Topic: Sacituzumab Govitecan (Trodelvy)

Forum: Triple-Negative Breast Cancer — Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: May 21, 2020 09:30AM

Posted on: May 21, 2020 09:30AM

Erich wrote:

Hello everyone. I was wondering if anyone(s) could share any experiences they have had using sacituzumab govitecan (Trodelvy) either in a clinical trial or as recently approved by the FDA.

We are trying to determine if it's the best plan of action for my wife at this time. There are 2 key things we are trying to determine.


1) How bad are the side effects (I've read everything from "terrible" to "manageable")?

2) Has it helped with your brain metastases or other CNS metastases? This is a tough question, I know. There is next to zero clinical data on it so far. Just trying to get any anecdotal evidence I can at this point.


Thank you all for any information on this! :)



Log in to post a reply

Page 7 of 22 (213 results)

Log in to post a reply

Jan 28, 2021 06:58AM DoubleBloom wrote:

It's nice to hear from you, Libby. Good to know that nothing is growing... now I pray for you that things start shrinking. Glad to know your side effects are in control. It must give you at least some relief.

Dx 5/11/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 6/1/2017 AC + T (Taxol) Surgery 11/27/2017 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 12/4/2017 Surgery 1/1/2018 Radiation Therapy 3/5/2018 Whole breast: Breast, Lymph nodes Surgery 8/31/2018 Reconstruction (right) Surgery 9/26/2018 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Dx 1/31/2019, IDC, 3cm, Stage IV, metastasized to brain, Grade 3, 0/7 nodes, ER-/PR-, HER2- Radiation Therapy 2/7/2019 External: Brain Surgery 3/21/2019 Reconstruction (left): Fat grafting; Reconstruction (right): Fat grafting Dx 10/16/2019, IDC, 3cm, Stage IV, metastasized to other, Grade 3, 0/7 nodes, ER-/PR-, HER2- Dx 8/28/2020, IDC, 3cm, Stage IV, metastasized to brain, Grade 3, 0/7 nodes, ER-/PR-, HER2-
Log in to post a reply

Jan 28, 2021 07:28AM anornurse wrote:

Libby, It's great to hear from you! Enjoy your next 3 months, you certainly derserve it! I grew up with a wonderful Mom and Dad who believed the glass was always half full. It must have rubbed off on me, lol! I have good news I would like to share and it's not about tnbc. Our daughter and son-in-law are going to have a baby in August! I'm going to be a Grandmom! Life is very special and it's nice to share with everyone! Sharon (anornurse)

Log in to post a reply

Jan 28, 2021 07:35AM DoubleBloom wrote:

HUGE CONGRATULATIONS Sharon!! That is something beyond special to look forward to. I'm very happy for you.

Dx 5/11/2017, IDC, Left, 3cm, Stage IIIA, Grade 3, 0/7 nodes, ER-/PR-, HER2- Chemotherapy 6/1/2017 AC + T (Taxol) Surgery 11/27/2017 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 12/4/2017 Surgery 1/1/2018 Radiation Therapy 3/5/2018 Whole breast: Breast, Lymph nodes Surgery 8/31/2018 Reconstruction (right) Surgery 9/26/2018 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Dx 1/31/2019, IDC, 3cm, Stage IV, metastasized to brain, Grade 3, 0/7 nodes, ER-/PR-, HER2- Radiation Therapy 2/7/2019 External: Brain Surgery 3/21/2019 Reconstruction (left): Fat grafting; Reconstruction (right): Fat grafting Dx 10/16/2019, IDC, 3cm, Stage IV, metastasized to other, Grade 3, 0/7 nodes, ER-/PR-, HER2- Dx 8/28/2020, IDC, 3cm, Stage IV, metastasized to brain, Grade 3, 0/7 nodes, ER-/PR-, HER2-
Log in to post a reply

Feb 13, 2021 11:28AM texaslaughter wrote:

Just popping in to say I started my 10th cycle yesterday. I continue to be blessed with a great response. Labs all normal, with tumor markers within the normal range indicating little to no cancer activity. Last scan on 12/30 shows significant changes and reductions, I have my next scan in a couple of weeks. This is the longest that any treatment has worked for me since I became metastatic. I've been back to work fulltime for over 3 months in a high paced role, working at home during COVID, and been able to manage it fine. Being at home allows me to take naps when I need them. :) Glad to see many more have been able to gain the benefits from this drug. It's not the easiest, especially in the beginning, but it works. It really does. All the best.

Log in to post a reply

Feb 13, 2021 08:26PM - edited Feb 13, 2021 08:27PM by norcals

Texaslaughter,

Thanks for checking in and sharing your good news. It's very helpful to know that Trodelvy is effective.

