Topic: Ibrance/Palbociclib/Pallas trial... experiences?

Forum: Stage III Breast Cancer — You are not alone. Meet others who have Stage III breast cancer.

Posted on: Jan 19, 2018 01:59PM

Posted on: Jan 19, 2018 01:59PM

Anna-33 wrote:

Hello

Because of my massive positive lymphnodes I might say yes to the Pallas trial... Other? Or anyone with experience with this medicine? Still nerd to Get randomised though..

Dx 3/1/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 8/25 nodes, ER+/PR-, HER2-
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Jul 6, 2018 05:30AM Lexica wrote:

Hi, Anna, just wondering how you are doing - are you still in the study? I go for my cycle 2 blood work today (this time last cycle, I had to take a week off). I've been feeling so tired - maybe even chemo level tired - lately that I think that my blood counts must be low. Then again, it is sweltering outside, so maybe it's the heat? One can hope...

Diagnosed at 34. 2 years of Ibrance via PALLAS trial (ends 4/2020) Dx 7/2017, IDC, Left, Stage IIIC, Grade 2, ER+/PR+, HER2-, Surgery 12/14/2017 Lymph node removal: Sentinel; Mastectomy: Left; Prophylactic mastectomy: Right Dx 12/27/2017, DCIS/IDC, Left, 6cm+, Stage IIIA, Grade 3, 5/11 nodes, ER+/PR+, HER2-, Radiation Therapy 1/15/2018 Whole breast: Breast, Lymph nodes, Chest wall Chemotherapy AC + T (Taxol) Hormonal Therapy Aromasin (exemestane)
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Jul 6, 2018 06:04AM Lallasus wrote:

I am afraid I have had to come off the study as blood count was too low. Three strikes and your out I have stayed on in the control group however

Dx 6/2018, Right, 6cm+, Stage IIIA, Grade 2, 1/2 nodes, ER+/PR-, HER2- Radiation Therapy Lymph nodes, Chest wall Surgery Mastectomy: Right Hormonal Therapy Arimidex (anastrozole)
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Jul 6, 2018 09:30AM Anna-33 wrote:

I am still in... 100mg... my bloodcounts are on the limit... I was hospitalized for a few days on this cycle due to infection...

Dx 3/1/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 8/25 nodes, ER+/PR-, HER2-
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Jul 17, 2018 04:06AM Anna-33 wrote:

How are everyone you doing?

What have your oncologists said about Ibrance, do they belive in it?

New members included? How can we reach out to new members in this tread?

Dx 3/1/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 8/25 nodes, ER+/PR-, HER2-
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Jul 17, 2018 12:37PM Billb464 wrote:

hi, I just started the Pallas trial last week. So far no SE with it or the tamoxifen, I know that might/will change as I am on it longer. I have my 1st blood work on Monday, so I’m interested in seeing if it has changed. My MO said that anything extra added could always make a difference in the future, so it was worth a try



Dx 8/6/2017, IDC, Right, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2-, Chemotherapy 8/23/2017 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 1/9/2018 Lumpectomy: Right; Lymph node removal: Underarm/Axillary; Reconstruction (right): Fat grafting, Latissimus dorsi flap Dx 1/10/2018, DCIS/IDC, Right, 2cm, Stage IIB, Grade 1, 2/6 nodes, ER+/PR+ Radiation Therapy 3/1/2018 Whole breast: Breast, Lymph nodes Hormonal Therapy 4/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 7/7/2018 Ibrance (palbociclib) Hormonal Therapy
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Jul 20, 2018 11:57AM Lexica wrote:

Lallasus - sorry you got booted from the drug arm.

Anna - are you still doing okay? How were your latest counts. I've had two MO's that seem pretty supportive of Ibrance. One is the PI for the study, so, I'm not surprised that she is supportive of it. The other one (a breast cancer specialist at the NIH...I see him when I can as he has one clinic day where I receive my treatment) didn't know too much about the study, but his statement was "things that tend to work well in the metastatic setting work even better in early stages." So, that's good. I know Ibrance has been touted as a highly effective treatment for metastatic BC.

Billb464 - welcome :) How are you doing so far?

My fatigue has continued to be a challenge the past couple weeks. Any one on this and still working full time? I've got two little ones, too, so I know that alone will tire me out, but it seems worse than it should be.

