Sep 3, 2020 02:28PM anornurse wrote:

My name is Sharon. I was diagnosed with triple negative breast cancer in my left breast, negative nodes in 2011. In 2019, I was diagnosed with metastatic triple negative breast cancer in my brain, lungs, and thoracic spine. I have been on Trodelvy since May 2020. I have had 11 doses. After the 8th dose, I had a cat scan of my lungs. Both lesions shrunk considerably for the first time. My white count has been normal to low normal and diarrhea has been occasional and treated with immodium with relief. The lesions in my brain were treated with the cyber knife with good results. Any questions? Feel free to ask. I live in New Jersey.

Sep 6, 2020 01:15PM Wanderingneedle wrote:

Hello, I started Trodelvy last week. Right now fatigue is my biggest complaint. I’ve had a few gastric issues but more nausea than anything. And food doesn’t sound good! Since turning TNBC nothing has worked, but I have a new doctor and she’s terrific

Sep 8, 2020 07:05PM Wanderingneedle wrote:

Hi, Sharon,

I had my second dose today. My red blood cells are low, measuring at 2.76 (3.9-5.2 normal range) before chemo. Do yours tank, and if they do what do you and/or your doctor do about it? Iron pills 🥴? Diet changes? Other supplements? I’d like to find things that I can do without causing more issues before I see my doctor again in two weeks. Good to hear you are tolerating it so well. I hope I stabilize and do the same as I feel a response after one dose. Amazing!

Sep 9, 2020 01:32PM - edited Sep 9, 2020 01:35PM by texaslaughter

Hello! I came on to start a thread because I didnt think one existed, glad this one exists. I too am TNBC metastatic to the bones and liver. I was originally diagnosed in 2015, had a complete pathologic response then almost 5 years later it came back to my bones and liver in Nov 2019. My first treatment worked for 5 months then I quickly blew through Xeloda and Abraxane - like within the first round. My Onc quickly moved me so I started Trodelvy August 7th after becoming critical as my liver got bad seemingly overnight. My tumors seemed to be doubling and I was in crisis mode. My Onc didn't think I would make it through the weekend, and this was it for me. My one last shot. SO I have had 4 treatments in 10 months with 2 failing. The first infusion of Trodelvy stabilized me. My liver enzymes were of course off the charts, and 5 days later from 1st infusion I responded (they didn't think I would make it through the treatments because my counts were horrible as well). My liver numbers increased less than they had been and luckily I was still here. I had the second infusion 10 days later versus on the 8th to allow for blood, platelet, and WBC transfusions/injections to increase enough for 2nd. We were in crisis mode and my Dr took chances I asked of her because really what was there to lose? I took the second infusion and I had no increase in liver enzymes. My onc looked at me in the room shocked because they had been steadily increasing. I had my third infusion, and had a slight decrease in enzymes. At that point I was 1.5 cycles in - I hadnt been able to finish a full cycle in months!. Yesterday I went in for the 4th infusion to complete the 2nd cycle and my enzymes were down 37-40%. This drug is amazing. Has literally saved my life. I still have a long road to go because of the damage from almost going to liver failure but each day I am getting better and better. I can't wait until I have a few more cycles of these. Because of how quickly and well I have responded we are doing a scan next week. This is the first time I don't dread the scan. But they say with this drug if it works, it really works. I dont know for how long but its at least given me more time and hope. I know based on the study that a number had partial responses, and if I read it right thats 50% reduction in tumors, ~3% had complete responses, elimination of tumors all together, with some even still going strong 30+ months It gives me hope I didnt have. As the first targeted treatment for us MTNBC, I am so hopeful. I wanted to share this because this is already a horrid disease and there isn't a lot of information about this new drug. It does pave the way for more options.

Sep 9, 2020 04:35PM anornurse wrote:

Omg! What you have been through and back again to the living! Don't give up hope! You have a purpose to keep us informed of your progress. I look forward to hearing from you really soon! Sharon