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Jul 9, 2018 12:01PM
Jul 9, 2018 12:04PM
Mayo did a study, replicated by Vanderbilt, published in The New England Journal of Medicine Dec 31, 2014
https://www.sciencedaily.com/releases/2014/12/1412... WOMEN WITH ATYPICAL HYPERPLASIA ARE AT HIGHER RISK OF BREAST CANCER
"The researchers were able to give an even more accurate estimate of risk by incorporating information from a patient's pathology specimen. They found that as the extent of atypia in a biopsy increased, as measured by the number of separate atypia lesions or foci, so did the woman's risk of developing breast cancer. For example, at 25 years post-biopsy, 47 percent women with three or more foci of atypia in the biopsy had developed breast cancer, compared to only 24 percent of women with one focus."
"Instead of relying on a statistical model, our study provides actual data of breast cancer cases that occurred in a population of women with atypia. These absolute risk data are preferable to a hypothetical model," says Amy Degnim, M.D., co-lead author and a breast surgeon at Mayo Clinic."
"Based on these results, the research team recommends that women with atypical hyperplasia be recognized as having significantly increased lifetime risk of breast cancer and thus be candidates for screening MRI. Moreover, anti-estrogen medications like tamoxifen have already been tested in clinical trials in women with atypia and shown to lower their risk of breast cancer by 50 percent or more."
I have a Mayo appt. several months from now and I want to find out more about this study. This study also indicates it may be valuable to ask how many foci are found in the biopsy.
When I originally read the article, linked above, it was formatted differently and included the graph shown here. Now that graph is absent in the linked article.
These #s are higher than what I had expected and the level of risk definitely has my attention.