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Jun 28, 2016 03:21AM
Hi everyone, I hope you are all having a great start to summer!
KnitPurl, I didn't have any side effects whatsoever until Round 3. I am currently on Round 6. I have had zero nausea or diarrhea (and I'm not taking any anti-nausea meds). The only side effect I've had is hand/foot syndrome, and it's been totally fine. I still have been biking about 20 miles per day, despite the HFS. It has not been bad at all. My hands are totally fine (maybe a little dry?), but my feet have had some stinging on perhaps 5-6 days out of every 21. I am on 3750 mg/day (split half in am, half in pm). I am hoping to go up to 4250 for the last two rounds. I really don't have any other side effects, so I've been living my life 100% normally.
I do apply creams a few times a day. I don't really believe that the creams/lotions "cure" HFS or prevent it, but I think they help soothe the exterior symptoms (i.e. help with dryness, possible cracking, etc). Many people recommend Bag Balm (but I don't like the smell). Also any lotions with Urea (preferable 20%, but 10% ok). Udderly Smooth and Eucerin each make Urea-based lotions (but not ALL of their lotions contain urea, so you have to search the ingredients). Most recently, I read on the "All about Xeloda" thread about mixing your own lotion with T5 antioxidant, and I've been doing that and it is nice and seems to help. Here is a comment on that thread (Doxil has HFS like Xeloda does):
"I wanted to let all who are taking Doxil know, that I have been quite successful at neutralizing the effects of the drug on hands and feet. I compounded at home ingredients similar to what's described in the study above and it worked.
I waited two weeks after the administration of the first dose of Doxil; at that point especially the feet had started peeling, and were itching like crazy. In the meantime I had searched for and bought the crucial ingredient (anti-oxidant concentrate). I mixed it with a good emollient cream, and started applying it to hand and feet mornings and evenings. In less than a week, the side effects abated. Now they are much more bearable: no itching and almost no peeling. I'm still experimenting with different emollient creams, as the base, too see if one works better than the other; however, the active ingredient is the anti-oxidant. I've also found more research validating* the remedy (my oncologist had not heard about it, so I had to dig out more info for her). The manufacturer of the original remedy used in the studies is German but they don't export it to the US because FDA approval would cost top $ for a niche product."
And another person said this:
"I went to the dermatologist at MSKCC and he prescribed 0.05% clebetasol foam and salasylic acid for my hfs. I finally got the clebetasol yesterday so I'll let you know how.it works. I've used the salasylic for a few days now and it's helped a bit. I hope the combo does the trick!"
Basically, I've tried all the lotions I saw recommended, and I think they are all helpful.
Glad you didn't get a bad reaction! I remember I was so nervous to take that first dose! Now it is nothing.
4/2015, IDC, Right, 2cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2-
AC + T (Taxol)