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Topic: Anti-inflammatory Drug May Fight Breast Cancer

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: May 6, 2011 07:37AM

cp418 wrote:

http://www.medicalnewstoday.com/articles/224395.php

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May 6, 2011 09:37AM Valgirl wrote:

Interesting...

Lumpectomy , 30 Rads, No Chemo , Arimidex for 5 years Dx 9/17/2010, IDC, <1cm, Stage I, Grade 1, 0/3 nodes, ER+/PR+, HER2-
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May 6, 2011 09:58AM voraciousreader wrote:

Yep. Been reading about this for years. When they refer to pre-clinical studies, I recall meta analysis suggesting fewer people got cancers while taking anti- inflammatories. There has been on going debate about the use of anti- inflammatories in the reduction in heart attacks as well. Some folks that statins have anti- inflammatory properties and that's what is actually reducing heart attacks and not the cholesterol reduction per se. Thanks for posting.

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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May 6, 2011 11:43AM otter wrote:

I wish this worked with something as innocuous as Advil.  Not sure I want to take a COX-2 inhibitor long-term, because of all the secondary problems they cause.  Then again, I'm already taking Arimidex and a statin long-term...  <sigh>

otter

Dx 2008, IDC, Stage IA, Grade 2, 0/3 nodes, ER+/PR-, HER2-
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May 6, 2011 11:54AM cp418 wrote:

When I read COX-2 inhibitor I can't help thinking about all the serious problems from Vioxx.

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May 6, 2011 12:02PM Luan wrote:

Hello, just thought I would add a word of caution.  Sounds too much like Celebrex for comfort and which has had a very bad wrap. I suspect the pharmacos are trying to sugar coat it for some other use.  I worked with someone who took this drug and it made her extremely sick.  I'm taking two baby aspirins a day which is much safer, I feel and I defnitely will try the miracle of Boswellia which some ladies on this site recommended.

"People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as celecoxib may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death"

www.nlm.nih.gov/medlineplus/druginfo/meds/a699022.html

Celebrex and Vioxx are two drugs that have previously been administered for arthritis conditions. In fact, the two - known as Cox-2 inhibitors - were touted as miracle drugs for those suffering from an arthritic disease.

However, researchers have linked them to an increase in blood clots, heart attacks, and stroke risk - in humans. The Cleveland Clinic conducted the study, which appeared in the Journal of the American Medical Association. Celebrex is still widely used - to the tune of more than $6 billion this year, despite the rather alarming risks associated with using these types of drugs"

Don't knock at death's door. Ring the bell and run. He hates that. Dx 10/2009, IDC, 2cm, Stage IIIA, Grade 1, 2/5 nodes, ER+/PR+, HER2-
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May 6, 2011 12:06PM - edited May 6, 2011 12:07PM by otter

I have read, and been told by one of my docs (my PCP? my med onco?), that celecoxib (a.k.a. Celebrex) looks lke it is the "least harmful" of the COX-2 inhibitors.... so far, anyway.

otter

Dx 2008, IDC, Stage IA, Grade 2, 0/3 nodes, ER+/PR-, HER2-
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May 6, 2011 12:21PM Beeb75 wrote:

I'm very intrigued by the connection between inflammation and cancer. I, for one, always had extremely painful breasts before my period. They felt bruised, swollen or inflamed. This happened every single month...and just seems too coincidental to not be related to the BC I developed by age 35. 

Also, I sometimes wonder if the connection between smoking and lung cancer relates to inflammation in the lung.

And doesn't it seem odd/ironic that so many people develop cancer in areas that they use/overuse in their daily lives (like opera singers who develop throat cancers, or cyclists who develop testicular cancers, or runners who develop leg muscle cancers [just read about that last one!])

Anyway, I think there has been some research done along these lines, though I don't know much about it.

Seems logical that if a tissue is harmed or challenged a lot, there will be a lot of immune system activity involved in its repair. If the immune system signals cells to proliferate, to repair problems, then something might go wrong in that process whereby cells get mistakes that keep them growing. 

I hope we'll see more related to all this...in the meantime, I'm taking baby aspirin too (onc approved.)

Dx 7/2010, IDC, 2cm, Stage IIB, Grade 3, 1/20 nodes, ER+/PR+, HER2-
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May 6, 2011 03:26PM voraciousreader wrote:

Anyone want to read a terrific book? I mean on the level of Silent Spring. Check out Dr John Abramson's book Overdosed America. Absolutely on of the most important books that I ever reas. The book was published two weeks before the Vioxx debacle. I want to digress and say that while the Celebrex was used in the study, I think the more important thing is that it was the anti inflammatory properties of the med that were being tested. Perhaps one day there will be a pill that contains all the anti inflammatory benefits without the nasty side effects.....

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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May 6, 2011 03:37PM duckyb1 wrote:

True about cox-2 inhibitors............especially in regard to heart attack........some are never affected by the drug, others are very affected...........so this needs a lot more studies........worked for a Pharma Co.............they love to push their drugs for things other then it was manufactured for.......called......off label use.............

Ducky Dx 2/15/2011, IDC, Right, 1cm, Grade 1, 0/8 nodes, ER+/PR+, HER2- Radiation Therapy 4/24/2011 Whole-breast: Breast
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May 6, 2011 03:38PM BarbaraA wrote:

I agree with VR. Great book! I have it on my iPad and Kindle so I can reread it from time to time.

Sometimes you're the bug and sometimes you're the windshield. Dx 4/30/2010, IDC, 1cm, Stage IB, Grade 2, 1/4 nodes, ER+/PR-, HER2- Hormonal Therapy 11/24/2014 Femara (letrozole) Dx 11/25/2014, IDC, Stage IV, metastasized to bone, ER+
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May 6, 2011 03:42PM Bold wrote:

My Breast Surgeon Kristi Funk! Has told me and the world on the show The Doctors that Taking Advil is very good for preventing BC. She also recommends 3 glasses of green tea a day.

started TCH x 6 Dec 29, 2008 Dx 11/6/2008, IDC, 3cm, Stage IIA, Grade 3, 0/3 nodes, ER-/PR-, HER2+
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Mar 15, 2012 12:02AM - edited Apr 30, 2019 11:43PM by AMP47

This Post was deleted by AMP47.
Dx 1/16/2009, IDC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- (IHC) Surgery 2/14/2009 Lumpectomy: Left; Lymph node removal: Left, Sentinel
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Jun 15, 2019 08:32PM - edited Jun 15, 2019 08:33PM by AMP47

Not sure who delete my post- it was not me?

Dx 1/16/2009, IDC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- (IHC) Surgery 2/14/2009 Lumpectomy: Left; Lymph node removal: Left, Sentinel

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