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Topic: Breaking Research News from sources other than breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 21, 2017 12:31AM - edited Nov 21, 2017 12:35AM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Posts 391 - 420 (924 total)

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Jul 8, 2018 03:38PM - edited Jul 8, 2018 11:06PM by Chemokaze

Top oncologist to study effect of diet on cancer drugs:

http://flip.it/1Dcoeh

10/2018: NEAD; 7/2018: Onward to Verzenio, Zometa, Faslodex, & CyberKnife to single met to L4 spine. Dx 9/1996, IDC, Left, Stage IB, Grade 3, 0/21 nodes, ER+/PR+ Dx 5/2016, IDC, Right, Stage IIIC, Grade 2, 14/21 nodes, ER+/PR+, HER2- Dx 6/2018, Stage IV, metastasized to bone
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Jul 9, 2018 03:39PM aterry wrote:

Lumpie, The Medscape article about Starbucks coffee is so interesting. I just recently became aware of the California warning (late to the game, I guess) and now I'm seeing it all over the place. I just returned a lawn sprinkler to Ace hardware (to corporate, not the store) because it has the warning. I'm guessing there are many, many items with the warning. Now that I know to look I'll probably see it everywhere.

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/22/2017 Chemotherapy AC + T (Taxol)
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Jul 9, 2018 04:25PM marijen wrote:

aterry, wait! What? A lawn sprinkler may cause cancer!?


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Jul 10, 2018 10:15AM claireinaz wrote:

marijen, my reaction exactly. Whaaatttt?

Although here in Arizona, because we are in terrible drought, we don't water anything much anyway.

And where was this Starbucks article (Lumpie)? Did I miss it somewhere?

9/29/11 ILC, 2 c. stage II grade 1, ER/PR+ HER2-, 6/11 nodes, lumpectomy, DDAC x 4, Taxol x 12, 33 rads, Tamoxifen/arimidex/aromasin, BMX/immed recon 7/3/13 "In the midst of winter, I found in me an invincible summer.” Albert Camus
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Jul 10, 2018 05:05PM aterry wrote:

Marijen, There is a warning on some products that I refer to as the California warning. It's not new but I just recently became aware of it. I was buying car cleaning stuff and one item I looked at (didn't buy) had a big yellow warning "This product was manufactured using one or more chemicals known to the State of California to cause cancer and or birth defects. Wash hands after using." Since then I've been looking to see where else the warning pops up. I bought a new lawn sprinkler at Ace hardware (DoItBest) and didn't see the tiny warning until I got home and was reading the set up instructions. I was mad at myself for buying it. I packed it up and mailed it back to the company with a letter; I didn't want to return it to the store to be purchased by some other person. I'm sure the manufacturer will say that the risk is minimal, but....... Now I use a 30-year-old sprinkler that is made from cast iron.

Mostly I'm bummed because it's clear that many, many things that are in our daily orbit are questionable. I'm sure it's not possible to avoid them all and even making informed choices is confusing.

Here's a piece from the American Cancer Society about the warning: https://bit.ly/2ldsDg9


Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/22/2017 Chemotherapy AC + T (Taxol)
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Jul 10, 2018 06:21PM marijen wrote:

Aterry, thanks for the clarification. I wonder if the sprinkler was made in China. I think it’s great we are getting warnings. Especially if on kitchen utensils and toys. I don’t live in CA. If they keep up these warnings maybe manufacturers will get the message. I agree we are exposed to too much toxins in our environment. And now the animals are going extinct because of the way we are degrading the planet. Smog is my pet peeve. I just want clean air and clean water to start. Not adulterated water. Not filthy air. We are all entitled to that at the least.


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Jul 11, 2018 09:39AM claireinaz wrote:

Ah, I get it now. Arizona has no such warning, but I do know about the hazards of paper receipts from stores (grocery etc) and wash my hands to remove the chems that can cause cancer from those receipts. Whole Foods, I know, uses paper that is safe, but others don't.

Claire

9/29/11 ILC, 2 c. stage II grade 1, ER/PR+ HER2-, 6/11 nodes, lumpectomy, DDAC x 4, Taxol x 12, 33 rads, Tamoxifen/arimidex/aromasin, BMX/immed recon 7/3/13 "In the midst of winter, I found in me an invincible summer.” Albert Camus
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Jul 11, 2018 08:27PM aterry wrote:

Marijen & Claireinaz, the warning exists on products all over the country. I live in NYC. I call it the California warning because it relates to legislation passed in that state and because the warning specifically says, "...known to the state of California to cause cancer and/or birth defects...." The guy at the hardware store said to me, "You don't have to worry about it since this isn't California." I said, "Do you think cancer knows what state you live in?" A neighbor found the warning on a portfolio that she bought for her art work. I think it's widespread.

