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Topic: Triple Negative Cancer- within 5 years from childbirth

Forum: Triple-Negative Breast Cancer —

Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: Feb 3, 2021 09:34PM

BanR wrote:

Hi everyone

Eager to know how many of you fall in my category- getting diagnosed with TNBC 5 years after childbirth. I breastfed my child for a good 2 years and gradually she weaned off.

What did your doctors say about pregnancy and lactation?

I come across articles on this topic even more these days- pregnancy raises the risk of TNBC the first 5 to 7 years but gives a protection in the long term.

Thank you

Theory of randomness...so unfair! Dx 9/12/2013, IDC, 1cm, Stage I, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/30/2013 Lumpectomy: Right Chemotherapy 11/5/2013 AC + T (Taxol) Radiation Therapy 3/10/2014
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Feb 3, 2021 10:06PM - edited Feb 3, 2021 10:07PM by NinjaMeow

I was diagnosed when my youngest was a year old.... I was 39 so I always wondered if advanced maternal age and childbirth were factors as well. I did not breast feed long term -

Diagnosed at 40 Dx 10/9/2013, DCIS, Right, 1cm, Stage IA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 11/19/2013 Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy 12/15/2013 AC + T (Taxol)
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Feb 3, 2021 10:59PM BanR wrote:

You are lucky that you did not get it in your first pregnancies.AT least you could complete your family. Not sure about advanced Maternal age- did you discuss with your doctor?

Theory of randomness...so unfair! Dx 9/12/2013, IDC, 1cm, Stage I, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/30/2013 Lumpectomy: Right Chemotherapy 11/5/2013 AC + T (Taxol) Radiation Therapy 3/10/2014
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Feb 4, 2021 10:08PM NinjaMeow wrote:

It is funny bc the irony is I specifically remember reading about how AMA and potential of increased risk of breast cancer and a few months before diagnosis I read an article about TNBC bc I had never heard of it before 🙈 Mydoctors never really brought things like this up before or after diagnosis. I have found so many varying answers from exposure to a chemical at a young age or other theories..... I finally concluded that I don’t think there is a silver bullet answer.

Diagnosed at 40 Dx 10/9/2013, DCIS, Right, 1cm, Stage IA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 11/19/2013 Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy 12/15/2013 AC + T (Taxol)
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Feb 4, 2021 10:26PM exbrnxgrl wrote:

ninjameow,

There are an abundance of theories, suspicions and tangential connections that may or may not explain what causes bc. Certain things, like genetic mutations, do pre-dispose someone to greater likelihood of developing bc. Other things, diet, environment etc. are harder to pin down. In general we should all aim for healthy lifestyles (but compulsive diets/protocols are still mainly theoretical).

Anecdotes about those who are in similar circumstances to you can be comforting but they are not data. Remember this forum is largely composed of those who have bc but you have no way of comparing them to those who were pregnant in that 5-7 year window and did not develop bc. Research can sometimes be confusing and contradictory but anecdotes are just personal stories with lots of confounding factors that may play into how someone developed or didn’t develop bc. It is unfortunate but in many, many cases we may never know (at this point in time) why someone developed bc. All the best

Bilateral mx 9/7/11 with one step ns reconstruction. As of 11/21/11, 2cm met to upper left femur Dx 7/8/2011, IDC, Left, 4cm, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Surgery 9/7/2011 Lymph node removal: Left; Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Dx 11/2011, IDC, Left, 4cm, Stage IV, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 11/21/2011 Arimidex (anastrozole) Radiation Therapy 11/21/2011 Bone Hormonal Therapy 6/19/2014 Femara (letrozole) Hormonal Therapy Aromasin (exemestane)
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Feb 4, 2021 11:00PM NinjaMeow wrote:

Exactly!

Diagnosed at 40 Dx 10/9/2013, DCIS, Right, 1cm, Stage IA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Surgery 11/19/2013 Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy 12/15/2013 AC + T (Taxol)
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Feb 10, 2021 02:11AM BanR wrote:

The latest research - 2019 and there is more in 2020 publication.

There could be an entire list that can be triggers.

Pregnancy is one of them- it wont affect the majority but will affect a few.

Some more interesting reads on medical journals on the process of cell differentiation in a lactating breast and readjustment after weaning off .


https://cancerres.aacrjournals.org/content/80/9/17...


Theory of randomness...so unfair! Dx 9/12/2013, IDC, 1cm, Stage I, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/30/2013 Lumpectomy: Right Chemotherapy 11/5/2013 AC + T (Taxol) Radiation Therapy 3/10/2014
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Feb 10, 2021 03:19AM moth wrote:

Not being pregnant is also a risk factor for breast cancer.