Diagnosed at 34. 2 years of Ibrance via PALLAS trial (ends 4/2020) Dx 7/2017, IDC, Left, Stage IIIC, Grade 2, ER+/PR+, HER2-, Surgery 12/14/2017 Lymph node removal: Sentinel; Mastectomy: Left; Prophylactic mastectomy: Right Dx 12/27/2017, DCIS/IDC, Left, 6cm+, Stage IIIA, Grade 3, 5/11 nodes, ER+/PR+, HER2-, Radiation Therapy 1/15/2018 Whole breast: Breast, Lymph nodes, Chest wall Chemotherapy AC + T (Taxol) Hormonal Therapy Aromasin (exemestane)
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Jul 20, 2018 03:16PM Anna-33 wrote:

My bloodcounts jumps between 0,7 and 1.0 (neutrophils). Hope to stay on this dose as long as possible (100mg).

I feel a kind of fatigue (loss of power) and need a lot of sleep (that I only could dream about with my two kids 1 year and 4 years old) .

How are your bloodcounts?

I have finished half a year with Ibrance now....

Dx 3/1/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 8/25 nodes, ER+/PR-, HER2-
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Jul 22, 2018 08:30PM notmargaret wrote:

Hi All. Just responding to Anna's general request for status . . . I've just about made it through 8 cycles at 125 mg and will have another round of blood tests in about two weeks. My neutrophils have been consistently low since starting the trial, hovering right around 1.0. My oncologists were optimistic that the Ibrance would be beneficial.

Dx 12/2016, ILC, Left, 6cm+, Stage IIIA, Grade 2, 8/27 nodes, ER+/PR-, HER2- Surgery 3/29/2017 Prophylactic ovary removal Surgery 8/29/2017 Lymph node removal; Mastectomy Radiation Therapy 10/15/2017 Whole breast: Lymph nodes, Chest wall Targeted Therapy 12/10/2017 Ibrance (palbociclib) Hormonal Therapy Arimidex (anastrozole) Chemotherapy AC + T (Taxol)
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Jul 23, 2018 12:34PM Billb464 wrote:

thank you lexica, I am feeling pretty good so far, I am still exercising as much as I can each day (I try to get in 5-6 miles at the park). I have noticed a little bit of soreness in my legs, but not sure if that is just general age stuff.😉I had my 1 st blood test today- the 2 week mark and will be interested to see if things have changed any. I start back to school next week, and the students come back the week after, so hoping no infection problems, I did work thru chemo last year and didn’t have any problems. I have noticed a little bit of nausea at times, does any one else have that problem?

Dx 8/6/2017, IDC, Right, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2-, Chemotherapy 8/23/2017 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 1/9/2018 Lumpectomy: Right; Lymph node removal: Underarm/Axillary; Reconstruction (right): Fat grafting, Latissimus dorsi flap Dx 1/10/2018, DCIS/IDC, Right, 2cm, Stage IIB, Grade 1, 2/6 nodes, ER+/PR+ Radiation Therapy 3/1/2018 Whole breast: Breast, Lymph nodes Hormonal Therapy 4/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 7/7/2018 Ibrance (palbociclib) Hormonal Therapy
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Aug 28, 2018 08:32AM Z11 wrote:

Hi! I elected to do the trial and am just coming up on my initial 2 weeks. I will have a lab check tomorrow. I am considered high risk for reoccurrence, therefore, my breast surgeon, oncologist and the oncologist who provided me a second opinion all highly recommended it. I was diagnosed at stage IIB with positive lymph nodes. As far as randomizing, you will be randomly selected to either receive the drug or will be randomized to not. I was happy I was randomized to receive it. The cycle is 3 weeks of the drug followed by one week off. I hope this sliver of information helps :)

Z :) Dx 9/11/2017, DCIS/IDC, Right, 3cm, Stage IIB, Grade 2, 2/5 nodes, ER+/PR+, HER2-, Surgery 9/26/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right Chemotherapy 10/31/2017 Abraxane (albumin-bound or nab-paclitaxel), Adriamycin (doxorubicin), Cytoxan (cyclophosphamide) Radiation Therapy 4/19/2018 3DCRT: Lymph nodes Hormonal Therapy 7/8/2018 Arimidex (anastrozole) Targeted Therapy 8/15/2018 Ibrance (palbociclib) Surgery Prophylactic ovary removal

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