And, yes, the products I saw were made in China but I don't know whether manufacturers in the US have eliminated those chemicals from their supply chain.

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/22/2017 Chemotherapy AC + T (Taxol)
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Jul 11, 2018 09:46PM marijen wrote:

aterry, great answer. What did the hardware guy say to that

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Jul 11, 2018 11:45PM Chemokaze wrote:

Oncolytics: Significant Pipeline Value In The Fastest Growing Area Of Oncology

http://flip.it/IeTS-A


10/2018: NEAD; 7/2018: Onward to Verzenio, Zometa, Faslodex, & CyberKnife to single met to L4 spine. Dx 9/1996, IDC, Left, Stage IB, Grade 3, 0/21 nodes, ER+/PR+ Dx 5/2016, IDC, Right, Stage IIIC, Grade 2, 14/21 nodes, ER+/PR+, HER2- Dx 6/2018, Stage IV, metastasized to bone
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Jul 12, 2018 12:11AM marijen wrote:

Who are 'You People' Anyway? – National Pain Report


http://nationalpainreport.com/who-are-you-people-a...


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Jul 12, 2018 01:49PM marijen wrote:

APPROVED FOR TREATMENT AFTER SURGERY FOR 1 FULL YEAR (UP TO
18 CYCLES)

PERJETA® (pertuzumab) is approved in combination with
Herceptin® (trastuzumab) and chemotherapy for patients with
HER2+ early breast cancer that has a high likelihood of coming back.

https://www.perjeta.com/patient.html

Is this old news? It came in my mail today.

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Jul 12, 2018 01:55PM illimae wrote:

marijen, I think the new part is the additional of Perjeta in early stage treatment. As stage IV HER2+, this combo is standard protocol.

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Targeted Therapy 1/1/2017 Perjeta (pertuzumab) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, Stage IV, metastasized to brain Radiation Therapy 10/19/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 12, 2018 02:35PM MinusTwo wrote:

I agree. I know some women who had H&P along with neo-adjuvant chemo but still had to fight to get their insurance to pay for Perjeta the rest of the year after surgery.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Jul 12, 2018 03:10PM marijen wrote:

Oh good, then I'm glad I posted it. Thanks Illimae and MinusTwo. It says 18% more chance of recurrence for HER+ :(

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Jul 12, 2018 04:42PM illimae wrote:

yeah, 18% is not good. HER2 also likes the brain as I and many have discovered. Oh well, we do what we can.

Thanks for posting all, I read this often but don’t add much.

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Targeted Therapy 1/1/2017 Perjeta (pertuzumab) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, Stage IV, metastasized to brain Radiation Therapy 10/19/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 12, 2018 10:56PM aterry wrote:

Chemokaze, thanks for posting the Siddhartha Mukherjee article. Many times when people learn that I've just been treated for cancer they tell me about anti-cancer diets they've heard about. They are always very intense about these diets and are frustrated if I don't immediately embrace the diet. During my treatment I relied on the nutritionist at the Dubin Breast Center when I wasn't sure how to plan. I think it's great that there will be actual data about a specific approach.

Dx 10/13/2016, IDC, Left, 1cm, Grade 3, ER-/PR-, HER2- Surgery 4/18/2017 Radiation Therapy 5/22/2017 Chemotherapy AC + T (Taxol)
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Jul 13, 2018 10:39AM - edited Jul 13, 2018 10:40AM by mike3121

Something I came across:

https://medicalxpress.com/news/2018-07-scientists-sharpen-edges-cancer-chemotherapy.html

My wife is now on Halaven as her Xeloda failed her. She's tolerating it okay. Her ER/PR+ turned triple negative about 1 1/2 years ago and was put on Xeloda.


Dx 11/12/2012, IDC, Right, 4cm, Stage IV, metastasized to bone, Grade 1, 9/19 nodes, ER+/PR+, HER2- Dx 11/9/2014, Right, Stage IV, Grade 1, ER-/PR-, HER2- Dx 11/15/2016, IDC, Stage IV, metastasized to bone, Grade 1, ER-/PR-, HER2- Surgery Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Right Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Chemotherapy Other Hormonal Therapy Aromasin (exemestane), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 13, 2018 11:31AM Pi-Xi wrote:

Comparison of Treatment Outcomes with Breast-conserving Surgery plus Radiotherapy versus Mastectomy in Patients with Stage I Breast cancer: A Propensity Score-matched Analysis

Not that I had a choice in my surgery, but this wasn't a great abstract for me to see first thing in the morning. Good news for others though.


