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Topic: Neupogen (g-shots) and Lower Back Pain

Forum: Chemotherapy - Before, During, and After —

Regimens, side effects, and support from others going through chemo.

Posted on: Sep 24, 2020 11:14AM

Sarabeara wrote:

Happy fall to all of you!!

I had my first round of TC a week and a half ago. I started my g-shots (Neupogen) on day 4. The evening of my 4th g-shot in ended up in the ER as I was neurogenic with a fever and was having excruciating lower back pain. I ended up getting admitting for the night until my fever was gone and WBC looked better.

The back pain was what I was hoping to get feedback on. IT WAS TRULY AWFUL. It absolutely reminded me of the back labor contractions I experienced with my first child. I delivered my children naturally and I can tell you that this pain was reaching the level of childbirth contractions. I took Claritin, as suggested by so many. I started the day before shots and continued through the duration of the series.

I am not sure I even know what I am looking for from you ladies, maybe just the comfort of knowing it happens, possible suggestions for prevention, or others experiences with pain and g-shots.


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Sep 24, 2020 08:20PM MinusTwo wrote:

Bone pain is one of the major side effects. I had Neulasta shots 24 hours after every chemo infusion. I learned on this site to take Claritin starting 2 days before chemo and continuing 7 days after my Neulasta shots. Not the "D" decongestant, just the regular Claritin. I was never sure how or why it worked, but it was a life saver.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Sep 28, 2020 10:13AM pabl48 wrote:

I had tremendous bone pain after my last TC infusion and then the Neulasta onPro. I did the Claritin with no success. This time around I am going to try Claritin, Pepcid and Advil prior to and for 5 days post infusion and see what happens.

Good luck to tou


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Sep 28, 2020 11:21AM Sarabeara wrote:

pabl48,

Sounds like we had similar experiences. I haven’t heard about using Pepcid, I will definitely look into that. Good luck to you on your next infusion, let me know how it goes. Sending good ju-ju your way!


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Sep 28, 2020 05:33PM - edited Sep 28, 2020 05:35PM by moth

I'm on daily desloratadine for a totally different reason & this time around the bone pain from the G-CSF shots is nothing like I remember from 2018; I really have hardly any bone pain at all this time. So if things don't improve, maybe try this antihistamine instead.

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab)
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Sep 28, 2020 06:14PM MinusTwo wrote:

Interesting Moth. I had to look it up. Thanks for posting.

Question: Is there a major difference between Claritin and Clarinex? Answer: Claritin is loratadine, which is metabolized in the liver to produce desloratadine, which is Clarinex.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Sep 29, 2020 05:00AM SoCalLisa wrote:

I had the worst pain I had ever had with neupogen. What I found was that if the dosage was lowered a bit, I got the same response but with a LOT less pain. Since I was giving myself the shots, I could control how many cc I gave myself. Why not ask the doctor about it.

Biography: DX 11/2000 LCIS,DCIS,IDC 2B, Grade 1, ER+,PR+ Her2Neg 1 pos node Lumptectomy, CMF chemo X 6 mos, DX 8/2001, IDC same breast--Mastectomy , Left Breast Lumpectomy... Tamoxifen, one year...Armidex, Four years
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Sep 29, 2020 08:41AM Sarabeara wrote:

SoCalLisa,

I will definitely ask my MO about this at our next appointment. I ended up being nuepogenic as well, so I am not sure if she is willing to reduce the dosage of the boosters, but it is absolutely worth asking, as the pain was unbearable.Thank you!!

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Sep 29, 2020 03:03PM SoCalLisa wrote:

my absolute neutrophil count was raised the same with the lesser dose..

Biography: DX 11/2000 LCIS,DCIS,IDC 2B, Grade 1, ER+,PR+ Her2Neg 1 pos node Lumptectomy, CMF chemo X 6 mos, DX 8/2001, IDC same breast--Mastectomy , Left Breast Lumpectomy... Tamoxifen, one year...Armidex, Four years

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