Ingerp
Charlottesville, VA, USA
Joined:
Apr 2016
Posts:
2,553
Latest activity:
Jul 3, 2020
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Jun 19, 2019 08:10AM
Ingerp
wrote:
Most breast cancers are not genetic. It might well be that your daughter only has an average risk.
Dx
3/11/2016, DCIS, Left, 6cm+, Stage 0, Grade 3, ER-/PR-
Surgery
3/23/2016 Lumpectomy
Surgery
4/20/2016 Lumpectomy: Left
Radiation Therapy
5/18/2016 Whole-breast: Breast
Dx
3/2/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2+ (FISH)
Surgery
3/13/2018 Lumpectomy: Right; Lymph node removal: Sentinel
Targeted Therapy
5/18/2018 Herceptin (trastuzumab)
Chemotherapy
5/18/2018 Taxol (paclitaxel)
Radiation Therapy
8/20/2018 Whole-breast: Breast
Salamandra
Brooklyn, NY
Joined:
Oct 2018
Posts:
946
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Jul 2, 2020
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Jun 19, 2019 02:14PM
Salamandra
wrote:
Your spouse might want to be tested for the common genetic mutations. If your spouse is a woman, she should also start getting mammograms younger. If your spouse were to test positive, that would indicate testing your daughter as well. If not, then that is a good sign your daughter is clear from *known* genetic risk factors.
Dx at 39. 1.8cm. Oncotype 9.
Dx
9/19/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH)
Surgery
10/18/2018 Lumpectomy; Lymph node removal: Sentinel
Hormonal Therapy
11/1/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Radiation Therapy
12/3/2018 Whole-breast: Breast
Hormonal Therapy
12/19/2019 Fareston (toremifene)
Abi813
Joined:
Jun 2019
Posts:
2
Latest activity:
Jun 23, 2019
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Jun 19, 2019 02:31PM
Abi813
wrote:
Hi it's my Husband's Mum. My husband has been referred to have genetic counseling/screening in order to see if he has the mutated gene and if clear it will be a big sigh of relief for my daughter...
Beesie
Joined:
Jan 2006
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10,267
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Jul 3, 2020
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Jun 19, 2019 02:33PM
Beesie
wrote:
If your mother-in-law had a genetic mutation that predisposed her to breast cancer, then your husband had a 50% chance of inheriting this mutation from his mother. If he did inherit it, then your daughter had a 50% chance of subsequently inheriting this mutation from him. If your husband did not inherit the mutation from his mother, then there is no chance that your daughter could have inherited this risk.
So a 50% chance for your husband, followed by a 50% chance for your daughter, which means there there is a 25% chance that your daughter might have inherited this risk. BUT that's assuming that your MIL had a genetic mutation that caused her breast cancer. In fact only 10% - 15% of breast cancers are caused by genetic mutations. The young age at which your MIL was diagnosed would increase this probability, but even if there's a 50% chance that your MIL carried a breast cancer gene, that calculates to only a 12.5% chance that your daughter might have inherited the gene. (50% X 50% X 50%)
Are there other types of cancer within your MIL's line of the family? Cancers that may be related to some of the more common breast cancer genes include ovarian cancer and prostate cancer, and to a lesser degree, pancreatic cancer, colon cancer and various others. If there are no other cancers within the line of the family, then the odds are pretty good that there is no genetic mutation within the family.
“No power so effectually robs the mind of all its powers of acting and reasoning as fear.” Edmund Burke