Oncotype 12 Dx 4/7/2016, DCIS, Left, 2cm, Stage 0, Grade 1, ER+/PR+ Surgery 7/11/2016 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Dx 8/3/2016, DCIS/IDC/IDC: Papillary, Left, 1cm, Grade 2, ER+/PR+, HER2- Hormonal Therapy 8/31/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 14, 2018 12:15AM marijen wrote:

CDC Opioid Restrictions Reading List | EDS and Chronic Pain News & Info - long list of links here


https://edsinfo.wordpress.com/pain/cdc-opioid-restrictions-reading-list/



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Jul 14, 2018 04:36PM marijen wrote:

Get Ready for the Future!

Trackable Pill Technology and Smart Bottles

6 Replies


https://edsinfo.wordpress.com/2018/07/11/trackable...


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Jul 14, 2018 05:38PM Chemokaze wrote:

Fighting Cancer With Cancer: Scientists Use CRISPR To Tweak Tumor Cells And Make Them Attack 'Their Own Kind'

http://flip.it/hq2KKN

(This article includes METASTATIC BREAST CANCER

10/2018: NEAD; 7/2018: Onward to Verzenio, Zometa, Faslodex, & CyberKnife to single met to L4 spine. Dx 9/1996, IDC, Left, Stage IB, Grade 3, 0/21 nodes, ER+/PR+ Dx 5/2016, IDC, Right, Stage IIIC, Grade 2, 14/21 nodes, ER+/PR+, HER2- Dx 6/2018, Stage IV, metastasized to bone
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Jul 14, 2018 05:43PM marijen wrote:

That’s funny! I hope it works

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Jul 17, 2018 12:37AM Lumpie wrote:

Potential DNA damage from CRISPR has been 'seriously underestimated,' study finds

https://www.statnews.com/2018/07/16/crispr-potenti...

Research published on Monday (16 July 2018) suggests that... CRISPR-Cas9 can cause significantly greater genetic havoc than experts thought... perhaps enough to threaten the health of patients who would one day receive CRISPR-based therapy.... Some CRISPR'd cells might be missing a key anti-cancer mechanism ....

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Jul 17, 2018 12:40AM Lumpie wrote:

Curing Metastatic Breast Cancer

http://ascopubs.org/doi/full/10.1200/JOP.2015.0089...

Metastatic breast cancer is generally considered incurable, and this colors doctor-patient interactions for patients with metastatic disease. Although true for most patients, there appear to be important exceptions, instances where long-term disease-free survival occurs. Although these instances are few in number, they suggest the possibility of cure. How will we move toward cure for a much larger population of patients with metastatic disease? This article outlines a potential research agenda that might move us toward that distant goal.

{article is from 2016 but interesting}

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
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Jul 17, 2018 01:07AM marijen wrote:

A very interesting, honest and sobering article Lumpie, thanks for posting. Just as I suspected.



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Jul 17, 2018 03:41PM MinusTwo wrote:

Wow Lumpie. Yes, thanks for posting. Since I had what was called a 'recurrence' after BMX, and the type 'mutated' from DCIS to IDC - this article makes sense of a lot of loose ends.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Jul 18, 2018 08:57AM Heidihill wrote:

Lumpie, thanks for the link. I am a long-term survivor of mets at almost 11 years out. Just eyeballing those stats I will likely make it to 15, even 20.

"Studies of tumor-infiltrating lymphocytes in the adjuvant setting have suggested that their presence is a powerful predictor of outcome, suggesting that we already rely on the immune system for therapeutic impact even in the absence of immune-based therapies.26"

This has been the only explanation that made sense to me, although I don't really know if my tumor had a lot of TILs. Given the outcome, it probably did.

I had neoadjuvant chemo, surgery, radiation and hormonal treatment.

I put my hopes on this article from 2001 when I started treatment in 2007, Can We Cure Limited Metastatic Breast Cancer? The odds were much lower then.

http://ascopubs.org/doi/full/10.1200/JCO.2002.20.3.620

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/25/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 18, 2018 01:16PM marijen wrote:

Heidihill, that’s great for you! May I ask why you didn’t start Tamoxifen until 2015?



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Jul 18, 2018 01:17PM marijen wrote:

FDA Expands Ribociclib Breast Cancer Approval Under New Pilot Programs

https://onclive.cmail19.com/t/j-l-ntujruk-jrtrfkdyh-y/


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