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Topic: Meningioma and breast cancer

Forum: High Risk for Breast Cancer — Due to family history, genetics, or other factors.

Posted on: Sep 21, 2014 03:44AM

kazamodia wrote:

Hello everyone

my mom had a spinal meningioma which was surgically dissected . While searching on the internet I found out that there is a possible relation between meningioma and breast cancer . My mom had had her last mammogram done 2 and half years ago due to finding a lump which was a simple cyst . I told the neurosurgeon about that risk and he was like just don't put it in mind and I actually don't like this and can't just wait and see the disaster happening . There is no family history of breast cancer , not even a family history of any type of cancer " no one had cancer in the family yet" Happy

I want to know what should we do to minimize the risk or is this risk too high to care about ? We are very anxious and concerned these days about this issue , what should we do ??

Btw my mom had a hysterectomy with one ovary removed due to endometrial hyperplasia six years ago . The doctor told my mom that time that her estrogen was way too high in her body . She never did estrogen test again .

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Sep 21, 2014 04:02AM MelissaDallas wrote:

I'm reading that meningiomas are more common in women that have had breast cancer, not the other way around.

LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor.
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Sep 23, 2014 01:49PM kazamodia wrote:

well I read the risk can be before or after

does any one else have any idea ??

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Sep 23, 2014 03:25PM leaf wrote:

Metastasis of breast carcinoma to meningioma is a rare phenomenon with relatively few reports in the literature, although it is the most common type of carcinoma-to-meningioma metastasis...Furthermore, as both of these neoplasms often co-occur in women with breast cancer, clinicians should be vigilant of the potential for intrameningioma metastasis when neurological involvement becomes apparent in late-stage disease.

In total, 33 patients with meningioma were identified from a study population of 12,330, with a 10-year cumulative incidence of meningioma of 0.37%. We did not find a significantly increased risk of meningioma among patients with breast cancer or an association between the hormonal receptor status and the risk of meningioma (P = 0.65).


Our results do not support a role of breast cancer or endocrine treatments in meningioma development.

Using the US SEER 18 registry (2004 to 2009), clinicopathologic and demographic characteristics from cohorts of women with only BC (n=279,821) or meningioma (n=19,570) diagnoses were compared with 412 women with both diagnoses (BC-meningioma)...

Women with BC and meningioma have smaller-sized meningiomas and more advanced BCs compared with women having only 1 diagnosis. As there was no temporal relationship between size and latency between tumor diagnoses, the disparity in meningioma size between BC-meningioma and meningioma cohorts may have BC-associated biological components that warrant further study.

According to these abstracts, I'd conclude that there are very few women with both breast cancer and meningioma (412 out of 279,821 in the last paper).  As it is a very rare/unusual circumstance, it sounds like there is a lot that is not known.

Classic LCIS.If knowledge can create problems, it is not through ignorance that we can solve them- Isaac Asimov Dx 12/8/2005, LCIS, ER+/PR- Surgery 1/24/2006 Lumpectomy: Left Hormonal Therapy 7/15/2006 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Sep 24, 2014 12:46AM kazamodia wrote:

thx a lot leaf ... that really relieved me a lot

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Apr 23, 2015 07:37PM - edited Apr 23, 2015 07:52PM by sas-schatzi

Never saw this topic when it was first written. Doing a search tonight b/c I need to be proactive on f/u that I think may be a bit laid back on. This web page came up on google. Hmmm. must revist this topic. It happened to me. Meningioma and BC dx'd same day. Still kicking 6years out from BC and 3 years out post crani.

Enrolled in a study at Moffitt Cancer Center Re Bc & meningioma. Study involves southeastern USA. Increased incidence of both seen in se Usa. Forget what the term of the study length is, I was entered after the crani.

Based on reading here and elsewhere------------I'm rare.  Hmm great, now to convince the doc to be a little more concerned. Plus, another cancer-thyroid. All three are under the broad category neuroendocrine. 


Life's journey is not to arrive at the grave safely in a well preserved body, but rather to skid in sideways, totally worn out shouting "holy crap....what a ride".
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Aug 18, 2018 09:08PM - edited Aug 18, 2018 09:15PM by ClementineC

Hi there, I hope anyone could help me in understanding the above mentioned article.

When I was dxd with a brain met of which my radiologist first thought it to be a meningioma. He sent the MRI images to colleagues, professors and relatives but all radiologists and oncologists theirselves to get other opinions. All of them thought aswell it was meningioma bc it was quite big, noninvasive and only repressing. Tumor margins were clearly visible. I didn't develop symptoms apart from headaches at some time until a couple of weeks before dx when size was around 5-6cm (a clear pro for meningioma)

After taking it out and sending to pathology the results were „diffuse infiltrates of a known mamma carcinoma“ (after having it tested for ONLY breast cancer antigenes)

Big question: could it possibly have been a meningioma growing since first dx in 2013? Floating tumor cell found shelter in it before stage4 dx in 2017 and grew infiltrating the meningioma that much that pathologists may have had a sample full of bc cells (infiltrates)rather than a solid metastasis?

@leaf: If I understand your reply correctly this is a rare condition but can happen.

It all came up because I found the I never read before.

Dx 2013, IDC, 1cm, Stage IIA, Grade 3, 4/11 nodes, ER+/PR+, HER2+ (FISH) Dx 2017, Stage IV, metastasized to brain/liver, ER-/PR-, HER2+ (IHC)
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Sep 16, 2018 05:31PM - edited Sep 16, 2018 05:37PM by sas-schatzi

Clemetine--------when I was at my post op visit for the meningioma at a moffitt a NCCN center in 2012, I was enrolled in a study as was stated in the previous post. 

What happens at a NCCN center is multiple folks come in individually to ask the same questions, They then go back and compare "Reponses". That's  my estimation after going through it several times.

MY research in 2009, showed that Meningioma's can be estrogen supported or the origin of estrogen. So, a meningioma estrogen could feed a breast tumor or the reverse a breast tumor could feed a meningioma. From my research in 2009,  I reduced the information to this BC<------->M

BC<------> M. BC is breast cancer and M is meningioma. The arrows mean that the cancer can go in both directions as the research showed that meningiomas could be estrogen positive and could cause the Breast cancer and vis versa.. It was shocking to me. BUT in deciphering the information, I came to the simple equation above. BC <------->M. When I presented this to the staff at Moffitt, their eyes glazed over. i.e. they weren't listening.  So, if it happens in the future that a finding that it can go in either direction...…………..NO one will ever remember, I made a connection...…...YET they entered me into a study of "BC and M" in southeast USA. Kind of a slap in the face. They were looking for an answer and I gave it to them.

The key is all meningioma's need to be hormone tested

Life's journey is not to arrive at the grave safely in a well preserved body, but rather to skid in sideways, totally worn out shouting "holy crap....what a ride".
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May 6, 2019 06:09AM LindaSoG wrote:

I am seeing posts on this topic in some Meningioma groups I am in. I had my first Meningioma surgically removed in 1998, there was no cancer and no genetic testing done back then. I had a second meningioma that was likely regrowth from the first treated with radiation ten years later, in 2008. Ten years after that, I am diagnosed with Invasive Ductal Carcinoma. Is there a connection with the meningiomas? or maybe the radiation treatment ten years ago? I am still waiting for genetic testing to come back, it could be genetic.

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May 6, 2019 08:08AM Moderators wrote:

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