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Topic: postpartum elevated CA2729 levels ???

Forum: Young With Breast Cancer —

Connect with those under 40 who have been diagnosed.

Posted on: Oct 29, 2015 11:03AM

christina0001 wrote:

Has anyone read anything or experienced elevated CA2729 levels postpartum? I was diagnosed with breast cancer a few years ago, and four weeks ago I gave birth to my first baby. I'm so happy - I didn't think I'd get to have a child after being diagnosed and treated! Anyway, I had my biannual CA2729 level done this week and I went from 30 to 51. My oncologist is sending me to have a mammogram (I was due anyway for one, but I was putting it off - I wasn't keen on having a mammogram done while my one breast is full of milk). I am wondering how worried I should be; I wonder if the postpartum hormones and/or the breastfeeding hormones could have raised the level. It's only been in the 50s once before, when I first started chemo.

Surgery 1/10/2012 Lumpectomy: Right Dx 1/16/2012, IDC, 2cm, Stage IIA, Grade 3, 0/7 nodes, ER+/PR+, HER2+ Surgery 2/9/2012 Lymph node removal: Right, Sentinel Targeted Therapy 2/12/2012 Herceptin (trastuzumab) Chemotherapy 2/12/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/9/2012 Mastectomy: Right Hormonal Therapy 8/23/2012 Radiation Therapy 9/30/2012 Breast Surgery 7/29/2013 Reconstruction (right): DIEP flap
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Oct 29, 2015 03:00PM MelissaDallas wrote:

This says that pregnancy and lactation are non-malignant reasons for elevation:

https://www.questdiagnostics.com/testcenter/testgu...


LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor.
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Oct 30, 2015 04:39PM christina0001 wrote:

Thank you! That is so reassuring!!! Crossing my fingers that this is the reason.

Surgery 1/10/2012 Lumpectomy: Right Dx 1/16/2012, IDC, 2cm, Stage IIA, Grade 3, 0/7 nodes, ER+/PR+, HER2+ Surgery 2/9/2012 Lymph node removal: Right, Sentinel Targeted Therapy 2/12/2012 Herceptin (trastuzumab) Chemotherapy 2/12/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/9/2012 Mastectomy: Right Hormonal Therapy 8/23/2012 Radiation Therapy 9/30/2012 Breast Surgery 7/29/2013 Reconstruction (right): DIEP flap
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Oct 30, 2015 05:29PM MelissaDallas wrote:

I'll cross mine for you too

LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor.
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Nov 2, 2015 07:08AM floaton wrote:

Christina, hi and hope all is well! I had my first mammogram when I was diagnosed while breastfeeding my 6 month old. They couldn't see anything with the mammogram due to all the milk / breastfeeding changes, but did do an ultrasound and later an MRI which could see the tumor. Just thought I'd give you a heads up because I know it was super stressful for me that when I showed up for my mammogram and told them I was breastfeeding it took a while for them to sort themselves out and do the testsbecause no one really knew what to do because it happens so infrequently.

One day you're waiting for the sky to fall; the next you're dazzled by the beauty of it all - Bruce Cockburn Dx 9/2013, IDC, 2cm, Stage IIA, Grade 3, 0/8 nodes, ER+/PR+, HER2- Surgery 9/15/2013 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Chemotherapy 10/15/2013 AC + T (Taxol) Hormonal Therapy 2/14/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 2, 2015 12:13PM christina0001 wrote:

Thank you, Melissa. :) Floaton, we have sort of similar diagnoses and treatment histories. I wish there were more data on pregnancy / postpartum + breast cancer. I have a mammogram and ultrasound scheduled for tomorrow, and I'll see my oncologist on Thursday. I've already started weaning my baby. It makes me sad to do it but if not breastfeeding will help figure out what is going on, then that's just how it's got to be.

