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Mar 26, 2021 12:31PM
Hi. I am adding a bit more detail to my question, in case anyone has thoughts :). I also posted on the liver mets and enhertu threads.
I am wondering if anyone has been on Trodelvy at a lower dose and then increased it with success? Also, does anyone have experience with both Trodelvy and Enhertu?
I was on Trodelvy June 2020-Jan 2021. I was on a 50% dose the entire time, and I had a really spectacular response, but unfortunately had progression in January. We debated going up in dose, but decided instead to try Abraxane. While I had one of the larger liver tumors respond to Abraxane, the rest have increased in size and activity, so I need to move on. I am again thinking about going back to Trodelvy, but at a higher dose. I am also looking into access to Enhertu. So, curious if anyone has any experience or words of wisdom.
I am heavily pre-treated and the Phase I trial world seems quiet right now....
Thanks for any thoughts :)
Jan '18: Diagnosed Stage IV w/ 2 liver mets. NED April-Oct. Stopped chemo. Jan '19: new liver mets + spread to bones. Restarted GemCarbo + Xgeva. Worked well for 6 months, then progressed. Currently on Eribulin, which is holding me stable
12/2016, IDC: Tubular/IBC, Left, Stage IIIC, Grade 2, ER+/PR+, HER2-
1/11/2017 AC + T (Taxol)
6/11/2017 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): DIEP flap
7/15/2017 Faslodex (fulvestrant)
7/18/2017 Whole breast: Breast, Lymph nodes, Chest wall
9/14/2017 Ibrance (palbociclib)
1/2018, Stage IV, metastasized to liver, Grade 3, ER-/PR-, HER2-
2/8/2018 Carboplatin (Paraplatin), Gemzar (gemcitabine)
1/2019, IDC: Tubular, Stage IV, metastasized to bone/liver
Carboplatin (Paraplatin), Gemzar (gemcitabine)