Not lactating is also a risk factor for breast cancer. (& in fact, the response is dose related - the more months a woman breastfeeds, the lower her risk of breast cancer).

women's bodies are complicated in no small part because of two X chromosomes usually one of them is actually silenced but variations in expression may be the reason why women are more prone to auto immune disorders https://www.nature.com/articles/nri2815

we also have to be able to carry a parasite (ie the fetus) which requires our immune system to change how it views 'self' versus 'non self'. During pregnancy and lactation, numerous tissues expand in number - which again is a risky proposition as it requires stopping the normal cellular "stop reproducing" signals. Turning those off and not turning them back on again leads to uncontrolled cellular growth which is essentially cancer.

I think at the cellular level we will continue to discover all sorts of mechanisms for why cancer is triggered in various scenarios.

I'm a triple neg but I was diagnosed when my youngest was 19. I did breastfeed for many years so perhaps that delayed things - it's impossible really to drill down the reasons for an individual's disease, just for the population trendlines.

My doctors have always been very strong advocates of lactation and have mentioned that pregnancy is protective.

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/16/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone
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Feb 11, 2021 12:55AM - edited Feb 11, 2021 12:56AM by BanR

Yes Pregnancy is protective, however the protection starts 20 years later after the last pregnancy is what the current research points to. In Medical science Its called the PPBC ( Post Partum Breast Cancer). This is something that is getting published in medical journals 2019 onwards and before that I had come across just a local study dated 2012 which indicated the same.

The idea of this research is not to scare women but to increase awareness that after pregnancy the risk of TNBC is higher for the next 5 years or so. Hence women and doctors need to be more cognizant. Esp when you are breast feeding it is very easy to take a new lump or a recurring mastitis infection casually.

Breast density, a recent pregnancy, genetic mutations, Lifestyle issues, exposure to pollutants, age of the woman, age of puberty onset etc - the list is long. In fact in many countries the law mandates that a women should be told of high breast density so that her follow ups are designed accordingly and that high breast density is as much a risk factor for cancer as a positive genetic mutation.

Of the entire list that can cause TNBC, we don't know who among us fell in what category. There are 7 subsets of TNBC and we are dealing with a disease that is till date defined by the absence of something and not by the presence of anything.

Theory of randomness...so unfair! Dx 9/12/2013, IDC, 1cm, Stage I, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/30/2013 Lumpectomy: Right Chemotherapy 11/5/2013 AC + T (Taxol) Radiation Therapy 3/10/2014
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Feb 11, 2021 01:38AM exbrnxgrl wrote:

BanR,

I love your tag line, “Theory of randomness...so unfair.” I have learned to embrace randomness to a certain extent 😊

Bilateral mx 9/7/11 with one step ns reconstruction. As of 11/21/11, 2cm met to upper left femur Dx 7/8/2011, IDC, Left, 4cm, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Surgery 9/7/2011 Lymph node removal: Left; Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Dx 11/2011, IDC, Left, 4cm, Stage IV, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 11/21/2011 Arimidex (anastrozole) Radiation Therapy 11/21/2011 Bone Hormonal Therapy 6/19/2014 Femara (letrozole) Hormonal Therapy Aromasin (exemestane)
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Feb 18, 2021 09:59PM BanR wrote:

exbrnxgrl.... :) Thanks

Theory of randomness...so unfair! Dx 9/12/2013, IDC, 1cm, Stage I, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 9/30/2013 Lumpectomy: Right Chemotherapy 11/5/2013 AC + T (Taxol) Radiation Therapy 3/10/2014
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Apr 9, 2021 06:44AM santabarbarian wrote:

moth what you wrote about the breast and the changes to a woman's body... you put that really well!

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/13/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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Apr 19, 2021 01:18AM AnnaMO wrote:

I was diagnosed when my youngest was in Kindergarten. She was 5. I hadn't breastfed since my oldest who was 10 at the time of dx.

Anna Dx 12/4/2015, IDC, Right, 2cm, Stage IIIA, Grade 3, 6/17 nodes, ER-/PR-, HER2- Chemotherapy 12/29/2015 AC + T (Taxol) Surgery 5/12/2016 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Prophylactic ovary removal Radiation Therapy 10/10/2016 Lymph nodes, Chest wall Chemotherapy Carboplatin (Paraplatin) Chemotherapy Xeloda (capecitabine)

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