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Topic: TNBC Vaccine Trial?

Forum: Triple-Negative Breast Cancer —

Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: Jul 7, 2017 09:21PM

Sam0623 wrote:

I believe a larger trial with more locations is opening soon (Mayo clinic in Jacksonville said later this year, but I know it has been delayed many times already.)

Does anyone know anything about this smaller one? (NCT02593227) I called today to get more information but haven't heard back yet. It appears after treatment there is no minimum amount of cancer you need to have left to participate. It is a little confusing though- one section says you can be stage I-III and another area says it is for IIb-III.

This trial interests me because the only other trial in my state I might be eligible for is a immunotherapy trial including Keytruda, but you have to have at least 1 cm of residual disease or positive nodes.

My MO is pretty excited about the immunotherapy outcomes so far, and the vaccine is also immunotherapy.

Has anyone talked ro their MO about this trial? Has anyone been offered this after getting a PCR?

Thanks!

Dx 2/14/2017, DCIS/IDC, Left, 2cm, Stage IIIA, Grade 3, 8/15 nodes, ER-/PR-, HER2- Chemotherapy 3/3/2017 AC Chemotherapy 4/28/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery 9/1/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Radiation Therapy 10/24/2017 Whole-breast: Breast, Lymph nodes, Chest wall Chemotherapy 12/15/2017 Xeloda (capecitabine) Surgery 10/1/2018 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jan 8, 2018 12:32AM Connie1230 wrote:

I will be having the last of the 6 monthly shots the end of this month. I also notice that I'm scheduled to go in again for labs and to see the dr. 4 weeks later, in Feb. I am wondering if anyone knows how often you will see the dr. Or have labs during the 6 mo period before the next injections. I will ask when I go back the end of this month but thought maybe someone's knew

Dx 7/1/2016, IDC, Left, 4cm, Stage IIB, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 8/24/2016 Lumpectomy; Lymph node removal: Sentinel Chemotherapy 10/10/2016 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxol (paclitaxel)
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Jan 8, 2018 09:44PM Angtee15 wrote:

Hi Connie,

I had my sixth shot in May 2017, then four weeks later went back for labs only and to see the doc as you mentioned. There have been no other visits needed and I only went back for my first booster last month. They told me to come back in June for booster #2. That's it!

Good luck everyone!


Dx 11/9/2015, IDC, Left, 2cm, Stage IIA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Chemotherapy 12/6/2015 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxol (paclitaxel) Surgery 5/11/2016 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Jan 9, 2018 09:25PM - edited Jan 9, 2018 09:26PM by Connie1230

Thanks Angtee15. I was hoping I wouldn't have to go back every month. Since it's a 2 1/2 hr drive without any traffic issues in Orlando (which would be a miracle in itself), I can't say that I'll miss that drive and I know my husband won't. I have enjoyed seeing the Tampa/St. Pete area on the months when we spend the night there due to appt. times

Dx 7/1/2016, IDC, Left, 4cm, Stage IIB, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 8/24/2016 Lumpectomy; Lymph node removal: Sentinel Chemotherapy 10/10/2016 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxol (paclitaxel)
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Feb 1, 2018 06:54PM aterry wrote:

I had my fourth injection on Wednesday and had the same reaction--just a slight, pinkish puffiness near the injection which went away after two hours. However, in the middle of the night, appr 12 hours after the shot, when I got up for the bathroom, I noticed that the site had gotten pinkish again with a little thickening under the skin and itchiness. The area is about 1 1/2" in diameter. It's 6:15pm Thursday and it's the same, though I assume it will fade away.

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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Mar 6, 2018 05:19PM pkville wrote:

Hi SuprSurvivr, I am receiving my treatment University of Kansas, in Kansas City, Kansas. Can you tell me more about the trial that you are in for the vaccine? I just started my first cycle of Xeloda, on Monday. But I am interested in whatever would help keep any reoccurrence from happening

Chemotherapy 9/17/2017 AC + T (Taxol) Surgery 1/24/2018 Lumpectomy: Left; Lymph node removal: Sentinel Dx IDC, Left, 2cm, Stage IIA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Radiation Therapy Breast, Lymph nodes
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Mar 6, 2018 06:55PM Connie1230 wrote:

after 6 injections, I am out of the trial because I have a malignant nodule in my lung.....

