Melatonin and TNBC
This was published Jan 6, 2019. I hav been taking Melatonin for over 5 or 6 years (10 mg). I read somewhere that it killed or prevented metastasis in the lab or something like that.
Pretty exciting evidence for it helping. If I had known about this article 7 years ago I would have started taking it then and I would have taken a heck of a lot more!
Hope this helps someone...
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For TNBC both melatonin and Metformin are very good complimentary treatments. My Naturopathic physisican suggests 20 mg of Melatonin at roughly the same time each night. I do 1000 mg (500am, 500 pm) of Metformin too.
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Dear Santa (I always wanted to say that!!) - I think the Metformin really depends on the individual. My GP wrote me a script for 500 mg a day (250 twice daily). I never moved off of 250 mg once daily for over a year. I was hungry all the time. Sometimes so hungry it was like I was having a panic attack for food (light headed, etc.).
I took myself off it. I was a normal weight back then now I have gained a few lbs. maybe it would work better for me now.
What I think has worked incredible with me with no side effects is Simvastatin. I had high cholesterol for several years (4 at least - not so good for TNBC survivors) but not so high so that my doctor was worried about a heart attack. I took 1 months worth of pills (30 pills of 10mg) over 3 months and had normal numbers for the first time in over 5 years. I also drink a ton of green tea (which impacts different statins indifferent ways) which may have increased the amount of simvastatin that I was absorbing. Lots of interesting stuff with Simvastatin, it crosses the blood brain barrier, it’s good with triple negative breast cancers and seems to have immune effects.
https://www.sciencedaily.com/releases/2019/05/190510095059.htm
I did not know about a lot of this stuff when I started taking it. My thinking was I had to eat low fat and keep my cholesterol in check. I am eating more healthier fat now (at least 1 tbsp of olive oil a day). It will be interesting to see what my lipid profile is next month when I get it retested.
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Statins seem to have anti-tumor effects too... If you look at the book How To Starve Cancer she talks about it... There is an alternative oncology clinic doing a course of repurposed drugs in a combo for BC... a statin + metformin + mebendazole (pinworm drug) + doxycycline... between the 4 prongs, a lot of cancer stem cell replication pathways are attacked.
Interesting what you say about hunger, I have been hungrier too since getting on metformin, did not realize it was a SE because I have been recovering post treatment in general... but anyway, I want the metformin benefits. Ironically, I have found intermittent fasting has brought my hunger level down.
I am NED after neoadjuvant chemo but have been thinking that now might be a good time to ask my MO about adding a statin, and to do a course of doxycycline & mebendazole, before there is something larger to fight... May I can convince him to let me do 60 or 90 days of it. I
have pushed that poor man to his breaking point.... he's Mr. Double Blind.... but he has been a trouper to hang in with me on all the complimentary therapies i have pursued. I keep thinking, if it doesn't hurt and it might help, then I want it....
Other compounds I am interested in are berberine, DHEA, chloroquine, dipyridamole... I am already on curcumin, EGCG, quercetin and I have been doing hyperbaric oxygen + Vitamin C IV once per week. I am hoping a full court press during first 3 year prime recurrence window will help me....
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