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Topic: Melatonin and TNBC

Forum: Triple-Negative Breast Cancer —

Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: May 29, 2019 07:38PM - edited May 29, 2019 07:38PM by Kayrem

Kayrem wrote:

This was published Jan 6, 2019. I hav been taking Melatonin for over 5 or 6 years (10 mg). I read somewhere that it killed or prevented metastasis in the lab or something like that.

http://www.alliedacademies.org/articles/a-phase2-study-of-highdose-pineal-antitumor-hormone-melatonin-as-an-adjuvant-therapy-in-triple-negative-breast-cancer.pdf

Pretty exciting evidence for it helping. If I had known about this article 7 years ago I would have started taking it then and I would have taken a heck of a lot more!

Hope this helps someone...

Dx 6/13/2011, IDC, 2cm, Stage IIIA, Grade 3, 4/11 nodes, ER-/PR-, HER2- Surgery 6/29/2011 Lumpectomy: Right Chemotherapy 9/14/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxol (paclitaxel) Radiation Therapy 2/20/2012 Breast, Lymph nodes Surgery 3/13/2013 Prophylactic mastectomy: Left, Right Surgery 5/20/2013 Prophylactic ovary removal
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May 30, 2019 09:29AM santabarbarian wrote:

For TNBC both melatonin and Metformin are very good complimentary treatments. My Naturopathic physisican suggests 20 mg of Melatonin at roughly the same time each night. I do 1000 mg (500am, 500 pm) of Metformin too.

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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May 30, 2019 10:53AM Kayrem wrote:

Dear Santa (I always wanted to say that!!) - I think the Metformin really depends on the individual. My GP wrote me a script for 500 mg a day (250 twice daily). I never moved off of 250 mg once daily for over a year. I was hungry all the time. Sometimes so hungry it was like I was having a panic attack for food (light headed, etc.).

I took myself off it. I was a normal weight back then now I have gained a few lbs. maybe it would work better for me now.

What I think has worked incredible with me with no side effects is Simvastatin. I had high cholesterol for several years (4 at least - not so good for TNBC survivors) but not so high so that my doctor was worried about a heart attack. I took 1 months worth of pills (30 pills of 10mg) over 3 months and had normal numbers for the first time in over 5 years. I also drink a ton of green tea (which impacts different statins indifferent ways) which may have increased the amount of simvastatin that I was absorbing. Lots of interesting stuff with Simvastatin, it crosses the blood brain barrier, it’s good with triple negative breast cancers and seems to have immune effects.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=12284&path%5B%5D=38897

https://www.sciencedaily.com/releases/2019/05/190510095059.htm

I did not know about a lot of this stuff when I started taking it. My thinking was I had to eat low fat and keep my cholesterol in check. I am eating more healthier fat now (at least 1 tbsp of olive oil a day). It will be interesting to see what my lipid profile is next month when I get it retested.

Dx 6/13/2011, IDC, 2cm, Stage IIIA, Grade 3, 4/11 nodes, ER-/PR-, HER2- Surgery 6/29/2011 Lumpectomy: Right Chemotherapy 9/14/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxol (paclitaxel) Radiation Therapy 2/20/2012 Breast, Lymph nodes Surgery 3/13/2013 Prophylactic mastectomy: Left, Right Surgery 5/20/2013 Prophylactic ovary removal
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May 30, 2019 11:33AM santabarbarian wrote:

Statins seem to have anti-tumor effects too... If you look at the book How To Starve Cancer she talks about it... There is an alternative oncology clinic doing a course of repurposed drugs in a combo for BC... a statin + metformin + mebendazole (pinworm drug) + doxycycline... between the 4 prongs, a lot of cancer stem cell replication pathways are attacked.

Interesting what you say about hunger, I have been hungrier too since getting on metformin, did not realize it was a SE because I have been recovering post treatment in general... but anyway, I want the metformin benefits. Ironically, I have found intermittent fasting has brought my hunger level down.

I am NED after neoadjuvant chemo but have been thinking that now might be a good time to ask my MO about adding a statin, and to do a course of doxycycline & mebendazole, before there is something larger to fight... May I can convince him to let me do 60 or 90 days of it. I

have pushed that poor man to his breaking point.... he's Mr. Double Blind.... but he has been a trouper to hang in with me on all the complimentary therapies i have pursued. I keep thinking, if it doesn't hurt and it might help, then I want it....

Other compounds I am interested in are berberine, DHEA, chloroquine, dipyridamole... I am already on curcumin, EGCG, quercetin and I have been doing hyperbaric oxygen + Vitamin C IV once per week. I am hoping a full court press during first 3 year prime recurrence window will help me....

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes

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