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Topic: low dose aspirin may act like an aromatase inhibitor

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: May 1, 2017 10:45AM

wallycat wrote:

http://www.cnn.com/2017/05/01/health/breast-cancer...


Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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May 1, 2017 10:52PM Meow13 wrote:

Could it be an aspirin instead of anastrozole could be just as effective? I feel like doctors would not accept this you know a treatment that doesn't have horrible side effEcts couldn't possibly be effective.

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May 1, 2017 11:28PM Artista928 wrote:

Awesome if true. I take low dose and have for months since I'm on Tamoxifen. MO recommended it to help prevent blood clots since I kept my port.

Dx'd at 50. Doing it all, all by myself. Stopped Letrozole after 5 weeks. Debilitating se's. Back on Tamox now. Dx 6/2/2015, IDC, Left, 6cm+, Stage IIIA, Grade 3, 1/4 nodes, ER+/PR+, HER2- (DUAL) Surgery 8/6/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 11/3/2015 AC + T (Taxotere) Radiation Therapy 5/2/2016 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 6/28/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 12/9/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 2/14/2017 Femara (letrozole) Hormonal Therapy 3/26/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 9/1/2017 Reconstruction (right): Fat grafting, Silicone implant
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May 2, 2017 05:11AM dtad wrote:

Meow...I agree! Something that simple will never happen! Imagine all the money pharmaceutical companies would lose? Just like how you never hear that weight loss and exercise can lower recurrence rates up to 40 percent. Sad but true.

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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May 2, 2017 06:05AM keepthefaith wrote:

I have been taking a baby aspirin for a couple of years....I had to ask my MO...she didn't bring it up. I, too, was fearful of clots and stroke, being in Tamoxifen. Too bad it isn't protocol for all MO's to recommend.

Dx 9/17/2013, IDC, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 10/18/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 12/3/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 12/26/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 1/16/2014 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 2/11/2014 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 4/1/2014 Breast Hormonal Therapy 5/23/2014
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May 2, 2017 07:18AM claireinaz wrote:

I'm concerned that this article doesn't state that aspirin prevents recurrence--just lowers breast cancer risk. Thoughts? I really need to hear the "recurrence" word in research, I guess.

9/29/11 ILC, 2 c. stage II grade 1, ER/PR+ HER2-, 6/11 nodes, lumpectomy, DDAC x 4, Taxol x 12, 33 rads, Tamoxifen/arimidex/aromasin, BMX/immed recon 7/3/13 "In the midst of winter, I found in me an invincible summer.” Albert Camus
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May 2, 2017 07:20AM ksusan wrote:

I took daily baby aspirin for years before my dx. I also took Metformin.

Mutant uprising quashed. Dx 1/2015, IDC, Right, Stage IIA, 1/1 nodes, ER+/PR+, HER2- Dx 1/2015, DCIS, Left, Stage 0, Grade 3, 0/2 nodes Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal: Sentinel; Mastectomy: Left, Right Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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May 2, 2017 08:12AM - edited May 2, 2017 08:22AM by wallycat

I started taking a full dose daily when I was on tamoxifen and arimidex; I've (maybe last 1-1/2 years) switched to baby aspirin...and I only take one. Not sure if the study said low dose = 2 baby aspirin or not.

I think it is all a crap shoot because I honestly think epigenetics and genetics play a huge role (and the study that said genetics did not play a big role, I personally think they over generalized).

It is odd that a standard dose did not protect while a baby aspirin did...you would think the same mechanism was in play.

The fact that they mentioned it acted like an aromatase inhibitor to me, implies trying to limit recurrence--because most women won't take that until after diagnosis. But that's just my brain trying to justify that I'm "doing something" and not flying without a net!


Here is another version of that story: http://www.medicalnewstoday.com/articles/317248.ph...

It is an 81mg aspirin and specific for er+/her- (which was mentioned in the other study).

Interesting that they say "other NSAIDS" not effective yet last year, there was a study out that said ibuprofen was better than aspirin for breast cancer. **shaking head*** the saga continues....


Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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May 2, 2017 02:53PM Brutersmom wrote:

I have had so many issues with quality of life on the aromatase inhibitors. I have had to stop. Nothing is a guarantee that our cancer won't come back. I am sure the big drug companies don't want this information shared and if it is to be tested further it will have to be done in the private arena. I am thinking that this might be one way for someone like myself who can't function on the aromatase inhibitors to at least feel like they are doing a little something to keep cancer at bay.

Diagnosed at 62, No lump, found on a routine mammogram Dx 7/29/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (DUAL) Surgery 8/7/2015 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 8/19/2015 Lumpectomy: Right Radiation Therapy 9/28/2015 Whole-breast: Breast Hormonal Therapy 10/24/2015 Arimidex (anastrozole)
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May 2, 2017 02:57PM Artista928 wrote:

I would ask your pcp first if there's any medical reason why you can't do low dose ASA. I feel better I'm on it since I should be on an AI but can't handle it so I'm back on Tamox.

Dx'd at 50. Doing it all, all by myself. Stopped Letrozole after 5 weeks. Debilitating se's. Back on Tamox now. Dx 6/2/2015, IDC, Left, 6cm+, Stage IIIA, Grade 3, 1/4 nodes, ER+/PR+, HER2- (DUAL) Surgery 8/6/2015 Lymph node removal: Left, Sentinel; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 11/3/2015 AC + T (Taxotere) Radiation Therapy 5/2/2016 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 6/28/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 12/9/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 2/14/2017 Femara (letrozole) Hormonal Therapy 3/26/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 9/1/2017 Reconstruction (right): Fat grafting, Silicone implant
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May 2, 2017 05:23PM ruthbru wrote:

I have taken a low dose aspirin for years (heart disease runs rampant in my family). My heart is great, and although it didn't prevent me from getting cancer, if it can lower the chance of recurrence, that will be a great bonus. (Like anything, check with your doctor before you start.)

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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May 2, 2017 05:27PM ChiSandy wrote:

Been taking low-dose aspirin daily for the last 5 years, and I still got ER+ bc. Don’t pin all your hopes on this.

Diagnosed at 64 on routine annual mammo, no lump. OncotypeDX 16. I cried because I had no shoes...but then again, I won’t get blisters.... Dx 9/9/2015, IDC, Right, 1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2- (IHC) Surgery 9/23/2015 Lumpectomy: Right Radiation Therapy 11/2/2015 3DCRT: Breast Hormonal Therapy 12/31/2015 Femara (letrozole)
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May 9, 2017 11:36AM Moderators wrote:

Hi all,

Thought you might be interested in the main Breastcancer.org site's take on this:

Study Suggests Link Between Low-Dose Aspirin and Lower Risk for Specific Type of Breast Cancer
May 4, 2017

A preliminary study suggests that women who take low-dose aspirin 3 or more times per week have a lower risk of hormone-receptor-positive, HER2-negative breast cancer. Still, it's too soon to recommend women start taking low-dose aspirin to reduce breast cancer risk. Read more...

To send a Private Message to the Mods: community.breastcancer.org/mem...
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Dec 4, 2019 07:49PM - edited Dec 12, 2019 09:20PM by KIDI919

This Post was deleted by KIDI919.
Dx 9/17/2019, DCIS/IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (IHC) Radiation Therapy 1/15/2020 Whole-breast: Breast

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