Topic: Sacituzumab Govitecan (Trodelvy)

Forum: Triple-Negative Breast Cancer — Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: May 21, 2020 12:30PM

Posted on: May 21, 2020 12:30PM

Erich wrote:

Hello everyone. I was wondering if anyone(s) could share any experiences they have had using sacituzumab govitecan (Trodelvy) either in a clinical trial or as recently approved by the FDA.

We are trying to determine if it's the best plan of action for my wife at this time. There are 2 key things we are trying to determine.


1) How bad are the side effects (I've read everything from "terrible" to "manageable")?

2) Has it helped with your brain metastases or other CNS metastases? This is a tough question, I know. There is next to zero clinical data on it so far. Just trying to get any anecdotal evidence I can at this point.


Thank you all for any information on this! :)



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Apr 13, 2022 08:38PM cookie54 wrote:

Sorry to hear you didn't get the results that you were hoping for. Glad to hear your MO reached out to an associate for another opinion. It's nice to have an extra set of eyes to review your treatment plan. Sending good vibes that with these next 2 cycles you will have improvement. Best wishes.

Dx 8/15/2016, IDC, Right, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Surgery 9/14/2016 Mastectomy; Reconstruction (Left): Saline implant; Reconstruction (Right): Saline implant Chemotherapy 10/14/2016 AC Dx 6/2020, IDC, Right, Stage IIIC, Grade 3, 5/8 nodes, ER-/PR-, HER2- Chemotherapy 6/29/2020 Carboplatin (Paraplatin), Gemzar (gemcitabine) Surgery 10/19/2020 Lymph node removal; Lymph node removal (Right) Radiation Therapy 11/23/2020 Whole breast: Breast, Lymph nodes, Chest wall Chemotherapy Xeloda (capecitabine)
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Apr 18, 2022 06:26PM hollyli1202 wrote:

Well, I am moving on from Trodelvy. After 3 cycles, my CT scans came back as growth. I have more spots on my pleural lining. The spot seen on my Jan scan on my pluera grew in size. The lymph nodes in my abdomen have remained the same more or less. They grew one way, but shrunk in the other measurement - except for one lymph node and that one grew. There a small lesion now on my T6. And then there are multiple lesions on my liver. The biggest being 2.2 x 2.2 cm that weren't there before.. or grew. Not sure. I've always had lesions on my liver, but they hadn't grown since the beginning of time. However, on the Jan scan they did say there were little hypodensities too small to measure. So maybe those are the lesions.

My oncologist is taking me off Trodelvy immediately (my next infusion was for tomorrow 4/19). He's ordered a liver biopsy now that the cancer is in an area that can be biopsied. He's putting me on doxil. Argg! But we did talk about some other treatments for down the road. While it was not what I wanted to hear, I did have a feeling Trodelvy was not working for me since my CEA numbers tripled and my other tumor markers went up past the "normal" zone. I am disappointed. Not mad, just disappointed. I worked so hard to get the chemo approved through my insurance company AND I finally am pronouncing sacituzumab correctly! HA.

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Apr 19, 2022 07:28AM nicolerod wrote:

Holly so sorry to hear that I hope your next treatment works really well.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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Apr 19, 2022 05:42PM hollyli1202 wrote:

Nicole, how was doxil? I think that is the next treatment path for me. I have a liver biopsy scheduled for Thursday. Keep me in your thoughts.

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Apr 19, 2022 06:06PM nicolerod wrote:

Holly doxil was easy peasy..it didn't work for me..shame..but nothing really has yet.... I hope it works well for you. I had no side effects.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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May 12, 2022 12:06PM - edited May 12, 2022 03:53PM by denny10

Today was my first round of Trodlevy. I was given a Fomatidine pill, to prevent gastric problems. Paracetomol tablets, to stop back pain. A Loratidine tablet to prevent rashes. Then intravenous saline, then dexamethasone, then Aloxi [anti emetic] and finally Trodlevy, administered over 3 hours. The nurse stayed with me for the first 15 minutes. I was observed every half hour to see how I was doing , then more saline for 45 minutes before I was allowed home with Omaprazole , dexamethasone and Loratadine. Does this sound like your protocol ? It was a long day!

After my cancer switched from hr+ to triple negative and I progressed on Abraxane, then Halaven. I was found to be a suitable canditate for Trodlevy . I am in the UK and the NHS does not fund Trodlevy yet ,other than in trials. We pay for private health insurance [ it was part of my husbands employment package, but when he retired we chose to pay ourselves so I could remain with the same Oncology team ]. I feel fortunate to be able to try this drug.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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May 12, 2022 12:27PM moth wrote:

hi denny, glad you were able to access it even tho NICE is still messing with supplying it.

My premeds are ondansetron + 20mg iv dexamethasone. Then I take ondansetron again that evening and have 2 days of 4mg oral dex. I've seen people have a lot of different premed protocols but yours seems to cover all the bases.

Hope you're having a good day post infusion :)

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Radiation Therapy 3/3/2021 External Local Metastases 3/3/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy)
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May 13, 2022 05:26PM denny10 wrote:

Thanks for your input, moth. I did not sleep much last night and have a bright red face from steroids. I only had 8mg of iv dex , I would be climbing walls on 20mgs. 8mgs for me for 2 more days, when I know I will be tired but wired. If otherwise I continue to feel ok, I will be in 'negotiations' with oncologist to drop the dose next infusion day . I am fascinated how we all react differently to meds.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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May 14, 2022 10:23AM nicolerod wrote:

Denny...sorry but to be clear...arent you the person that has had breast cancer for like over 10 or 15 years stage 4 and were doing well bc you were triple positive??? If so ..bummer that you receptor flipped... sorry about that. I did receptor flip too but I was unfortunately not triple pos.

Hope you do well on Trodelvy...

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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May 15, 2022 04:50AM denny10 wrote:

hi nicolerod, I was initially diagnosed 1907 hr+, mets 2013 hr+ ,then flipped to triple negative last year. I will try and update my info. when it becomes easier to use this site ,but have always had trouble.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)

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