Dx 7/1/2016, IDC, Left, 4cm, Stage IIB, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 8/24/2016 Lumpectomy; Lymph node removal: Sentinel Chemotherapy 10/10/2016 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxol (paclitaxel)
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Mar 6, 2018 07:47PM SuprSurvivr wrote:

Connie1230, I’m SO sorry to hear about your recent diagnosis. Keep up the fight and try to find peace and joy in each day. I’ll keep you in my prayers. ✨🙏🏻✨


Pkville, Unfortunately, this particular immunotherapy vaccine clinical trial is closed. But, the KU Cancer Center is a great place to get info about other available trials. Be sure to let your oncologist know you are interested. My dr at KUCC is Dr Anne O’Dea, and she’s awesome.

As for Xeloda, pull up my profile and see the links to various Xeloda for triple negative blogs on this site. Be sure to get some good lotion to slather on your feet. Drink lots of water and have a good breakfast with your morning dose. Feel free to directly ask me any questions. Prayers for you too! ✨🙏🏻✨


I go up for monthly vaccine #5 this Thursday. So far the side effects have been minimal. My ANA blood work still shows some occasional high numbers, so I was referred to a rheumatologist. He says without other symptoms, the results are likely false positives. The urine tests they do before each vaccine to verify I’m not pregnant are showing some blood in my urine. So they have referred me to a urologist, who I’ll see after this upcoming apt

Every day is a gift! Dx 6/21/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 7/18/2016 AC + T (Taxol) Surgery 12/19/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 1/26/2017 Whole-breast: Breast, Lymph nodes Chemotherapy 5/6/2017 Xeloda (capecitabine) Chemotherapy 11/13/2017 CMF
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Mar 7, 2018 07:30PM VLH wrote:

Oh, Connie, I'm so sorry to hear of the lung nodule.

Lyn

Dx 5/20/2016, IDC, 2cm, Stage IIB, Grade 3, 0/3 nodes, ER-/PR-, HER2- (FISH) Surgery 7/14/2016 Lumpectomy: Left Dx 7/18/2016, DCIS, Left, Stage 0, Grade 3, 0/3 nodes Surgery 7/25/2016 Lumpectomy: Left Chemotherapy 10/10/2016 AC + T (Taxol) Radiation Therapy 9/5/2017 Whole-breast: Breast
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May 30, 2018 02:06PM rdeesides wrote:

Here is another Vaccine trial for TNBC NCT03012100 and here is the description:

Brief Summary:

This randomized phase II trial studies how well multi-epitope folate receptor alpha peptide vaccine, sargramostim, and cyclophosphamide work in treating patients with triple negative breast cancer. Vaccines made from a person's white blood cells mixed with tumor proteins may help the body build an effective immune response to kill tumor cells. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving multi-epitope folate receptor alpha peptide vaccine, sargramostim, and cyclophosphamide may work better in treating patients with triple negative breast cancer.

Below are contact info and locations.

Does anyone know anything about this trial? I haven't heard buzz about it. I am not a great match for the Keytruda trial and wondering if this would be better for me.

R

United States, ArizonaMayo Clinic in ArizonaRecruitingScottsdale, Arizona, United States, 85259 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Donald W. Northfelt United States, District of ColumbiaMedStar Georgetown University HospitalWithdrawnWashington, District of Columbia, United States, 20007 United States, FloridaMayo Clinic in FloridaRecruitingJacksonville, Florida, United States, 32224-9980 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Alvaro Moreno-Aspitia University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruitingMiami, Florida, United States, 33136 Contact: Onaidy T Torress 305-243-3379 OTorres@med.miami.edu Principal Investigator: Carmen J. Calfa United States, IllinoisUniversity of Chicago Comprehensive Cancer CenterNot yet recruitingChicago, Illinois, United States, 60637 Contact: Simona Olberkyte 773-702-4848 solberkyte@medicine.bsd.uchicago.edu Principal Investigator: Rita Nanda Carle Cancer Center NCI Community Oncology Research ProgramRecruitingUrbana, Illinois, United States, 61801 Contact: Christine M. Canfield 217-326-1881 christine.canfield@carle.com Principal Investigator: Kendrith M. Rowland United States, LouisianaOchsner Medical Center JeffersonRecruitingNew Orleans, Louisiana, United States, 70121 Contact: Socea A. May 504-842-2373 Socea.may@ochsner.org Principal Investigator: John T. Cole United States, MassachusettsDana-Farber Cancer InstituteNot yet recruitingBoston, Massachusetts, United States, 02215 Contact: Rachel Hepp 617-724-0878 etripp@mgh.harvard.edu Principal Investigator: Steven J. Isakoff United States, MinnesotaMayo ClinicRecruitingRochester, Minnesota, United States, 55905 Contact: Clinical Trials Referrals Office 855-776-0015 Principal Investigator: Kathryn J. Ruddy United States, VirginiaInova Fairfax HospitalRecruitingFalls Church, Virginia, United States, 22042 Contact: Parisa Saifollahi 703-720-5210 Parisa.Saifollahi@inova.org Principal Investigator: Mary J. Wilkinson United States, WisconsinMarshfield ClinicRecruitingMarshfield, Wisconsin, United States, 54449 Contact: Brenda Maronde 715-389-7542 maronde.brenda@marshfieldresearch.org Principal Investigator: Arlene A. Gayle

