Topic: Stage III and Verzenio

Forum: Stage III Breast Cancer — You are not alone. Meet others who have Stage III breast cancer.

Posted on: Jan 23, 2021 06:35PM

Posted on: Jan 23, 2021 06:35PM

GraceBer wrote:

I may need to venture into the mets forum for SE coping strategies, but I’m wondering if there’s anyone else who’s been put on Verzenio (vs Ibrance or Kisquali) to prevent recurrence? My MSK oncs and Yale onc (I switched to Yale this past summer) all agreed that I should be put on a CDK 4/6 inhibitor. We waited until this fall (regional recurrence that made me stage III - DXed July 2019), due to finishing treatments and me pushing it off further due to Covid, to start. And though I was originally going to be put on Ibrance I was put on Verzenio due to its positive data coming out of the trial.

Oof! Verzenio has been rough. The Covid silver-lining is that being at home all the time is convenient for my now daily attacks of diarrhea, but I’ve got to get it under control because I want to have a better quality of life (especially in the Covid After Times).

Immodium is pretty effective at stopping the diarrhea after one or two episodes, but it hasn’t been effective used as a preventative. So, I’ve turned to probiotics a week ago. I’m taking a daily capsule of Align and trying to eat some yogurt every day. So far, I’m seeing no improvement with the probiotics.

I’m trying to up my water intake and have supplemented it with the Liquid IV powder (basically, healthier Gatorade - electrolytes with more vitamins and less sugar). That’s helping me with dehydration and keeping labs looking pretty good.

i’m taking 150mg - the recommended dose. If I can’t find a better way to manage the GI side effects, I think we’ll need to reduce my dose.

Ugh! This sucks 😕


Dx 11/26/2013, IDC, 2cm, Stage IIA, Grade 3, 0/3 nodes, ER+/PR+, HER2- Surgery 12/20/2013 Lumpectomy: Left Dx 7/17/2019, IDC, Left, <1cm, Stage IIIC, Grade 3, ER+/PR+, HER2-, Surgery 8/20/2019 Lymph node removal Radiation Therapy Whole breast: Breast, Lymph nodes, Chest wall Targeted Therapy Verzenio Hormonal Therapy Arimidex (anastrozole) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 27, 2021 04:54PM - edited Oct 28, 2021 04:58AM by scaredme

So far, so good with the reduced dose! Had my bloodwork done after 10 days on the med and my numbers were all within normal range. I will have bloodwork in another month, so hopefully things continue to go well! I am still having occassional bouts of diarrhea and nausea, but not terrible.

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Nov 19, 2021 04:07AM scaredme wrote:

I had bloodwork done yesterday after about 6 weeks on the reduced dose of 100 mg. My WBC was 2.84 (reference range is 4.00 - 10 K/uL) and my Absolute Neuts was 1.08 K/uL (reference range is 1.92-7.60 K/uL). The NP said that they were only concerned with the Absolute Neuts being above 1.0 K/uL, so they are keeping me on this dose for the time being. That said, I will be going off of the med in a week or so in preparation for my Exchange surgery on 12/9.

The side effects seem to be lessened considerably, with the exception of some nausea in the mornings. I have noticed a correlation with my hydration levels, so I am trying to stay better hydrated through the day.

Hope all of you are doing well.


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Dec 9, 2021 09:34PM divergent wrote:

How has everyone been doing? I finally started taking the Verzenio a few days ago. I've noticed strange side effects...my mouth and throat have been really dry. It's worse at night when I'm not drinking water. Lots of stomach cramps and my belly is puffed out like a balloon. The immodium definitely helps with the cramps and diarrhea. I haven't had bloodwork yet so I don't know that info. I really hope symptoms get better.

In phase 3 clinical trial for Keytruda (NCT03725059, Keynote-756) Dx 6/2019, IDC, Right, ER+/PR+, HER2- Chemotherapy 7/19/2019 AC + T (Taxol) Surgery 1/8/2020 Lumpectomy; Lumpectomy (Left); Lymph node removal; Lymph node removal (Right); Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Surgery 1/8/2020 Lumpectomy (Left) Radiation Therapy 2/6/2020 Whole breast Hormonal Therapy 3/1/2020 Femara (letrozole) Surgery 3/1/2021 Immunotherapy 12/1/2021 Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin)
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Dec 10, 2021 07:07AM juju-mar wrote:

hi all,

I'm into my 4th packet of Verzenio. The diarrhea was really bad n the 3rd week with pain and bloating. I've lost 4 pounds since I've started. Doc reduced my dosage to 100mg twice a day. I hope that helps! I really want to stay on this med. I take a probiotic daily and use Imodium when needed. I have Crohn's disease and it's been in deep remission for almost 30 years. The symptoms I was feeling reminded me of Crohn's pain which is similar to labor pains! No fun. Hope everyone is doing well.

