction (Right): Tissue Expander Hormonal Therapy 6/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 8/11/2016 Reconstruction (Left): Silicone implant; Reconstruction (Right): Silicone implant Surgery 11/14/2017 Hormonal Therapy 6/20/2018 Arimidex (anastrozole)

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