Sponsors and Collaborators

Academic and Community Cancer Research United

National Cancer Institute (NCI)

Investigators

Principal Investigator:Kathryn RuddyAcademic and Community Cancer Research United
Dx 6/24/2017, IDC: Medullary, Right, 2cm, Stage IIA, Grade 3, 0/2 nodes, ER-/PR-, HER2- (IHC) Dx 7/3/2017, IDC, Right, 1cm, Stage IIA, 0/2 nodes Chemotherapy 8/15/2017 AC Chemotherapy 10/11/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery 1/15/2018 Mastectomy: Right; Reconstruction (right): Tissue expander placement Radiation Therapy 2/21/2018 Whole-breast: Breast, Chest wall Chemotherapy 5/4/2018 Xeloda (capecitabine) Surgery 12/12/2018 Reconstruction (right): DIEP flap
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May 30, 2018 02:07PM rdeesides wrote:

Oh so sorry, the contact info and locations got all jumbled... Well, you can look it up on Clinicaltrials.gov if you are interested in it. ;-)


Dx 6/24/2017, IDC: Medullary, Right, 2cm, Stage IIA, Grade 3, 0/2 nodes, ER-/PR-, HER2- (IHC) Dx 7/3/2017, IDC, Right, 1cm, Stage IIA, 0/2 nodes Chemotherapy 8/15/2017 AC Chemotherapy 10/11/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery 1/15/2018 Mastectomy: Right; Reconstruction (right): Tissue expander placement Radiation Therapy 2/21/2018 Whole-breast: Breast, Chest wall Chemotherapy 5/4/2018 Xeloda (capecitabine) Surgery 12/12/2018 Reconstruction (right): DIEP flap
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Jun 26, 2018 08:21PM Jojobird wrote:

I was in the trial, at Texas Presbyterian Oncology.

Unfortunately I had a recurrence of TNBC. I was in the Low-dose arm.

I hope you all have better results.

Jojo

My blog: pinkstinks.blog/ Dx 3/2016, IDC, Right, 6cm+, Stage IIIC, Grade 3, 21/21 nodes, ER-/PR-, HER2- Surgery 4/18/2016 Lymph node removal: Underarm/Axillary; Mastectomy: Right Dx 4/2018, IDC, Right, 5cm, Stage IIB, Grade 3, ER-/PR-, HER2- Chemotherapy 4/27/2018 Taxotere (docetaxel), Xeloda (capecitabine) Chemotherapy AC + T (Taxol) Radiation Therapy Whole-breast: Breast, Lymph nodes
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Jun 26, 2018 09:31PM SuprSurvivr wrote:

I am so sorry to hear of your recurrence! I’ll keep you in my prayers. ✨🙏🏻

Every day is a gift! Dx 6/21/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 7/18/2016 AC + T (Taxol) Surgery 12/19/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 1/26/2017 Whole-breast: Breast, Lymph nodes Chemotherapy 5/6/2017 Xeloda (capecitabine) Chemotherapy 11/13/2017 CMF
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Jul 1, 2018 05:40PM Meggy wrote:

I'm really ignorant about these trials, but I have a question. Do they not also give the person the old school chemos? Like A/C and a Taxol or Taxotere? Do they only get the vaccine and another unusual chemo?

I do want to know if vaccines work but I worry about the ladies not getting what we know works for so many people.

It sounded like the chemo/vaccine was given before surgery. Once they realize that there is still cancer in the tumor/lymph nodes....is there no chance to go and get more established chemo? Is the person in the trail just expected to sit back and wait?

Sorry if I am really misunderstanding how these trails work.

Worried about all my sister.

