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Topic: Pregnancy Associated BC - incl. lactation and post-partum 5 yrs+

Forum: Young With Breast Cancer —

Connect with those under 40 who have been diagnosed.

Posted on: Sep 12, 2015 11:51AM - edited Sep 12, 2015 01:51PM by agness

agness wrote:

I was a slightly older mom but I was diagnosed while breastfeeding so I have been collecting research and articles as I have tried to address my disease from this under-researched area. Please post useful links and articles that can help us build a body of evidence that we can improve our outcomes.

Tagging this with its abbreviations: PABC, GABC


"Pregnancy at a relatively young age reduces the risk of breast cancer over the long term, but epidemiological studies have found that women are at an increased risk for breast cancer during pregnancy and for up to 10 years after giving birth, said Debra Tonetti, associate professor of pharmacology and lead researcher on the study. These pregnancy-associated breast cancers also carry an unusually high risk of spreading to nearby organs and for lethality as compared to breast cancers in women who have never been pregnant, she said."

Clues to Pregnancy-Associated Breast Cancer Found

http://chicago.medicine.uic.edu/cms/One.aspx?pageId=10491764

Researchers study breast cancers after pregnancy

http://www.usatoday.com/story/news/nation/2012/10/02/breast-cancer-after-pregnancy/1601129/

Breastfeeding and Breast Cancer

http://www.medelabreastfeedingus.com/tips-and-solutions/37/breastfeeding-and-breast-cancer

Do Docs Miss Breast Cancer Warning Signs in Breastfeeding Mothers?

http://www.bestforbabes.org/do-docs-miss-breast-cancer-warning-signs-in-breastfeeding-mothers/

Breast Cancer Diagnosis While Breastfeeding: When Two Worlds Collide

http://onlinelibrary.wiley.com/doi/10.1111/j.1552-6909.2012.01363_1.x/full

Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation

http://breast-cancer-research.com/content/16/1/R2

Breast Cancer, Because Reduced Risk Does Not Mean No Risk

http://theleakyboob.com/2011/10/breast-cancer-because-reduced-risk-does-not-mean-no-risk/

Diagnosing and Managing Breast Disease During Pregnancy and Lactation

http://www.medscape.com/viewarticle/719249_5

Gestational Breast Cancer Epidimiology and Diagnosis

http://www.uptodate.com/contents/gestational-breast-cancer-epidemiology-and-diagnosis

HER2+/HR-. TCHP 3/14, PCR 8/14. Proton therapy. Mets: Brain tumor to cerebellum (5 cm) 7/2015. SRS 9/15. Leptomeningeal (LM) dx 11/2015, Ommaya Reservoir/IT Herceptin 12/15. Partial brain rads 1/2016. More LM & new chemo 9/16. Stable scan 12/16
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Sep 14, 2015 09:04AM agness wrote:

I read about a woman who persisted in being treated for parathyroid issues and her fibroid tumor and a host of other health issues went away. It turns out that elevated parathyroid hormone (PTH) increases risk of developing breast cancer and it tends to also go up during pregnancy and lactation. Low magnesium increases parathyroid issues and it was something I tested low to and also something that naturopathic oncologists are taugh to check in new cancer patients as magnesium tends to be low.

Other Causes of Parathyroidism

https://hypoparathyroidism.com/what-causes-hypopar...


Breast Cancer Associated with Primary Hyperparathyroidism

Breast cancer primary hyperparathyroidism link

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307215...!po=2.41935


Hypercalcemia in Pregnancy and Lactation Associated with Parathyroid Hormone-Related Protein

http://www.nejm.org/doi/full/10.1056/NEJM199303043...


HER2+/HR-. TCHP 3/14, PCR 8/14. Proton therapy. Mets: Brain tumor to cerebellum (5 cm) 7/2015. SRS 9/15. Leptomeningeal (LM) dx 11/2015, Ommaya Reservoir/IT Herceptin 12/15. Partial brain rads 1/2016. More LM & new chemo 9/16. Stable scan 12/16
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Sep 15, 2015 04:55AM agness wrote:

Expression of the Pluripotency Transcription Factor OCT4 in the Normal and Aberrant Mammary Gland

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622876/

"Breast cancers with lactating features, some of which are associated with pregnancy and lactation, are often poorly differentiated, lack estrogen receptor, progesterone receptor, and HER2 expression and have high mortality. Very little is known about the molecular mechanisms that drive uncontrolled cell proliferation in these tumors and confer lactating features. We have recently reported expression of OCT4 and associated embryonic stem cell self-renewal genes in the normal lactating breast and breastmilk stem cells (hBSCs)"


HER2+/HR-. TCHP 3/14, PCR 8/14. Proton therapy. Mets: Brain tumor to cerebellum (5 cm) 7/2015. SRS 9/15. Leptomeningeal (LM) dx 11/2015, Ommaya Reservoir/IT Herceptin 12/15. Partial brain rads 1/2016. More LM & new chemo 9/16. Stable scan 12/16
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Sep 15, 2015 04:59AM - edited Sep 15, 2015 05:01AM by agness

Mentions nestin in lactation, also mentioned for breast cancer

Breastfeeding and Human Lactation (book)

https://books.google.com/books?id=lDb3BQAAQBAJ&pg=...

