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All TopicsForum: Canadians Affected by Breast Cancer → Topic: Kisqali (ribociclib)

Topic: Kisqali (ribociclib)

Forum: Canadians Affected by Breast Cancer —

Canadian health care, clinical trials, and life in general in the north.

Posted on: Sep 13, 2017 07:01PM

flwr57 wrote:

Any Canadian Stage IV ladies receiving this drug in combination with letrozole as a first line treatment?

My oncologist suggested this study and I would appreciate hearing from any one who may be taking part and is willing to share their experiences.

Thanks!


Oncotype DX 18 (12%) Dx 1/3/2014, IDC, Right, 2cm, Stage IIA, Grade 1, 0/6 nodes, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 2/19/2014 Lumpectomy: Right Radiation Therapy 5/8/2014 Breast Hormonal Therapy 7/1/2014 Arimidex (anastrozole) Dx 8/25/2017, IDC, Stage IV, metastasized to bone/liver/lungs
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Sep 15, 2017 08:16AM flwr57 wrote:

Hi Moderators,

Do you have any suggestions as to where I could post my question to get a response?


Oncotype DX 18 (12%) Dx 1/3/2014, IDC, Right, 2cm, Stage IIA, Grade 1, 0/6 nodes, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 2/19/2014 Lumpectomy: Right Radiation Therapy 5/8/2014 Breast Hormonal Therapy 7/1/2014 Arimidex (anastrozole) Dx 8/25/2017, IDC, Stage IV, metastasized to bone/liver/lungs
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Sep 15, 2017 03:16PM AnimalCrackers wrote:

Hi flwr57 - I'm afraid there aren't many people on this board who are on Kisqali (ribociclib) let alone from Canada.  I am in a clinical trial for Kisqali and an oral SERD called LSZ102 (it's like faslodex but oral).  I have a thread for my clinical trial you can check out.  There is also a thread for people on Kisqali and letrozole but only a few people have posted there.  Most people are on Ibrance (palbociclib) and letrozole or faslodex.  Ibrance had earlier FDA approval and received most of the attention and lion's share of the market.  Ibrance failed me after a year so I went to the clinical trial in May.  

There are some very savvy people in the ibrance thread, bone mets thread and liver mets thread.  A lot of Canadians in those threads too.  You may want to check them out and post there.

Do you have more information on the study your oncologists are suggesting?

Welcome to BCO - sorry you are here but glad you found us.  There is a great support system here and tons of knowledgeable people.  Good luck.  I'll be looking for you on the other threads.

Cathy


Cathy, diagnosed Stage IV de novo June 2014 (age 52). Bone mets at initial diagnosis (2014). Progression to Liver April 2017. Bisphosphonate infusions (Zometa) every 3 months. Clinical Trial 5/18/17 LSZ102 (oral SERD) and Kisqali (Ribociclib). Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali
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Sep 17, 2017 09:02AM flwr57 wrote:

Hi AnimalCrackers - Thanks so much for your reply! This was just what I was looking for.

Here is a link for the study my oncologists are suggesting.

NCT02941926 

https://clinicaltrials.gov/ct2/show/NCT02941926?term=compleement&rank=1 

I am very grateful for the support system offered by the people on BCO. 

J.

Oncotype DX 18 (12%) Dx 1/3/2014, IDC, Right, 2cm, Stage IIA, Grade 1, 0/6 nodes, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 2/19/2014 Lumpectomy: Right Radiation Therapy 5/8/2014 Breast Hormonal Therapy 7/1/2014 Arimidex (anastrozole) Dx 8/25/2017, IDC, Stage IV, metastasized to bone/liver/lungs
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Sep 17, 2017 10:04AM MissMonty wrote:

Hi flwr57,

I am in Ontario too, (I am being treated at Princess Margaret) and although I'm still pre-menopausal, I am doing a lot of research on hormone targeted therapies.  I look forward to hearing about your experience, if you do decide to participate in the trial.  The information I have uncovered so far looks very promising.

Anna


Hormonal Therapy 6/14/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 6/16/2017, IDC, Left, 4cm, Stage IV, metastasized to lungs, Grade 2, ER+/PR-, HER2- Chemotherapy Xeloda (capecitabine)
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Oct 11, 2017 03:48PM rethink_breast_cancer wrote:

My name of MJ DeCoteau and I am the executive director of Rethink Breast Cancer.

We are looking for woman who have been treated with ribociclib (Kisqali) to talk about their treatment experience.

You can find more information in the Stage IV and Metastatic Breast Cancer forum or you can send me a private message if you would be willing to participate.

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Oct 17, 2017 04:36PM flwr57 wrote:

I found out two weeks ago that I cannot participate in this study. After having additional scans, blood work and ECG, I found out that the research coordinator of the regional cancer program I attend missed an important detail about the anastrozole I was taking since July 2014. "If the prior neo (adjuvant) therapy included letrozole or anastrozole the disease free interval must be greater than 12 months from the completion of treatment until study entry." I stopped taking anastrozole August 2017 when I learned of the stage IV diagnosis.

Since then, my husband's insurance (I am retired) has denied funding Ibrance/fulvestrant. I have been waiting to hear if Afinitor/Aromasin will be approved. I just heard today that these meds will be approved. I am relieved but the waiting is terrible!

Oncotype DX 18 (12%) Dx 1/3/2014, IDC, Right, 2cm, Stage IIA, Grade 1, 0/6 nodes, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 2/19/2014 Lumpectomy: Right Radiation Therapy 5/8/2014 Breast Hormonal Therapy 7/1/2014 Arimidex (anastrozole) Dx 8/25/2017, IDC, Stage IV, metastasized to bone/liver/lungs
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19 hours ago flwr57 wrote:

Back from the oncologist today and a targeted therapy is not for me right now because the oncologist is concerned about progression in my liver. I start chemotherapy tomorrow, three cycles of Taxol - infusion week 1, week 2 and off week 3.

I wish all who are fortunate enough to participate on the ribo trials all the best!

Oncotype DX 18 (12%) Dx 1/3/2014, IDC, Right, 2cm, Stage IIA, Grade 1, 0/6 nodes, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 2/19/2014 Lumpectomy: Right Radiation Therapy 5/8/2014 Breast Hormonal Therapy 7/1/2014 Arimidex (anastrozole) Dx 8/25/2017, IDC, Stage IV, metastasized to bone/liver/lungs

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