See my 10 years out post regarding my extensive treatment. Triple Negative IDC Neoadjuvant chemo 2/08 of 4 dose dense A/C then 4 Taxol, Then Bilat in 6/08, then 2 more AC, then 4 Carboplatin/Taxotere. Then Radiation. Node Positive (5+). Dx 1/9/2008, IDC, Right, 2cm, Stage IIIA, Grade 3, ER-/PR-, HER2- Chemotherapy 2/2/2008 AC + T (Taxol) Surgery 5/10/2008 Mastectomy: Right; Prophylactic mastectomy: Left Chemotherapy 6/4/2008 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 9/10/2008 Breast, Lymph nodes Dx
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Jul 2, 2018 11:53AM rdeesides wrote:

Meggy, All the trials I have seen you also get traditional chemo. I don't remember the details of this particular trial but if I think you get neo-adjuvant chemo and then you get the vaccine after.

Dx 6/24/2017, IDC: Medullary, Right, 2cm, Stage IIA, Grade 3, 0/2 nodes, ER-/PR-, HER2- (IHC) Dx 7/3/2017, IDC, Right, 1cm, Stage IIA, 0/2 nodes Chemotherapy 8/15/2017 AC Chemotherapy 10/11/2017 Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery 1/15/2018 Mastectomy: Right; Reconstruction (right): Tissue expander placement Radiation Therapy 2/21/2018 Whole-breast: Breast, Chest wall Chemotherapy 5/4/2018 Xeloda (capecitabine) Surgery 12/12/2018 Reconstruction (right): DIEP flap
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Jul 29, 2018 04:10AM Meggy wrote:

Rdeesides, thanks for the information. It sounds like a win win if someone gets into those trials. I'm crossing my fingers that this leads to vaccines for all of us.

See my 10 years out post regarding my extensive treatment. Triple Negative IDC Neoadjuvant chemo 2/08 of 4 dose dense A/C then 4 Taxol, Then Bilat in 6/08, then 2 more AC, then 4 Carboplatin/Taxotere. Then Radiation. Node Positive (5+). Dx 1/9/2008, IDC, Right, 2cm, Stage IIIA, Grade 3, ER-/PR-, HER2- Chemotherapy 2/2/2008 AC + T (Taxol) Surgery 5/10/2008 Mastectomy: Right; Prophylactic mastectomy: Left Chemotherapy 6/4/2008 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 9/10/2008 Breast, Lymph nodes Dx
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Nov 6, 2018 02:48PM aterry wrote:

I'm in the Tapimmune Folate Receptor trial and I had the first booster injection last Wednesday (Hallowee, Oct 31st). This time they gave me the injection in the right arm, 3" below my right shoulder. During the active part of the trial all 6 injections were midway up my right forearm. I have no idea what the switch was about. The only other change was that they didn't take a urine sample to check protein levels which they did last winter/spring. Again, I have no idea why there was this small change. The clinical trial coordinator said there has been no news about preliminary results. I thought the next phase was already in the works and I would think that'd they'd need to have some results from our phase first since our phase was intended to determine the dosing protocol. Anyway, the process was simple. I had a very slight reaction at the injection site--a little raised and pinkish and later a little itchy but by the next day the itchiness was gone and the raised area never got bigger than a dime; receded completely after 5 days.

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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Jan 3, 2019 08:37PM aterry wrote:

Below are excerpts from a news release made by the company sponsoring the Tapimmune trial:

"Marker Therapeutics also reported initial findings from its interim analysis of its dose-finding study (Study FRV-002) in patients with triple negative breast cancer, using TPIV200 as a maintenance therapy for patients in remission following first-line therapy. The four-arm study included low and high dose TPIV200 with or without cyclophosphamide.

Of 27 patients evaluated to date for immunogenicity, 26 showed significant immune response to the vaccine treatment. Of 80 patients treated at 11 clinical sites, 11 have shown disease progression to date following treatment with TPIV200."

Finally, our clinical sites have been very supportive of our Phase II vaccine studies in ovarian and breast cancer, and their rapid enrollment is a credit to our Principal Investigators and clinical investigative sites, as well as our clinical operations team. We are pleased with the progress in building our clinical development infrastructure and believe we can leverage that experience to drive our upcoming MultiTAA T cell studies efficiently."

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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Jan 17, 2019 03:45AM Deedi wrote:

a terry I am interested in the vaccine trial. I just received news that my cancer has spread to my mediastinal nodes. That may be consider stage 4. Will the vaccine trial accept Local reoccurrence or stage 4 tnbc? This is my first post so I am hoping I am doing this correctly


Dx 10/5/2016, IDC, Left, 6cm+, Stage IIIA, Grade 2, 5/16 nodes, ER+/PR+, HER2- Surgery 3/13/2017 Mastectomy Chemotherapy 7/3/2017 Xeloda (capecitabine) Targeted Therapy 7/8/2017 Herceptin (trastuzumab) Dx 12/4/2018, IDC, Both breasts, Stage IV, metastasized to lungs/other, Grade 2, ER-/PR-, HER2- Immunotherapy 1/24/2019 Chemotherapy AC + T (Taxol)
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May 4, 2019 03:45PM aterry wrote:

Deedi, I'm so sorry I didn't see your post. I don't visit the forum as often as I did when I was under active treatment. Have you gotten information that has been helpful?

