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All TopicsForum: Clinical Trials, Research News, Podcasts, Study Results → Topic: Breaking Research News from sources other than breastcancer.org

Topic: Breaking Research News from sources other than breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 21, 2017 12:31AM - edited Nov 21, 2017 12:35AM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Nov 21, 2017 12:34AM Lumpie wrote:

Intratumoral Injection of c-Met CAR T Cells in Metastatic Breast Cancer

http://www.practiceupdate.com/c/60815/67/13/?elsca...

In patients with metastatic breast cancer, intratumoral injections of mRNA c-Met-CAR T cells evoked a tumor-specific inflammatory response and were well-tolerated.

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Nov 21, 2017 12:45AM Lumpie wrote:

GoldenGirls posted this link elsewhere. So fascinating, I have to re-post:

Article online (Baltimore Sun): http://www.baltimoresun.com/health/bs-hs-cancer-trigger-20170625-story.html

Johns Hopkins researchers say they've unlocked key to cancer metastasis and how to slow it

Many researchers believe metastasis happens after the primary tumor reaches a certain size, but Jayatilaka found it was the tumor's density that determined when it would metastasize. The study was published online May 26 (2017) in the journal Nature Communications.

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Nov 23, 2017 07:43AM - edited Nov 23, 2017 07:45AM by Lumpie

Over-the-counter decongestant found to be effective inhibitor of tumor stroma

https://www.news-medical.net/news/20171120/Over-th...

Epigenetic editing in healthy breast cells can set off chain reaction for tumor initiation

https://www.news-medical.net/news/20171113/Epigene...

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Nov 30, 2017 10:04PM Lumpie wrote:

Wonder if anyone else is reading these? Here's another that I found interesting to me:

'Chemo brain' may start as tumors form and develop, suggests study

https://www.news-medical.net/news/20171121/e28098C...

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 7, 2017 12:51AM Lumpie wrote:

Replacing lymph nodes to ease painful legacy of cancer care

https://apnews.com/2044b48832ec48179dfd33d790785e9...

"...replacing under-arm lymph nodes lost in cancer surgery — ... a small but growing number of hospitals offer microsurgical attempts at relief from lymphedema..."

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 7, 2017 02:34PM Hopeful82014 wrote:

Hi, Lumpie. Yes - I'm following this thread with interest. I try to stay up on things and yet you're coming up with studies that rarely overlap with what I've already found, so thank you for a valuable contribution.


Dx 2014, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR-, HER2-
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Dec 13, 2017 06:32PM Lumpie wrote:

Cancer breakthrough: Nanoparticles used to detect micro tumors

https://www.medicalnewstoday.com/articles/320338.p...

(Now if they will just do something about those micro tumors!)

Hopeful: so glad to know that you are following! This list is not at all systematic... just interesting stuff I run across. I hope it will be of interest to others, too... and maybe inspire hope!

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 13, 2017 06:38PM Lumpie wrote:

New research that looks at the long-term effects of chemotherapy on breast cancer survivors finds it weakens parts of the immune system for at least 9 months after treatment.

https://www.medicalnewstoday.com/articles/305566.p...


"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 13, 2017 06:56PM Lumpie wrote:

Vitamin C can target and kill cancer stem cells, study shows

https://www.medicalnewstoday.com/articles/316334.p...


"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 14, 2017 08:51AM claireinaz wrote:

RE: cancer and Vit C. Would like to know how they conducted the research? Was a supplement taken by mouth, or was it all in-lab using petrie dishes, etc. instead?


9/29/11 ILC, 2 c. stage II grade 1, ER/PR+ HER2-, 6/11 nodes, lumpectomy, DDAC x 4, Taxol x 12, 33 rads, Tamoxifen/arimidex/aromasin, BMX/immed recon 7/3/13 "In the midst of winter, I found in me an invincible summer.” Albert Camus
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Dec 14, 2017 11:53AM MTwoman wrote:

Lumpie, here is a related article: http://ucsdnews.ucsd.edu/pressrelease/drug_suppresses_spread_of_breast_cancer_caused_by_stem_like_cells

Clair, these are NOT human studies being conducted. These are cell line studies, i.e. petri dishes. They are trying to model pathways and see if their hypothesis holds up. Very early stages.

