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Topic: Anyone able to stay on Wellbrutin while taking hormone therapy?

Forum: Managing Side Effects of Breast Cancer and Its Treatment —

This is a place to discuss concerns, tips and strategies for all types of side effects from all types of medications and treatments, (chemo/rads/hormonal/targeted/pain meds/etc.

Posted on: Aug 10, 2019 07:34PM

aprildawn714 wrote:

I do not want to switch my anti depressant. I told my family doctor I would have to start hormone therapy after my surgery. She told me she has a lot of patients that take Wellbutrin with these meds. I am reading all of the horrible side effects I will have to deal with starting this crap. I don't want to change my other medication and have to deal with side effects from that as well. I am pre menopausal and I have researched them all and I don't think I can take some of them that the Welbrutin won't interact with. Any insight would be great Thanks!

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Aug 14, 2019 06:59PM ChelseaSculler wrote:

I've stayed on Wellbutrin while being on Tamoxifen. My MO has been on board, did not even suggest changing it (and as his colleagues remind me, he has 40 years of experience!). He says it's been mouse experiments and not backed up with people, so not to worry. (That said, I'm not on the Wellbutrin right now.)

DX 49.5 Dx 3/21/2018, IDC, Left, 1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 4/9/2018 Lumpectomy: Left; Lymph node removal: Sentinel Radiation Therapy 6/6/2018 Whole-breast: Breast Hormonal Therapy 7/31/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 14, 2019 08:25PM - edited Aug 15, 2019 11:33AM by vlnrph

To clarify, try looking up the generic name buproprion when you search for info. It is more of a combination serotonin-norepinephrine reuptake inhibitor as compared to the SSRIs which can also have interactions with the enzyme that activates estrogen receptor blockade.

April, you will certainly not experience all the side effects you read about. It is good to educate yourself in order to know what you mightexpect but it's not always worst case scenario for everyone! I was able to tolerate tamoxifen just fine.

IDC too! 🎻💊👪🐩 🇫🇮 🌹🦋 Rt MX+DIEP 4-2011; ALND 5-2011 d/t micromets; TC X 4; tamoxifen; lymphedema 9-2011; switch to letrozole 3-2014 for 1 yr; bone mets 8-2018: Zometa, rads to spine, Faslodex/Versenio Dx 3/7/2011, ILC, 2cm, Stage IIA, Grade 2, 1/25 nodes, ER+/PR+, HER2-
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Aug 15, 2019 06:03AM aprildawn714 wrote:

Thanks for the reply. I just read that you can't take the 2 meds because the Welllbrutrin causes the Tamoxifen to be less effective. I asked my family dr and she said she has quite a few patients that take both? So I was confused about it.

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Aug 15, 2019 07:12AM aprildawn714 wrote:

Chelseasculler I am so happy to hear this! Have you had any problems with the Tamoxifen?

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Aug 15, 2019 11:15AM Tresjoli2 wrote:

there are 4 antidepressants that do not conflict with tamoxifen: lexapro, celexa, effexor, and trintellix. Wellbutrin is not safe to take, as it will undermine your tamoxifen's effectiveness. You should either chose ovarian suppression and an AI, or switch antidepressants.

Good Luck!

Diagnosed at age 40 after going for my baseline mammogram. Dx 4/21/2015, IDC, Left, <1cm, Stage IA, 0/2 nodes, ER+/PR+, HER2+ (FISH) Dx 4/21/2015, DCIS, Left, 4cm, Stage 0, Grade 3 Surgery 5/18/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 6/19/2015 Herceptin (trastuzumab) Chemotherapy 6/19/2015 Taxol (paclitaxel) Chemotherapy 8/7/2015 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 9/23/2015 Whole-breast: Breast Hormonal Therapy 10/11/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 15, 2019 11:32AM aprildawn714 wrote:

I haven't gone through menopause so I can't take the others from what I have rea

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Jan 19, 2020 03:05PM deweygirl19 wrote:

Aprildawn71 what did Your MO say? I’m in the same boat, terrified of having to change to something other than Wellbutrin. And also terrified of OS+AI. As if breast cancer hasn’t caused enough havoc in our lives, it seems that I have no good choices.

Dx at 42 Dx 8/9/2019, IDC, Right, 1cm, Grade 2, 0/4 nodes, ER+/PR+, HER2- (FISH) Surgery 9/30/2019 Lumpectomy: Right; Reconstruction (left); Reconstruction (right) Radiation Therapy 12/15/2019 Whole-breast: Breast Hormonal Therapy 1/31/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 19, 2020 05:40PM Salamandra wrote:

I didn’t tolerate tamoxifen and I was able to persuade my doctor to support me trying toremifene. (I persuaded her to actually check with her department’s senior oncologist, he convinced her). It’s not FDA approved for premenopausal women but there’s solid evidence (according to me and more importantly the senior oncologist) that it is at least as effective as tamoxifen.

Bonus, it is completely compatible with Wellbutrin. (And at least so far, I’m tolerating it much better than tamoxifen).

I found more than one article suggesting that it could be suitable as a first line drug for premenopausal women whose other health conditions (like depression successfully treated with Wellbutrin) contraindicate tamoxifen, and second line treatment for women who can’t tolerate tamoxifen.

It makes me angry that my doctor at a top notch research hospital didn’t offer it to me proactively. She was pushing to move on to OS+AI. But I’m relieved that it’s out there as an option

Dx at 39. 1.8cm. Oncotype 9. Dx 9/19/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 10/18/2018 Lumpectomy; Lymph node removal: Sentinel Hormonal Therapy 11/1/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 12/3/2018 Whole-breast: Breast Hormonal Therapy 12/19/2019 Fareston (toremifene)
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Jan 25, 2020 07:54PM aprildawn714 wrote:

to tell you the truth I am in the process of changing MOs. Considering she didn't even notice I was on both meds! And she also didn't even bother to notice I did not have chemo or radiation when I came to see her for the second time. LIke she never even looked at my records. I sat at the office for over 2 hours to see her both times and I was the first scheduled appt. Not happy....I will let you know what my new Dr says for sure about the meds being taken together I see him in a few weeks

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Sep 13, 2020 07:21PM aprildawn714 wrote:

I wish I could just switch to this and keep my Wellbutrin. I’m weening myself off my Wellbutrin and I’m feeling the difference in my mood. And the tamoxifen is making me tired and more moody and no sex drive

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Sep 13, 2020 07:29PM aprildawn714 wrote:

what did you end up doing about your Wellbutrin? I’m slowly weaning myself off and I’m not happy. Seeing my primary dr next month to try another antidepressant.

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