HER2+/HR-. TCHP 3/14, PCR 8/14. Proton therapy. Mets: Brain tumor to cerebellum (5 cm) 7/2015. SRS 9/15. Leptomeningeal (LM) dx 11/2015, Ommaya Reservoir/IT Herceptin 12/15. Partial brain rads 1/2016. More LM & new chemo 9/16. Stable scan 12/16
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Sep 15, 2015 05:03AM - edited Sep 15, 2015 05:04AM by agness

Pregnancy and Breast Cancer: When They Collide

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC269378...!po=0.757576

Includes lactation

HER2+/HR-. TCHP 3/14, PCR 8/14. Proton therapy. Mets: Brain tumor to cerebellum (5 cm) 7/2015. SRS 9/15. Leptomeningeal (LM) dx 11/2015, Ommaya Reservoir/IT Herceptin 12/15. Partial brain rads 1/2016. More LM & new chemo 9/16. Stable scan 12/16
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Dec 16, 2015 03:34PM - edited Jan 28, 2016 05:09PM by jks123

This Post was deleted by jks123.
Dx 11/2014, DCIS/IDC, Left, 4cm, Stage IIB, Grade 3, 0/2 nodes, ER-/PR-, HER2+ (FISH) Chemotherapy 11/22/2014 Carboplatin (Paraplatin), Taxol (paclitaxel) Targeted Therapy 12/9/2014 Herceptin (trastuzumab) Radiation Therapy 8/22/2015 Whole-breast: Breast, Lymph nodes, Chest wall Surgery Mastectomy: Left; Reconstruction (left): Silicone implant, Tissue expander placement
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Feb 18, 2016 07:49AM mathilde wrote:

I am glad I found this thread, as I also stumbled across research on postpartum BC and have been following the growing body of research. Virginia Borges from University of Colorado does a lot of research on PABC, and she presented at the last ASCO on postpartum breast cancer. Her slides are available for purchase on the ASCO slide library. It updates her previously published research which you have cited above. I read somewhere that they have expanded the size of the group they are following, and unfortunately, the picture is not getting any less scary. I just wish more doctors knew about this and could advise on how this impacts clinical treatment decisions - mine had never heard of it and blew it off as bunk, but when I use google scholar to research the link between reproductive factors and breast cancer, there have been articles linking pregnancy and breastfeeding to breast cancer for years.

I also saw Vogue published an article on this in November 2015 - seems sad when vogue magazine is more to date than my oncologist!

Not sure if you had already included this one:

http://www.cancernetwork.com/oncology-journal/mana... Management of the Patient with Postpartum Breast Cancer

http://www.ncbi.nlm.nih.gov/pubmed/23430224 Post Partum diagnosis demonstrates a high risk of metastasis and merits an expanded definition of pregnancy associated breast cancer


Some of the U Colarado research on postpartum breast cancer:

http://mct.aacrjournals.org/content/14/12_Suppleme...

Lymphangiogenesis drives breast tumor cell spread in postpartum women and in models of postpartum breast cancer


http://onlinelibrary.wiley.com/doi/10.1002/ijc.291... Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression


https://theoncologist.alphamedpress.org/content/20...


Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women
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Mar 20, 2016 09:45PM cajunqueen15 wrote:

thank you so much for this information. I've been looking for the numbers. I was 1 year pp at dx.


35 @ dx. BRCA2. Disciple, wife, mother of twins (6) & son (4), attorney. e3 trial (complete). Blue/MammaPrint, High-risk Luminal B. Prolia (start 6/16). Dx 7/22/2015, DCIS, Left, <1cm, Stage 0, Grade 3, ER+/PR+, HER2- Dx 8/28/2015, IDC, Left, 1cm, Stage IIA, Grade 3, 2/11 nodes, ER+/PR+, HER2- Surgery 8/28/2015 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Silicone implant Surgery 4/12/2016 Prophylactic ovary removal Hormonal Therapy 4/19/2016 Arimidex (anastrozole) Surgery 8/1/2017 Reconstruction (left): Silicone implant Chemotherapy AC + T (Taxol) Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall

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