Topic: Sacituzumab Govitecan (Trodelvy)

Apr 21, 2021 09:43AM Grannax2 wrote:

Thanks DoubleBloom. I will read all the posts.

Apr 27, 2021 09:40AM S3K5 wrote:

moth, the results from ASCENT trial looks promising. Are you on this drug? If so, what's your experience on this so far?

Apr 27, 2021 10:23AM moth wrote:

S3K5, no I'm not on Trodelvy atm. It's not even approved in Canada yet. We're hoping it will be soon. I'm still on first line atezolizumab + taxane right now.

Apr 30, 2021 03:44PM - edited Apr 30, 2021 03:45PM by jc73

Hi everyone, my mom just started her 3rd cycle of trodelvy today. She has small mets in both lungs. She had a CT scan yesterday that showed stable. For those of you who had regression, how many cycles did you have before you saw the regression? I'm thankful for stable, but still hoping for regression on the next scan.

Apr 30, 2021 06:06PM Wanderingneedle wrote:

jc73, I had 3 full cycles before my first scan which should showed regression. We lowered the dose and my next scan after 4 more cycles showed stability.

Apr 30, 2021 09:07PM jc73 wrote:

DoubleBloom, that’s pretty amazing that you reached NED. I will be praying for you to get back there again. Trodelvy worked so well the first time I’m sure it will kick it in the butt again!

Wanderingneedle, may I ask what the reasoning was for lowering the dose? Side effects? I’ll be praying that trodelvy gets your mets back under control after your short break.

May 1, 2021 11:48AM - edited May 1, 2021 11:49AM by DoubleBloom

I receive IV Emend as a premed which helps incredibly with the nausea. It is also available as a tri-pack which you can take at home.

Have any of you had mouth sores? My gums are raw and inflamed. My doc px a steroid mouthwash which seems to be helping.

Hope you all are having a nice weekend.

May 4, 2021 08:01AM DoubleBloom wrote:

SKR5 Would it help to ask your doctor (instead of the nurse) while explaining how zofran doesn't help and you are suffering? Can you request Emend?

May 12, 2021 04:51PM theresa45 wrote:

S3K5 - Emend helped me a lot with the nausea when I was on Enhertu and I continue to use it as a premed infusion with Trodelvy. I'm having my second infusion of my 3rd cycle of Trodelvy (so tomorrow will be my 6th infusion). My first scan on Trodelvy will be at the end of next week, so after 3 full cycles (~10 weeks because I took one extra week off between cycle 1 and cycle 2 to get my second Moderna vaccine). I hope that Trodelvy is effective for all of us!!!!

May 13, 2021 08:46AM DoubleBloom wrote:

I find that Troodelvy makes my body tremble. Arms, legs, torso. Anyone else?

May 31, 2021 11:54AM theresa45 wrote:

Hi All,

Unfortunately my first CT scan after 3 cycles of Trodelvy showed progression in the liver and lungs, so I just switched to Halaven(aka eribulin). Prior to starting Trodelvy, I was on the DESTINY04 trial of Enhertu for HER2 low patients which worked for about a year. Enhertu and Trodelvy have different targets but deliver a similar chemo agent. So, I knew that there was a risk that it would nor work. A couple of hormone positive patients in my metastatic breast cancer group have a had significant and relatively long lasting responses to Trodelvy.

Wishing everyone the very best!

Theresa

May 31, 2021 01:50PM DoubleBloom wrote:

Theresa45,

I'm saddened to hear that your three cycles didn't work. Wishing you the best with your new treatment plan.

Jun 2, 2021 02:22PM DoubleBloom wrote:

anornurse.

Sorry to hear that Trodelvy stopped working yet am happy that you have other options. There are so many effective drugs out there. How long were you on Trodelvy? Has your doc mentioned how long he / she wants you to stay on the new meds?

Jun 2, 2021 09:07PM AmyQ wrote:

I am new to this board. I'm on my fifth round of Trodelvy. It's dropped my tumor markers significantly. What's interesting is I too have noted hand trembling in both hands. I dismissed it to the tumor in my spine which received 10 rounds of radiation. Other than 1 week of diarrhea, I have had no other side-effects. Well, I guess I am wrong. The hand trembling appears to be a side-effect. Is there anything that can be done?

I have a PET/CT scan scheduled for mid-July. Thank you.

AmyQ

Jun 3, 2021 04:59PM Elligtr wrote:

Hello everyone, I'm new to this topic and the forum in general, I've learned so much. I just came back from MO office and he says Trodelvy now--there are numerous liver tumors on my last CT after being stable. Good to know about the fact its a long infusion and to be proactive with the GI issues. I was otherwise for 6 months on Tecentriq/Abraxane. No major side effects although he said some people do have quite a few with the immunotherapy! So reason for writing now, is he is recommending Trodelvy and I'm worried about these neurological side effects I'm reading about and to be prepared for nausea. I know everyone is different, but I also have had WBR and they are still monitoring a few spots to see if active or just immunotherapy effect. Sad to see the T/Abr. combo go, it was tolerable and was keeping bones and lungs very stable. He says Trodelvy is a breakthrough drug and would be next for TNBC. However, I'm seeing that its not all for TNBC and not necessarily super long lasting, I thought I was at the end of the line here, I did ask about the Cisplatin and he said he would prefer Trodelvy and that the platinum agents are very tough on people, but it is a choice if I want to go that route too. It almost sounds like he was selling me Trodelvy but how long of a run do you get on this, previously he thought one could be on Tecentriq for a very long time. He would like a liver biopsy, but I decided to defer for now, sounds a bit painful and potential for lung puncture, of which I have had 2 already (lung collapse) when draining fluid for the Pleural effusion last year. I'm one of those tricky subtypes, where some biopsies have said ER +, but others so low that I'm practically TNBC, hence I qualified for the Tecentriq with a 5% PDL1 , I did not do well on the CDK (Verzenio) or Xeloda--lasted less than 4 or 5 months on these with painful feet and lots of diarrhea. I guess there's a chance of finding HER 2 in having a biopsy although I doubt after so many tests, FISH included. What other options have you heard about? In Best birds guide, there's all kinds of radiation type options for the liver but he said blanket "no" to all of those.

I'm sorry to hear about the tremors, I would think the brain treatments would have something to do with that, but seems all these chemo drugs have some sort of nerve damage, particularly the Taxanes, which Abraxane is one of those and prone to neuropathy. Seeing a good neurologist probably a great idea. I recently found out there is also a type of doctor "NeuroOncologist" that deals with potential treatments for brain mets and related neurological issues, which I was surprised that he mentioned Avastin as an option now used in other cancer's with brain mets--it would be part of the infusion with the regular chemo. Thank you all again, prayers to all.