Juli

Dx 8/27/2020, IDC, Right, 6cm+, Stage IIIA, Grade 3, 2/4 nodes, ER+/PR+, HER2- Chemotherapy 10/26/2020 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxol (paclitaxel) Radiation Therapy 6/13/2021 Whole breast: Breast, Lymph nodes
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Dec 10, 2021 12:51PM homemom wrote:

Is this for anyone with a stage III diagnosis regardless of grade or node involvement? Just curious before I go to the MO next week for my 6 month

Dx 3/31/2014, IDC, 2cm, Stage IIB, Grade 1, 3/29 nodes, ER+/PR+, HER2- Surgery 4/14/2014 Lumpectomy; Lumpectomy (Left) Surgery 5/5/2014 Lymph node removal; Lymph node removal (Left): Underarm/Axillary; Mastectomy; Mastectomy (Left); Reconstruction (Left): Tissue Expander Chemotherapy 5/29/2014 AC Chemotherapy 7/24/2014 Taxol (paclitaxel) Radiation Therapy 10/15/2014 Hormonal Therapy 12/14/2014 Arimidex (anastrozole)
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Dec 11, 2021 09:50AM juju-mar wrote:

I think so. Anyone with Stage 3 can use this area.

Juli

Dx 8/27/2020, IDC, Right, 6cm+, Stage IIIA, Grade 3, 2/4 nodes, ER+/PR+, HER2- Chemotherapy 10/26/2020 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxol (paclitaxel) Radiation Therapy 6/13/2021 Whole breast: Breast, Lymph nodes
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Dec 12, 2021 09:02PM sbelizabeth wrote:

HomeMom, if your question is about which breast cancer patients would be considered appropriate for Verzenio therapy, BCO has a good article about it here.

https://www.breastcancer.org/research-news/verzeni...

pinkribbonandwheels.wordpress.... Dx 10/20/2011, IDC/IBC, Left, 1cm, Stage IIIB, Grade 2, 6/28 nodes, ER+/PR+, HER2- Chemotherapy 12/15/2011 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 4/18/2012 Mastectomy; Mastectomy (Left) Radiation Therapy 5/21/2012 Breast, Lymph nodes Hormonal Therapy 7/19/2012 Femara (letrozole) Surgery 4/15/2013 Reconstruction (Left): DIEP flap; Reconstruction (Right): DIEP flap
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Dec 13, 2021 03:42PM notascalmasilook wrote:

I’ve been on verzenio for several months and now take 1/4 dose of immodium each day, which seems to do the trick reducing the diarrhea to once a day or not at all

Dx 7/2020, DCIS/IDC, Left, 6cm+, Stage IIIA, Grade 3, 4/12 nodes, ER+/PR-, HER2- Surgery Lymph node removal; Lymph node removal (Left): Underarm/Axillary; Mastectomy; Mastectomy (Left) Chemotherapy AC + T (Taxol)
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Dec 13, 2021 08:22PM divergent wrote:

How do u take 1/4 of a dose? Do u have to split the pill twice? I've started taking 2 pills a day (one before each verzenio dose). That seems to work so far. I have a lot of fatigue though.

In phase 3 clinical trial for Keytruda (NCT03725059, Keynote-756) Dx 6/2019, IDC, Right, ER+/PR+, HER2- Chemotherapy 7/19/2019 AC + T (Taxol) Surgery 1/8/2020 Lumpectomy; Lumpectomy (Left); Lymph node removal; Lymph node removal (Right); Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Surgery 1/8/2020 Lumpectomy (Left) Radiation Therapy 2/6/2020 Whole breast Hormonal Therapy 3/1/2020 Femara (letrozole) Surgery 3/1/2021 Immunotherapy 12/1/2021 Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin)
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Dec 13, 2021 09:03PM seeq wrote:

I'm not sure what NotAsCalm is using, but my MO suggested the liquid immodium for more precise measuring of smaller dosages - easier that cutting a pill in quarters.

De novo diagnosis with large/numerous liver mets. Breast lump identified one month later. Hormonal Therapy 7/3/2020 Arimidex (anastrozole) Targeted Therapy 7/10/2020 Verzenio

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