An important distinction to make is that these "stem-like cells" are rare, and don't appear in most bc. This won't be an avenue of treatment for some time as it is in the patient-derived cell line and mouse model research stage. Very interesting, but shouldn't impact anyone's care in the very near future.

Dx 12/10/2002, DCIS, Right, 1cm, Stage 0, Grade 2, 0/3 nodes, ER-/PR-, HER2- Surgery 12/19/2002 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 12/23/2003 Reconstruction (right): Nipple reconstruction Surgery Reconstruction (right): Saline implant Surgery Reconstruction (right): Tissue expander placement Surgery Mastectomy: Right
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Dec 14, 2017 02:23PM Hopeful82014 wrote:

This study of CTCs is intriguing:

http://www.cancernetwork.com/sabcs/ctcs-can-predict-hr-positive-breast-cancer-recurrence/?GUID=D53A0013-69D7-4B59-83CC-F2AF978428FB&XGUID=&rememberme=1&ts=14122017



Dx 2014, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR-, HER2-
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Dec 14, 2017 04:18PM MTwoman wrote:

I find this proof of concept study interesting as well. Hopefully, they'll sufficiently power a study with long enough follow up time to make this generalizable. I keep seeing lots of small studies with short follow up duration. They are intriguing, but not sure if they are all being followed by larger ones.

Dx 12/10/2002, DCIS, Right, 1cm, Stage 0, Grade 2, 0/3 nodes, ER-/PR-, HER2- Surgery 12/19/2002 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 12/23/2003 Reconstruction (right): Nipple reconstruction Surgery Reconstruction (right): Saline implant Surgery Reconstruction (right): Tissue expander placement Surgery Mastectomy: Right
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Dec 14, 2017 04:51PM Hopeful82014 wrote:

I agree, MTwoman. It seems at times as though there's a lot of 'churn,' a lot that's kind of sort of in the pipeline but rarely coming into play as far as treatment, risk prediction/reduction, etc. :(

Dx 2014, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR-, HER2-
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Dec 14, 2017 06:58PM Lumpie wrote:

Here's a link to the Vitamin C study abstract. A PDF is available without charge.

http://www.oncotarget.com/index.php?journal=oncota...

Yes, looks like petri dish stage. I agree, it can be discouraging that it can be a LONG pipeline to a useful treatment for us humans! With so much seemingly promising research, it sometimes feels like little comes out the other end of that pipe!

"Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Dec 15, 2017 10:52AM MTwoman wrote:

Thanks Lumpie, really smart people doing exciting research. I do hope that it moves into the stage with actual people at some point!

Dx 12/10/2002, DCIS, Right, 1cm, Stage 0, Grade 2, 0/3 nodes, ER-/PR-, HER2- Surgery 12/19/2002 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 12/23/2003 Reconstruction (right): Nipple reconstruction Surgery Reconstruction (right): Saline implant Surgery Reconstruction (right): Tissue expander placement Surgery Mastectomy: Right
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Dec 15, 2017 06:19PM gigibee wrote:

https://www.washingtonpost.com/national/health-sci...


Dx 8/31/2017, DCIS/IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 10/30/2017 Lumpectomy: Right; Lymph node removal: Underarm/Axillary
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9 hours ago MTwoman wrote:

that IS more promising. The largest study so far has only had 547 women, so it does need some more work. "Results suggest they someday may help reveal" is a nice way of impressing it's potential. So glad that so much research continues to show promise

Dx 12/10/2002, DCIS, Right, 1cm, Stage 0, Grade 2, 0/3 nodes, ER-/PR-, HER2- Surgery 12/19/2002 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 12/23/2003 Reconstruction (right): Nipple reconstruction Surgery Reconstruction (right): Saline implant Surgery Reconstruction (right): Tissue expander placement Surgery Mastectomy: Right

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