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Topic: Discovery of Antibody destroys breast cancer

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Jul 9, 2007 03:49AM

cp418 wrote:

This news looks awesome considering the recent news in the USA that NIH is cutting funds for cancer research. Thank God other countries are still forging ahead. In regards to 20 million for development - - - that is PEANUTS for the the big pharmaceutical giants considering some CEOs get 300 million at year end bonus. Joann

Researcher�s discovery may revolutionise breast cancer treatment
Sun, 08 Jul 2007 06:15p.m.

An Auckland breast cancer researcher has made a breakthrough that could revolutionise breast cancer treatment.

Peter Lobie's work is still in its early stages, but he has found an anti-body that kills human cancer cells implanted in mice.

After a decade of research he has discovered a new antibody that breaks down breast cancer cells and it is aggressive.

�We were pretty surprised because we didn't expect these molecules to be so powerful we thought maybe they'd have some effects on the cancer process but the deeper we dug into these molecules the more we found they were really central to the cancer process,�� Lobie told 3 News.

The antibody, known as 1C6, has only been tested on mice but the results have been dramatic.

Human breast cancer tumours completely disappeared from mice after only 2 weeks of treatment.

The antibody is injected into the blood, it finds breast cancer cells, and then attacks 2 of the proteins the cell produces to stimulate growth.

The antibody covers the proteins and stops them from working then the cancer cell dies.

1C6 is similar to Herceptin but where Herceptin works for 20 percent of breast cancers, this antibody has the potential to attack 80 percent

The company funding the research says it is the most exciting development in breast cancer research in 25 years.

Human trials are still at least 18 months away, and the drug will cost around US $20 million to develop.

The Breast Cancer Research trust says even though there are no guarantees, it's worth the investment.

Some breast cancer specialists 3 News has spoken to are more cautious, they say exciting research like this has fizzled out in the past, but they agree if 1C6 is successful it will revolutionise breast cancer treatment.

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Jul 9, 2007 04:18AM rue2u wrote:


Very exciting! Let's hope we see more about this soon. I hope they can get the human trials underway more quickly than the 18 mos. that was mentioned. Thanks!

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Jul 15, 2007 02:19PM WendyK wrote:

Praying that this one is it!

Hoping for the future and living for today! Dx 12/13/2004, IDC, 1cm, Stage I, Grade 3, 0/8 nodes, ER+/PR+, HER2-

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