Anornurse, congrats to you and your family. Great news

Dx 6/17/2019, IDC, Left, 6cm+, Stage IIIC, Grade 3, ER-/PR-, HER2- Chemotherapy 6/23/2019 AC + T (Taxol) Chemotherapy 4/5/2020 Xeloda (capecitabine) Radiation Therapy Whole breast: Breast, Lymph nodes, Chest wall
Log in to post a reply

Feb 16, 2021 12:02PM sac321 wrote:

Is Trodelvy specific for Triple Negative or also can be used for er+/pr+/her-?

I don't have triple-negative; mine is strong ER+ with Her2-. Today, my MO decided to go with Trodelvy after she felt Xeloda is not working anymore. Your input is greatly appreciated

Dx 3/2018, ILC, Left, 6cm+, Stage IIIB, Grade 3, ER+/PR+, HER2- Dx 8/2020, Stage IV, metastasized to liver, ER+/PR-, HER2- Chemotherapy Halaven (eribulin) Chemotherapy Xeloda (capecitabine)
Log in to post a reply

Feb 16, 2021 12:12PM - edited Feb 16, 2021 12:14PM by moth

sac321, I've only seen it recommended for TNBC. My copy NCCN guidelines lists it for tnbc. Keytruda (another immunotherapy) recently got FDA approval for ER+ tumors with high tumor mutation burden &/or microsatellite instability (established by genomic tests such as Foundation One) but I've not seen trodelvy recommended for that. Maybe I missed something ... hope someone else wades in with evidence for this

ETA: link to FDA running updates on approved cancer treatments. Trodelvy is only listed for TNBC in April 2020. So I think this would be offlabel use?

https://www.fda.gov/drugs/resources-information-ap...


I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Radiation Therapy 3/3/2021 External Local Metastases 3/3/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy) Chemotherapy 6/1/2022 Other
Log in to post a reply

Feb 16, 2021 07:56PM sac321 wrote:

Thanks, moth. I noticed the same thing as you did, which is why I am asking here. I saw that "SusaninSF" had this treatment possibly because of her low Her2 (from the info below), but not sure.

Topic: Are you currently (or have you have been) in a Clinical Trial? (page 53)

Dx 3/2018, ILC, Left, 6cm+, Stage IIIB, Grade 3, ER+/PR+, HER2- Dx 8/2020, Stage IV, metastasized to liver, ER+/PR-, HER2- Chemotherapy Halaven (eribulin) Chemotherapy Xeloda (capecitabine)
Log in to post a reply

Mar 10, 2021 09:54AM Wanderingneedle wrote:

Unfortunately I may be moving off of Trodelvy. ☹️ My skin mets have returned - they are small bumps under my arm. I will have a scan in two weeks but in the meantime we’re returning my dosage to full strength for this cycle to see if it makes a difference since the skin mets almost completely disappeared after just the first cycle. After 3 cycles at full strength it was reduced because of side effects and that’s when the cancer stopped shrinking and stayed the same size. I just had a scan in January and showed nothing was growing or shrinking so I guess the cancer is pushing back now. My doctor ordered the blood test for circulating tumor cells dna and she has my last biopsy results and she clinical trials beginning soon and she researched TNBC. Almost all of her patients are metastatic. I’m in good hands. As much as I don’t like the side effects I’d like to get some more time out of this treatment before moving on because none of them seem to last long.

I hope everyone else is doing well! Spring is coming and so much to look forward to! 🌸🌼🌷🌱

Libby - Just trying to figure it all out and keep up with daily life. Dx 11/9/2017, IDC, Right, 6cm+, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2-, Targeted Therapy 1/22/2018 Ibrance (palbociclib) Hormonal Therapy 1/22/2018 Femara (letrozole) Chemotherapy 9/13/2018 Abraxane (albumin-bound or nab-paclitaxel) Hormonal Therapy 2/11/2019 Faslodex (fulvestrant) Chemotherapy 2/11/2019 Doxil (doxorubicin) Chemotherapy 2/26/2019 Halaven (eribulin) Dx 11/6/2019, IDC, Right, Stage IV, Grade 3, ER-/PR-, HER2-, Chemotherapy 12/3/2019 Abraxane (albumin-bound or nab-paclitaxel) Immunotherapy 12/4/2019 Tecentriq (atezolizumab) Chemotherapy 3/16/2020 Ixempra (ixabepilone) Chemotherapy 3/17/2020 Xeloda (capecitabine) Chemotherapy 5/11/2020 Xeloda (capecitabine) Targeted Therapy 8/31/2020 Trodelvy (sacituzumab govitecan-hziy) Radiation Therapy 4/19/2021 External: Bone Chemotherapy 8/19/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine)
Log in to post a reply

Mar 10, 2021 10:06AM moth wrote:

Wanderingneedle, oh I'm sorry to hear about the skin mets returning. Any chance they can be whackamoled through surgical excision or radiation? My team seems currently gung ho on treating anything that crops up as an oligoprogression (currently with rads) to delay moving off treatment. Do you have other mets which are responding at all?

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Radiation Therapy 3/3/2021 External Local Metastases 3/3/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy) Chemotherapy 6/1/2022 Other

Page 7 of 22 (213 results)

Scroll to top button