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Topic: Breast cancer risks

Forum: High Risk for Breast Cancer — Due to family history, genetics, or other factors.

Posted on: Jun 19, 2019 06:44AM

Abi813 wrote:

Hi My mother in law had breast cancer aged 39/40. What are the chances of our daughter getting it? Thanks

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Jun 19, 2019 08:10AM Ingerp wrote:

Most breast cancers are not genetic. It might well be that your daughter only has an average risk.

Dx 3/11/2016, DCIS, Left, 6cm+, Stage 0, Grade 3, ER-/PR- Surgery 3/23/2016 Lumpectomy Surgery 4/20/2016 Lumpectomy: Left Radiation Therapy 5/18/2016 Whole-breast: Breast Dx 3/2/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2+ (FISH) Surgery 3/13/2018 Lumpectomy: Right; Lymph node removal: Sentinel Targeted Therapy 5/18/2018 Herceptin (trastuzumab) Chemotherapy 5/18/2018 Taxol (paclitaxel) Radiation Therapy 8/20/2018 Whole-breast: Breast
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Jun 19, 2019 02:14PM Salamandra wrote:

Your spouse might want to be tested for the common genetic mutations. If your spouse is a woman, she should also start getting mammograms younger. If your spouse were to test positive, that would indicate testing your daughter as well. If not, then that is a good sign your daughter is clear from *known* genetic risk factors.

Dx at 39. 1.8cm. Oncotype 9. Dx 9/19/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 10/18/2018 Lumpectomy; Lymph node removal: Sentinel Hormonal Therapy 11/1/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 12/3/2018 Whole-breast: Breast Hormonal Therapy 12/19/2019 Fareston (toremifene)
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Jun 19, 2019 02:31PM Abi813 wrote:

Hi it's my Husband's Mum. My husband has been referred to have genetic counseling/screening in order to see if he has the mutated gene and if clear it will be a big sigh of relief for my daughter...

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Jun 19, 2019 02:33PM Beesie wrote:

If your mother-in-law had a genetic mutation that predisposed her to breast cancer, then your husband had a 50% chance of inheriting this mutation from his mother. If he did inherit it, then your daughter had a 50% chance of subsequently inheriting this mutation from him. If your husband did not inherit the mutation from his mother, then there is no chance that your daughter could have inherited this risk.

So a 50% chance for your husband, followed by a 50% chance for your daughter, which means there there is a 25% chance that your daughter might have inherited this risk. BUT that's assuming that your MIL had a genetic mutation that caused her breast cancer. In fact only 10% - 15% of breast cancers are caused by genetic mutations. The young age at which your MIL was diagnosed would increase this probability, but even if there's a 50% chance that your MIL carried a breast cancer gene, that calculates to only a 12.5% chance that your daughter might have inherited the gene. (50% X 50% X 50%)

Are there other types of cancer within your MIL's line of the family? Cancers that may be related to some of the more common breast cancer genes include ovarian cancer and prostate cancer, and to a lesser degree, pancreatic cancer, colon cancer and various others. If there are no other cancers within the line of the family, then the odds are pretty good that there is no genetic mutation within the family.

“No power so effectually robs the mind of all its powers of acting and reasoning as fear.” Edmund Burke

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