Jul 30, 2021 03:18PM mightlybird01 wrote:

Hi Ntlw12,

We don't know much about your diagnosis apart from the fact it is triple negative. Do you have any more information, such as tumor size, potential lymph node involvement, genetic testing, what type (IDC or ILC)?

But this does sound like an unusual regime for the standard TNBC, but times are changing and it looks indeed very interesting and powerful. And as long as you trust this Dr. and your hospital, it sounds as this could be a good combo of all drugs known to work well with TNBC. But for a first line of treatment for early stage TNBC it is unusual. I am curious to see what other people think. Are you treated in a major cancer center?

Good luck and keep the faith!

Jul 30, 2021 03:50PM Ntlw12 wrote:

I have a 4.5 cm mass. IDC, nothing else showed up in Breast MRI. I have CT and bone scan on Monday. I did have genetic testing, but results aren’t in yet. I’m 38 and my mother had colorectal cancer (diagnosed at 45, stage IV and at 58 she is still here with no cancer!) and my grandmother had ovarian cancer.

maybe I’m reading all these papers wrong. I am going to a great place that is a branch of Roswell Park out of Buffalo so I have faith in their plan.

Jul 30, 2021 07:35PM moth wrote:

Ntlw12, I think they're proposing state of the art, most recent evidence based protocol.

Here is the July 27 Merck release about Keytruda getting the FDA approval. You'll see the first para essentially describes your treament regimen.

https://www.merck.com/news/fda-approves-keytruda-p...

I'll be SO interested to hear how you do! for ages early TNs usually got AC+T so that's what you'll see here in siglines. You're a groundbreaker but you're following in the footsteps of really good clinical trial results so it's really excellent that you can access this treatment right out of the gate!

best wishes & do let us all know how it's going.

ps. I think TN will need a thread for pembro for early stage (we have a thread for in the mets section already but this is a whole different thing)

Jul 31, 2021 01:42AM norcals wrote:

Ntlw12,

It looks like you are getting the newest “standard of care” treatment for TNBC. It’s pretty exciting and I hope the best for you. Keep us posted on how you’re doing. Like Moth said, old protocol was AC (adriamycin, cytoxan) for four cycles - once every two weeks, then taxol for every week for 12 weeks. I think Santabarbarian had a slightly different protocol for her TNBC (carboplatin instead of adriamycin?).

Hopefully, those who were in the clinical trials for keytruda can chime in. You can also check this site for the keytruda thread.