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Jun 27, 2008 10:39AM
I think the issue with ILC responding to chemo comes down to the fact that many ILC tumors are grade 1, which isn't going to respond well to chemo, whether it's ILC or IDC. More aggressive grade 2 or 3 (which tend to be pleomorphic, like Gitane and I have) will respond better to the chemo, as would a grade 2 or 3 IDC.
ILC is hard to grade, in general, and some pathologists don't even like to grade it at all, b/c they feel the Scarff-Bloom-Richardson scale used for bc in general doesn't fit ILC well (I think it has something to do with the tubular score). Anyhow, I've been told my pleomorphic ILC is really more like a grade 3 IDC, even though it was graded a 2 as ILC.
At any rate, I believe classic ILC is almost always a grade 1, thus the limited response to chemo in the neoadjuvant trials done at MD Anderson.
Stage IV Pleomorphic ILC, initially diagnosed at age 38
6/7/2007, ILC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 0/4 nodes, ER+/PR+, HER2- (FISH)
7/19/2007 Lumpectomy: Left; Lymph node removal: Sentinel
12/27/2007 Whole-breast: Breast, Chest wall
3/1/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
4/24/2015, ILC, Left, 1cm, Stage IV, metastasized to other, Grade 2, 0/10 nodes, ER+/PR+
5/15/2015 Mastectomy; Reconstruction (left): Latissimus dorsi flap
2/1/2018, ILC, Right, 6cm+, Stage IV, metastasized to other, Grade 3, ER+/PR+
2/15/2018 Cytoxan (cyclophosphamide), Taxol (paclitaxel), Taxotere (docetaxel)
6/20/2018, ILC, Both breasts, 6cm+, Stage IV, metastasized to brain/bone, Grade 3, ER+/PR+
7/1/2018 Ibrance (palbociclib)
7/17/2020, ILC, Both breasts, 6cm+, Stage IV, metastasized to brain/bone, Grade 2, ER+/PR+, HER2- (FISH)
7/17/2020 Xeloda (capecitabine)
Faslodex (fulvestrant), Zoladex (goserelin)