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Topic: Some Triple-Negative BCs Are More Aggressive Than Others

Forum: Triple-Negative Breast Cancer —

Share with others who have ER-/PR-/HER2- breast cancer.

Posted on: Apr 27, 2021 05:11PM

Moderators wrote:

Some Triple-Negative Breast Cancers Are More Aggressive Than Others
April 22, 2021

Not all triple-negative breast cancers are the same, with certain subtypes being more aggressive than others, according to a study. Read more...

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Apr 29, 2021 08:32PM santabarbarian wrote:

Even *within* plain old ductal carcinoma, there are distinct subtypes.

These subtypes drive chemo responsiveness. There are clusters of many genes that roughly delineate the subtypes in a scattergram. Basal like (BL1, BL2), mesenchyma (M), mesenchymal stem like (MSL), Immuno-modulatory (IM), and Luminal Androgen receptor (LAR).

https://www.nature.com/articles/s41598-019-55710-w


pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/13/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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Apr 30, 2021 02:47PM NorCalS wrote:

Thank you Moderators for posting this article.

Dx 6/17/2019, IDC, Left, 6cm+, Stage IIIC, Grade 3, ER-/PR-, HER2- Chemotherapy 6/23/2019 AC + T (Taxol) Chemotherapy 4/5/2020 Xeloda (capecitabine) Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall
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Apr 30, 2021 02:50PM Moderators wrote:

You're welcome NorCalS!

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Jun 28, 2021 05:07PM Easymac08 wrote:

how do you find out what your subtype is?

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Jun 29, 2021 08:10AM santabarbarian wrote:

You can ask your MO... It's not always clear. The high grade ones are often Basal l or basal like. The article I posted above explains some of the features of the subtypes.

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/13/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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Jul 13, 2021 09:47AM Easymac08 wrote:

do you know yours? I asked my onco. She said she thinks mine is basil like because "most tbnc are". 😑

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