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Mar 3, 2008 11:37AM
Mar 3, 2008 11:37AM
Hi, Sheri and Minz. First off, let me say that you both are a phenomenal--your respective friends are both very fortunate to have you.
Sheri, regarding Lisa's path report--from her hormone and HER2 receptors, first off, it sounds like she has a very unusual presentation of ILC. ILC tumors are generally ER+/PR+ HER2-. Occasionally they are triple positive or triple negative, but this is the first one I've heard of that's ER-/PR- HER2+.
Second, yes, since she is ER-/PR-, she cannot take hormonal therapy like Tamoxifen or armotase inhibitors like Faslodex or Arimidex. The tumor is not hormone driven.
Since she is HER2 +, she will be put on Herceptin, which is a targeted therapy specifically designed to block the HER2 protein overexpression.
Grade 3 is different that stage. There are 3 grades of tumor, with grade 3 being the most aggressive.
So, the bad news is that she has a large tumor, high grade, hormone negative, HER2 positive. The good news is that the very aggressive tumors respond the best to chemo.
After surgery, she can be staged. Her lymph node status will be important. If she decides on chemo before surgery, it will be difficult to know what her lymph node status truly was going into all this. Something to consider when considering the neoadjuvant chemo route. I would encourage her to get several medical opinions before proceding.
I would also suggest you also check out www.her2support.org. My late mother was HER2 positive, and everything I learned about her disease I learned from that site.
Then I was diagnosed, and proceded to learn everything I needed to know about my disease from this site. The women here are fantastic. I hope that Sheri decides to join us, if nothing else just to read the posts. That's the beauty of this site--one can participate as much or as little as one wants. Sometimes just lurking is all one needs.
Stage IV Pleomorphic ILC, initially diagnosed at age 38
6/7/2007, ILC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 0/4 nodes, ER+/PR+, HER2- (FISH)
7/19/2007 Lumpectomy: Left; Lymph node removal: Sentinel
12/27/2007 Whole-breast: Breast, Chest wall
3/1/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
4/24/2015, ILC, Left, 1cm, Stage IV, metastasized to other, Grade 2, 0/10 nodes, ER+/PR+
5/15/2015 Mastectomy; Reconstruction (left): Latissimus dorsi flap
2/1/2018, ILC, Right, 6cm+, Stage IV, metastasized to other, Grade 3, ER+/PR+
2/15/2018 Cytoxan (cyclophosphamide), Taxol (paclitaxel), Taxotere (docetaxel)
6/20/2018, ILC, Both breasts, 6cm+, Stage IV, metastasized to brain/bone, Grade 3, ER+/PR+
7/1/2018 Ibrance (palbociclib)
7/17/2020, ILC, Both breasts, 6cm+, Stage IV, metastasized to brain/bone, Grade 2, ER+/PR+, HER2- (FISH)
7/17/2020 Xeloda (capecitabine)
Faslodex (fulvestrant), Zoladex (goserelin)