Topic: Sacituzumab Govitecan (Trodelvy)

Forum: Triple-Negative Breast Cancer — Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: May 21, 2020 12:30PM

Posted on: May 21, 2020 12:30PM

Erich wrote:

Hello everyone. I was wondering if anyone(s) could share any experiences they have had using sacituzumab govitecan (Trodelvy) either in a clinical trial or as recently approved by the FDA.

We are trying to determine if it's the best plan of action for my wife at this time. There are 2 key things we are trying to determine.


1) How bad are the side effects (I've read everything from "terrible" to "manageable")?

2) Has it helped with your brain metastases or other CNS metastases? This is a tough question, I know. There is next to zero clinical data on it so far. Just trying to get any anecdotal evidence I can at this point.


Thank you all for any information on this! :)



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Sep 15, 2020 02:46PM anornurse wrote:

Texaslaghter, Good luck with your scan, please keep us posted! I also have insurance and it is covered! Sharon


Moth, May you soon be covered! Sharon



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Sep 20, 2020 12:33PM texaslaughter wrote:

I follow Trodelvy closely and not only was there a big sale of it’s company that created it recently but below is an article on the recent phase 3 results. I thought I’d share.

https://www.globenewswire.com/news-release/2020/09/19/2096160/0/en/Trodelvy-Significantly-Extends-Survival-in-Phase-3-ASCENT-Study-of-Metastatic-Triple-Negative-Breast-Cancer.html

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Sep 20, 2020 01:21PM anornurse wrote:

Shay, I follow trodelvy, but you are really good! They were bought by Gilead, so I told my husband to follow Immunomedics and Gilead. I also copied the article. I'm going to give it to my oncologist this week when I get my treatment, which will be #13. This is such a wonder drug, how lucky are we! Thank you so much for letting me know! Keep the faith! Sharon

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Sep 21, 2020 11:35AM handeadiguzel wrote:

Hi everyone,

My mother has TNBC with mets to liver. We don't live in US. I was wondering if anyone was able to obtain trodelvy outside of US ?

Thank you :)

I am a caregiver. Diagnosis belongs to my mother. Dx 4/2018, Right, 6cm+, Stage IV, metastasized to liver, ER-/PR-, HER2- Chemotherapy Adriamycin (doxorubicin), Carboplatin (Paraplatin), Gemzar (gemcitabine), Halaven (eribulin), Navelbine (vinorelbine), Taxol (paclitaxel) Surgery Mastectomy: Right
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Sep 21, 2020 08:36PM texaslaughter wrote:


I’m sorry to hear about your Mom and that she is a part of this group none of us want to be. I’m not sure where it is available because of its limited approval but do know that not many countries cover it yet since it just finished its clinical trial. The best action is to talk to your oncologist to see if it’s available where you are. Your mom must have also failed 2 prior treatments to be eligible for it but they are looking at it as a first line treatment in the future. Wishing you and your mom all the best.

Sharon - I’m pretty obsessed with this treatment since it’s the only thing that saved my life. I did have a parp (lynparza) work for about 5 months but after failing 2 back to back quickly I was desperate. With the new data out on this drug and my current response I am so very hopeful about future treatments.

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Sep 21, 2020 09:20PM anornurse wrote:

Talk to Moth, she is from Canada and is knowledgable about trodelvy. Also you may want to contact the company who manufactures trodelvy. It's called Immunomedics. They will be bought out by Gilead. Both are American companies. Good luck to you and your Mom

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Sep 21, 2020 09:32PM anornurse wrote:

Shay, I too believe trodelvy is a major break through for tnbc. You are doing so well, you are a miracle and a great hope for other women with the same diagnosis. You wrote that the cancer is in your liver and bones. May I ask which bones? I would think the trodelvy would work in the liver more quickly because it's soft tissue. Bone is harder and may take a little longer. On a lighter note ,one of the good things about no hair, I get to wear the cutest earrings (my ears are pierced) and they are very noticeable! Sharon

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Sep 26, 2020 02:18AM texaslaughter wrote:

Hello all - just started cycle 3 today and decided to post my progress. The steroids have me up late tonight! One of my liver enzymes - ALT - is normal at 35 from 287. My bilirubin went from 7.2 at start of treatment to 2.1 (my eyes were so yellow! They aren’t now) and my AST went from 267 to 90. I’ve only been on the drug for 45 days and it not only stabilized me but brought me from liver failure. I rapidly had developed ascites and had to get it drained in August which contributed to digestive issues and I lost over 20 pounds. The ascites is practically nonexistent, I had 4 liters drained in august after an almost 2 month build up - did another Drain this week to get ahead of it and was minimal. I was jaundiced, swollen and unable to walk when I started Trodelvy. I now can walk short distances and have started to put on weight; the swelling is gone as well. We expect the other enzymes to follow suit, and from my scan last week my tumors shrunk to where they were in my July scan. I have had a ct scan monthly. This all within 45 days and 2 cycles. As someone who was hopeless and told this was my only shot because of how aggressive it had become, I want this to give hope to anyone out there. I’m still pushing but even when it feels like there is nothing left, things can change just as quickly. It’s been hard, but if you are a believer - continue to be so.

Shay/texaslaughter

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Sep 28, 2020 04:37PM moth wrote:

handeadiguzel, I agree with writing to the manufacturer directly and inquiring about the closest location for a trial. I know the drug now has a waiver in Europe so it can be used for breast cancer treatment but I don't know how easy it is to obtain it or how much it costs there

Immunomedics GmbH

Tel. +1 8622603582
E-mail: dwhiteley@immunomedics.com

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Radiation Therapy 3/3/2021 External Local Metastases 3/3/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy)
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Sep 28, 2020 04:38PM moth wrote:

Shay/texaslaughter - SOOOOOOO happy for you!!! you go, girl!

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Radiation Therapy 3/3/2021 External Local Metastases 3/3/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy)

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