Surgery 1/10/2012 Lumpectomy: Right Dx 1/16/2012, IDC, 2cm, Stage IIA, Grade 3, 0/7 nodes, ER+/PR+, HER2+ Surgery 2/9/2012 Lymph node removal: Right, Sentinel Targeted Therapy 2/12/2012 Herceptin (trastuzumab) Chemotherapy 2/12/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/9/2012 Mastectomy: Right Hormonal Therapy 8/23/2012 Radiation Therapy 9/30/2012 Breast Surgery 7/29/2013 Reconstruction (right): DIEP flap
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Nov 3, 2015 07:54AM - edited Nov 3, 2015 07:55AM by floaton

Christina, I'm so sorry that you're going through this - weaning was seriously one of the hardest parts of all of this for me. From my experience, MRI and ultrasound showed my mass just fine without weaning first (I didn't have time I was so surprised!). I even successfully got an ultrasound guided biopsy when I was still actively breastfeeding. I think the only test that was affected was the mammo, which isn't awesome premenopausally anyway. Best wishes with your tests today!!!


Edited to add - it would really be nice if there was more data out there for us, it makes it hard to make decisions in a vacuum

One day you're waiting for the sky to fall; the next you're dazzled by the beauty of it all - Bruce Cockburn Dx 9/2013, IDC, 2cm, Stage IIA, Grade 3, 0/8 nodes, ER+/PR+, HER2- Surgery 9/15/2013 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Chemotherapy 10/15/2013 AC + T (Taxol) Hormonal Therapy 2/14/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 8, 2015 12:40PM christina0001 wrote:

They ended up skipping the mammogram and just doing an ultrasound, which showed no changes. My oncologist is going to have us wait 6 weeks since I've fully weaned baby off of the breast, and then we will redo the CA27.29. Hopefully the level will have gone down. If not, we will do a PET scan. I'm terrified that I have mets somewhere... it would be the absolute worst news possible to get after having a baby. My little guy needs his momma. I really really hope this level goes down, and was just elevated from being postpartum and nursing. We had been talking about trying for a second baby but now we are totally against it, and I'll be restarting tamoxifen soon. Thanks again for the support.

Surgery 1/10/2012 Lumpectomy: Right Dx 1/16/2012, IDC, 2cm, Stage IIA, Grade 3, 0/7 nodes, ER+/PR+, HER2+ Surgery 2/9/2012 Lymph node removal: Right, Sentinel Targeted Therapy 2/12/2012 Herceptin (trastuzumab) Chemotherapy 2/12/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/9/2012 Mastectomy: Right Hormonal Therapy 8/23/2012 Radiation Therapy 9/30/2012 Breast Surgery 7/29/2013 Reconstruction (right): DIEP flap
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Nov 8, 2015 10:20PM floaton wrote:

Christina, that's good news on the ultrasound! I'm keeping my fingers and toes crossed for you that it was all just lactation-related. Hang in there. 6 weeks is a long time, so be kind to yourself, andI'm sure your little guy will help keep you busy :)!


One day you're waiting for the sky to fall; the next you're dazzled by the beauty of it all - Bruce Cockburn Dx 9/2013, IDC, 2cm, Stage IIA, Grade 3, 0/8 nodes, ER+/PR+, HER2- Surgery 9/15/2013 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Chemotherapy 10/15/2013 AC + T (Taxol) Hormonal Therapy 2/14/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 10, 2016 10:28AM christina0001 wrote:

Just in case anyone goes through something similar... we retested my CA2729 3 months post-partum, and about 8 weeks after stopping breastfeeding. The results were just above normal range, and lower than the elevated level I had 4 weeks post-partum and while breastfeeding. We rechecked the CA2729 again 4-5 months postpartum, at which point I was (am) pregnant again (hooray!) and we were thrilled that the CA2729 had finally dropped into the normal range. So at least in my situation, it looks like late pregnancy hormones and/or breastfeeding gave me a temporary high level.

Surgery 1/10/2012 Lumpectomy: Right Dx 1/16/2012, IDC, 2cm, Stage IIA, Grade 3, 0/7 nodes, ER+/PR+, HER2+ Surgery 2/9/2012 Lymph node removal: Right, Sentinel Targeted Therapy 2/12/2012 Herceptin (trastuzumab) Chemotherapy 2/12/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 8/9/2012 Mastectomy: Right Hormonal Therapy 8/23/2012 Radiation Therapy 9/30/2012 Breast Surgery 7/29/2013 Reconstruction (right): DIEP flap

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