I had my second booster injection as part of the Tapimmune Folate Receptor trial. This time the injection was in the thigh. They move the injection site around--I have no idea why. I'm in the low dose arm of the trial. Some patients get 3 injections. At the injection site I have slight thickening in a pinkish circle which grew to about 2" in diameter and has now (3rd day) reduced to 1" and is almost faded. There was slight itching. Other than that there are no side effects.

Tapimmune was purchased by Marker Pharmaceuticals. I don't know whether anyone is posting under that title--guess I should do a search ;-)

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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May 9, 2019 09:07PM aterry wrote:

Here's an update from Marker Therapeutics* on the Folate Receptor vaccine trial:

"The Company reported initial findings from its dose-finding, four-arm Phase 2 clinical trial in triple negative breast cancer, including low- and high-dose TPIV200 with or without cyclophosphamide. Of 27 patients evaluated for immunogenicity, 26 showed significant immune response to the vaccine treatment. Of 80 patients treated at 11 clinical sites, 14 have shown disease progression, as of April 30, 2019, following treatment with TPIV200."

*Tapimmune was purchased by Marker

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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May 10, 2019 12:24PM SuprSurvivr wrote:

Thanks for the updates! My last two boosters have been in my upper arm vs the lower forearm for the earlier shots. I’ve had very little reaction - just some inject site itchiness for a few days.

Every day is a gift! Dx 6/21/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 7/18/2016 AC + T (Taxol) Surgery 12/19/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 1/26/2017 Whole-breast: Breast, Lymph nodes Chemotherapy 5/6/2017 Xeloda (capecitabine) Chemotherapy 11/13/2017 CMF
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May 20, 2019 08:58PM aterry wrote:

I just noticed in My Chart that a test result was posted for something called ANTI-TSH AUTOANTIBODY. I don't think I ever had that test before, or if I had it, as part of all the tubes of blood they take, I didn't get the results. So in this case the result was "negative" which is the normal reading. I have no idea what a TSH antibody is, if that's what we're talking about. SuprSurvivr, did you get that test as part of your blood work?

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)
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May 20, 2019 10:49PM - edited May 20, 2019 11:12PM by SuprSurvivr

Aterry - I haven’t had the that test. When Iwent back to check older test results - I do have some TSH results about every two months during the monthly shot phase. My results have a number assigned and just say “TSH” with an “Mcu/ml” with a range of 0.35 to 5.0. Mine have generally fallen in the 1.5 range. Last time the test was run was 5-18.

Every day is a gift! Dx 6/21/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 7/18/2016 AC + T (Taxol) Surgery 12/19/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 1/26/2017 Whole-breast: Breast, Lymph nodes Chemotherapy 5/6/2017 Xeloda (capecitabine) Chemotherapy 11/13/2017 CMF
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May 20, 2019 10:52PM SuprSurvivr wrote:

Aterry - just did a google search on that test - https://www.ncbi.nlm.nih.gov/m/pubmed/10874533/


Every day is a gift! Dx 6/21/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 7/18/2016 AC + T (Taxol) Surgery 12/19/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 1/26/2017 Whole-breast: Breast, Lymph nodes Chemotherapy 5/6/2017 Xeloda (capecitabine) Chemotherapy 11/13/2017 CMF
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Nov 14, 2019 02:11PM aterry wrote:

This was reported by Marker Therapeutics, yesterday:. (TapImmune was purchased--I guess--by Marker.)

  • "Based on a preliminary analysis of 34 patients enrolled in the triple negative breast cancer trial, 31 patients showed meaningful immune response to vaccine treatment;
  • Of 80 patients treated at 11 clinical sites, 14 have shown disease progression, as of September 30, 2019, following treatment with TPIV200."
This seems to be good newsbecause there are no further progressions since the last report which was in May, although the ratio of patients showing meaningful immune response is a little lower.

I had another injection, yesterday. This was in my upper arm. I have the same very minimal reactions as the other times. Slightly pink, slight swelling, slight itching. They only took 2 tubes of blood this time.

Thanks for posting that link, SuprSurvivr.


Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/23/2017 Targeted Therapy Targeted Therapy Chemotherapy AC + T (Taxol)

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